Topical chemotherapy for experimental murine African CNS-trypanosomiasis: The successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436

Tropical Medicine and International Health

Volumn 1, Issue 5, 1996, Pages 590-598

  Jennings, F W ^a   Atouguia, J M ^a,b   Murray, M ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

CNS trypanosomiasis; Melarsoprol; Nitroimidazoles; Topical chemotherapy

Indexed keywords

3A,4,5,6,7,7A HEXAHYDRO 3 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) 1,2 BENZISOXAZOLE; 4 NITROIMIDAZOLE; FEXINIDAZOLE; MELARSOPROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; MOUSE; NONHUMAN; TOPICAL DRUG ADMINISTRATION; TRYPANOSOMIASIS;

ANIMALIA; MURINAE; STAPHYLOCOCCUS PHAGE 3A;

EID: 0029962696     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3156.1996.tb00084.x     Document Type: Article

References (16)

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2. Andrade SG, Silva RC & Santiago CMG (1989) Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bulletin of the World Health Organization 67, 509-514.
3. Atouguia JM, Jennings FW & Murray M (1995) Topical treatment of experimental murine Trypanosoma brucei infection with topical melarsoprol gels. Transactions of the Royal Society of Tropical Medicine and Hygiene 89, 531-533.
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9. Jennings FW, Urquhart GM, Murray PK & Miller BM (1983) Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 693-698.
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