Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats

Archives of Toxicology

Volumn 86, Issue 2, 2012, Pages 217-230

  Heimfarth, Luana ^a   Loureiro, Samanta Oliveira ^a   Reis, Karina Pires ^a   De Lima, Bárbara Ortiz ^a   Zamboni, Fernanda ^a   Lacerda, Sabrina ^a   Soska, Ângela Kronbauer ^a   Wild, Luisa ^a   Da Rocha, João Batista Teixeira ^b   Pessoa Pureur, Regina ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Calcium; Cytoskeleton; DARPP 32; Diphenyl ditelluride; Protein kinase A; Protein phosphatase 1

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6,7 DINITRO 2,3 QUINOXALINEDIONE; CALCINEURIN; CALCIUM CHANNEL L TYPE; CALCIUM ION; CALYCULIN A; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOSPORIN A; CYTOSKELETON PROTEIN; DANTROLENE; DIPHENYL DITELLURIDE; DIZOCILPINE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; IONOTROPIC RECEPTOR; NEUROFILAMENT PROTEIN; NIFEDIPINE; PHOSPHOPROTEIN DARPP 32; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; RYANODINE RECEPTOR; TACROLIMUS; TELLURIUM DERIVATIVE; THREONINE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HIPPOCAMPUS; IN VITRO STUDY; INTERMEDIATE FILAMENT; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALIA; RATTUS;

EID: 84984567283     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0746-6     Document Type: Article

References (86)

1. E Arbustini M Pasotti A Pilotto C Pellegrini M Grasso S Previtali A Repetto O Bellini G Azan M Scaffino C Campana G Piccolo M Vigano L Tavazzi 2006 Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects Eur J Heart Fail 8 477 483 16376610 1:CAS:528:DC%2BD28XotlCjtrc%3D (Pubitemid 44226451)
2. DS Avila D Colle P Gubert AS Palma G Puntel F Manarin S Noremberg PC Nascimento M Aschner JB Rocha FA Soares 2010 A possible neuroprotective action of a vinylic telluride against Mn-induced neurotoxicity Toxicol Sci 115 194 201 20133376 1:CAS:528:DC%2BC3cXkvVOgu78%3D
3. A Baba E Lee T Tatsuno H Iwata 1982 Cysteine sulfinic acid in the central nervous system: antagonistic effect of taurine on cysteine sulfinic acid-stimulated formation of cyclic AMP in guinea pig hippocampal slices J Neurochem 38 1280 1285 6121010 1:CAS:528:DyaL38XkvVGqt7o%3D (Pubitemid 12091487)
4. NBV Barbosa JBT Rocha G Zeni T Emanuelli MC Beque AL Braga 1998 Effect of organic forms of selenium on delta-aminolevulinate dehydratase from liver, kidney and brain of adult rats Toxicol Appl Pharmacol 149 243 253 9571994 1:CAS:528:DyaK1cXis1OnsLs%3D (Pubitemid 28202371)
5. J Bibb GL Snyder A Nishi Z Yan L Meijer AA Fienberg L-H Tsai YT Kwon J-A Girault AJ Czernik RL Huganir HC Hemmings AC Nairn P Greengard 1999 Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons Nature 402 669 671 10604473 1:CAS:528:DC%2BD3cXjs1yj (Pubitemid 129516337)
6. VC Borges JBT Rocha CW Nogueira 2005 Effect of diphenyl diselenide, diphenyl ditelluride and ebselen on cerebral Na+, K+ ATPase activity in rats Toxicology 215 191 197 16095793 1:CAS:528:DC%2BD2MXhtFWmsrfP (Pubitemid 41446321)
7. VB Brito JB Rocha V Folmer F Erthal 2009 Diphenyl diselenide and diphenyl ditelluride increase the latency for 4-aminopyridine-induced chemical seizure and prevent death in mice Acta Biochim Pol 56 125 134 19238257 1:CAS:528:DC%2BD1MXmt1ektrc%3D
8. PTW Cohen 2002 Protein phosphatase 1-targeted in many directions J Cell Sci 115 241 256 11839776 1:CAS:528:DC%2BD38Xht1CmsrY%3D (Pubitemid 34145174)
9. DM Cooper N Mons K Fagan 1994 Ca21-sensitive adenylyl cyclases Cell Signal 6 823 840 7718403 1:CAS:528:DyaK2MXkt1Cltro%3D
10. DM Cooper JW Karpen KA Fagan NE Mons 1998 Ca(21)-sensitive adenylyl cyclases Adv Second Messenger Phosphoprot Res 32 23 51 1:CAS:528: DyaK1cXhvF2jsA%3D%3D
11. LOR Cunha ME Urano JR Chagas PC Almeida C Bincoletto ILS Tersariol JV Comasseto 2005 Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium (IV) compounds as inhibitors of human Cathepsin B Bioorg Med Chem Lett 15 755 760 15664852 1:CAS:528:DC%2BD2MXnsVKqug%3D%3D (Pubitemid 40143161)
12. C D'Addario M Di Benedetto S Candeletti P Romualdi 2007 The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain Brain Res Bull 73 34 39 17499634 (Pubitemid 46710243)
13. LM de Almeida C Funchal PL Pelaez FD Pessutto SO Loureiro L Vivian M Wajner R Pessoa-Pureur 2003 Effect of propionic and methylmalonic acids on the in vitro phosphorylation of intermediate filaments from cerebral cortex of rats during development Metab Brain Dis 18 207 219 14567471 (Pubitemid 37187859)
14. DS de Avila MC Beque V Folmer AL Braga G Zeni CW Nogueira FA Soares JB Rocha 2006 Diethyl 2-phenyl-2 tellurophenyl vinylphosphonate: an organotellurium compound with low toxicity Toxicology 224 100 107 16723180
15. A de Mattos-Dutra M Sampaio de Freitas N Schröder CS Fogaça Lisboa R Pessoa-Pureur M Wajner 1997 In vitro phosphorylation of cytoskeletal proteins in the rat cerebral cortex is decreased by propionic acid Exp Neurol 147 238 247 9344549 (Pubitemid 27497286)
16. N Defer M Best-Belpomme J Hanoune 2000 Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase Am J Physiol Renal Physiol 279 F400 F416 10966920 1:CAS:528:DC%2BD3cXmvFSjs7g%3D
17. M Farina NB Barbosa CW Nogueira V Folmer G Zeni LH Andrade AL Braga JBT Rocha 2002 Reaction of diphenyl diselenide with hydrogen peroxide and inhibition of delta-aminolevulinate dehydratase from rat liver and cucumber leaves Braz J Med Biol Res 35 623 631 12045826 1:CAS:528:DC%2BD38XlsF2msrw%3D (Pubitemid 34716346)
18. J Feng Z Yan A Ferreira K Tomizawa JA Liauw M Zhuo PB Allen CC Ouimet P Greengard 2000 Spinophilin regulates the formation and function of dendritic spines Proc Natl Acad Sci USA 97 9287 9292 10922077 1:CAS:528: DC%2BD3cXls12ktr8%3D (Pubitemid 30626711)
19. E Fernandez R Schiappa JA Girault N Le Novère 2006 DARPP-32 is a robust integrator of dopamine and glutamate signals PLoS Comput Biol 2 e176 17194217
20. H Fiumelli IM Riederer JL Martin BM Riederer 2008 Phosphorylation of neurofilament subunit NF-M is regulated by activation of NMDA receptors and modulates cytoskeleton stability and neuronal shape Cell Motil Cytoskel 65 495 504 1:CAS:528:DC%2BD1cXnvVOqsbs%3D (Pubitemid 351794105)
21. E Fuchs DW Cleveland 1998 A structural scaffolding of intermediate filaments in health and disease Science 279 514 519 9438837 1:CAS:528: DyaK1cXotVKruw%3D%3D (Pubitemid 28067272)
22. C Funchal P de Lima Pelaez SO Loureiro L Vivian F Dall Bello Pessutto LM de Almeida S Tchernin Wofchuk M Wajner R Pessoa Pureur 2002 α- Ketoisocaproic acid regulates phosphorylation of intermediate filaments in postnatal rat cortical slices through ionotropic glutamatergic receptors Brain Res Dev Brain Res 139 267 276 12480141 1:CAS:528:DC%2BD38XptlCru7w%3D (Pubitemid 36001973)
23. C Funchal LM de Almeida S Oliveira Loureiro L Vivian P de Lima Pelaez F Dall Bello Pessutto AM Rosa M Wajner R Pessoa-Pureur 2003 In vitro phosphorylation of cytoskeletal proteins from cerebral cortex of rats Brain Res Prot 11 111 118 1:CAS:528:DC%2BD3sXjsVequrg%3D (Pubitemid 36555951)
24. C Funchal A Zamoner AQ dos Santos MB Moretto JB Rocha M Wajner R Pessoa-Pureur 2005 Evidence that intracellular Ca2+ mediates the effect of alpha-ketoisocaproic acid on the phosphorylating system of cytoskeletal proteins from cerebral cortex of immature rats J Neurol Sci 238 75 82 16111708 1:CAS:528:DC%2BD2MXhtFKmsL%2FL (Pubitemid 41568334)
25. GI Giles FH Fry KM Tasker AL Holme C Peers KN Green LO Klotz H Sies C Jacob 2003 Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential Org Biomol Chem 1 4317 4322 14685335 1:CAS:528: DC%2BD3sXptVWrsLw%3D
26. JP Gou T Gotow PA Janmey JF Leterrier 1998 Regulation of neurofilament interactions in vitro by natural and synthetic polypeptides sharing Lys-Ser-Pro sequences with the heavy neurofilament subunit NF-H: neurofilament crossbridging by antiparallel sidearm overlapping Med Biol Eng Comput 36 371 387 9747580 1:STN:280:DyaK1cvhvFOitQ%3D%3D
27. P Grant HC Pant 2000 Neurofilament protein synthesis and phosphorylation J Neurocytol 29 843 872 11466475 1:CAS:528:DC%2BD3MXntVKgsrw%3D (Pubitemid 32781483)
28. P Grant P Sharma HC Pant 2001 Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism Eur J Biochem 268 1534 1546 11248670 1:CAS:528:DC%2BD3MXitlSktbk%3D (Pubitemid 32862685)
29. SL Green JM Westendorf H Jaffe HC Pant LC Cork EA Ostrander F Vignaux JE Ferrell Jr 2005 Allelic variants of the canine heavy neurofilament (NFH) subunit and extensive phosphorylation in dogs with motor neuron disease J Comp Pathol 132 33 50 15629478 1:CAS:528:DC%2BD2MXks1Cr (Pubitemid 40089651)
30. K Håkansson M Lindskog L Pozzi A Usiello G Fisone 2004 DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia Parkinsonism Relat Disord 10 281 286 15196506 (Pubitemid 38757808)
31. W Hassan M Ibrahim CW Nogueira AL Braga AM Deobald IU Mohammadzai JB Rocha 2009 Influence of pH on the reactivity of diphenyl ditelluride with thiols and anti-oxidant potential in rat brain Chem Biol Interact 180 47 53 19159620 1:CAS:528:DC%2BD1MXltlelsL4%3D
32. L Heimfarth S Oliveira Loureiro A Zamoner P de Lima Pelaez CW Nogueira JBT Rocha R Pessoa-Pureur 2008 Effects of in vivo treatment with diphenyl ditelluride on the phosphorylation of cytoskeletal proteins in cerebral cortex and hippocampus of rats Neurotoxicology 29 40 47 17928058 1:CAS:528: DC%2BD1cXlvVKquw%3D%3D
33. BT Helfand L Chang RD Goldman 2004 Intermediate filaments are dynamic and motile elements of cellular architecture J Cell Sci 117 133 141 14676269 1:CAS:528:DC%2BD2cXhtVams7g%3D (Pubitemid 38128894)
34. H Herrmann U Aebi 2004 Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular scaffolds Annu Rev Biochem 73 749 789 15189158 1:CAS:528:DC%2BD2cXmslagsLc%3D (Pubitemid 39050385)
35. H Herrmann M Hesse M Reichenzeller U Aebi 2003 Functional complexity of intermediate filament cytoskeletons: from structure to assembly to gene ablation Int Rev Cytol 223 83 175 12641211 1:CAS:528:DC%2BD3sXjsl2ntr8%3D (Pubitemid 36278512)
36. M Inagaki Y Matsuoka K Tsujimura S Ando T Tokui T Takahashi N Inagaki 1996 Dynamic property of intermediate filaments: regulation by phosphorylation Bioessays 18 481 487 1:CAS:528:DyaK28XkslSntbk%3D (Pubitemid 126599976)
37. J Kanski J Drake M Aksenova L Engman DA Butterfield 2001 Antioxidant activity of the organotellurium compound 3-[4-(N, N-dimethylamino) benzenetellurenyl]propanesulfonic acid against oxidative stress in synaptosomal membrane systems and neuronal cultures Brain Res 911 12 21 11489439 1:CAS:528:DC%2BD3MXlslGgtrk%3D (Pubitemid 32728234)
38. BP Laden TD Porter 2001 Inhibition oh human squalene monooxigenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls J Lipid Res 42 235 240 11181753 1:CAS:528:DC%2BD3MXhs1KrtL4%3D (Pubitemid 32206835)
39. UK Laemmli 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 277 680 685
40. RC Lariviere JP Julien 2004 Functions of intermediate filaments in neuronal development and disease J Neurobiol 58 131 148 14598376 1:CAS:528:DC%2BD2cXlvVemuw%3D%3D (Pubitemid 37543344)
41. AJ Larner 1995 How does garlic exert its hypocholesterolaemic action? The tellurium hypothesis Med Hypotheses 44 295 297 7666832 1:STN:280: DyaK2Mzps1aqsw%3D%3D
42. VM Lee MJ Carden WW Schlaepfer JQ Trojanowski 1987 Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats J Neurosci 7 3474 3488 3119789 1:CAS:528:DyaL1cXjvVCn (Pubitemid 18000675)
43. R Liu XW Zhou H Tanila C Bjorkdahl JZ Wang ZZ Guan Y Cao JA Gustafsson B Winblad JJ Pei 2008 Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology J Cell Mol Med 12 241 257 18208556 1:CAS:528:DC%2BD1cXltlSqsrc%3D (Pubitemid 351430466)
44. SO Loureiro L Heimfarth P de Lima Pelaez C Simioni Vanzin L Viana ATS Wyse R Pessoa-Pureur 2008 Homocysteine activates calcium-mediated cell signaling mechanisms targeting the cytoskeleton in rat hippocampus Int J Dev Neurosci 26 447 455 18406095 1:CAS:528:DC%2BD1cXlslOktbo%3D
45. SO Loureiro L Heimfarth BA Lacerda LF Vidal A Soska NG dos Santos AT de Souza Wyse R Pessoa-Pureur 2010 Homocysteine induces hypophosphorylation of intermediate filaments and reorganization of actin cytoskeleton in C6 glioma cells Cell Mol Neurobiol 30 557 568 19937110 1:CAS:528:DC%2BC3cXmsVSlt7o%3D
46. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275 14907713 1:CAS:528: DyaG38XhsVyrsw%3D%3D
47. SO Marx S Reiken Y Hisamatsu T Jayaraman D Burkhoff N Rosemblit AR Marks 2000 PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts Cell 101 365 376 10830164 1:CAS:528:DC%2BD3cXjsFekurY%3D
48. N Mons DM Cooper 1994 Adenylyl cyclase mRNA expression does not reflect the predominant Ca21/calmodulin-stimulated activity in the hypothalamus J Neuroendocrinol 6 665 671 7894469 1:CAS:528:DyaK2MXivVGmt74%3D
49. MB Moretto C Funchal G Zeni JBT Rocha R Pessoa-Pureur 2005 Organoselenium compounds prevent hyperphosphorylation of cytoskeletal proteins induced by the neurotoxic agent diphenyl ditelluride in cerebral córtex of young rats Toxicology 210 213 222 15840435 1:CAS:528:DC%2BD2MXjsVGrsL0%3D (Pubitemid 40517165)
50. MB Moretto AP Thomazi G Godinho TM Roessler CW Nogueira DO Souza S Wofchuk JB Rocha 2007 Ebselen and diorganylchalcogenides decrease in vitro glutamate uptake by rat brain slices: prevention by DTT and GSH Toxicol In Vitro 21 639 645 17321101 1:CAS:528:DC%2BD2sXkt1akt7g%3D (Pubitemid 46550749)
51. MB Moretto B Boff J Franco T Posser TM Roessler DO Souza CW Nogueira S Wofchuk JB Rocha 2007 (45)Ca(2+) influx in rat brain: effect of diorganylchalcogenides compounds Toxicol Sci 99 566 571 17656489 1:CAS:528:DC%2BD2sXhtFKru73M (Pubitemid 351753070)
52. J Motil WK Chan M Dubey P Chaudhury A Pimenta TM Chylinski DT Ortiz TB Shea 2006 Dynein mediates retrograde neurofilament transport within axonal neurites and anterograde delivery of NFs from perikarya into axons: regulation by multiple phosphorylation events Cell Motil Cytoskel 63 266 286 1:CAS:528:DC%2BD28XltVGrt74%3D
53. A Nishi JA Bibb GL Snyder H Higashi AC Nairn P Greengard 2000 Amplification of dopaminergic signaling by a positive feedback loop Proc Natl Acad Sci USA 97 12840 12845 11050161 1:CAS:528:DC%2BD3cXotFyksrk%3D
54. RA Nixon 1993 The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathology Brain Pathol 3 29 38 7505700 1:CAS:528:DyaK3sXks12isr4%3D (Pubitemid 23046373)
55. RA Nixon RK Sihag 1991 Neurofilament phosphorylation: a new look at regulation and function Trends Neurosci 14 501 506 1726767 1:CAS:528: DyaK38XktVKh
56. CW Nogueira LN Rotta ML Perry DO Souza JB da Rocha 2001 Diphenyl diselenide and diphenyl ditelluride affect the rat glutamatergic system in vitro and in vivo Brain Res 906 157 163 11430873 1:CAS:528:DC%2BD3MXks1OntLo%3D (Pubitemid 32595550)
57. CW Nogueira VC Borges G Zeni JBT Rocha 2003 Organochalcogens effects on o-aminolevilinate dehydratase activity from human erythrocytic cells in vitro Toxicology 191 169 178 12965120 1:CAS:528:DC%2BD3sXntVKjs7w%3D (Pubitemid 37329462)
58. CW Nogueira G Zeni JBT Rocha 2004 Organoselenium and organotellurium compounds: toxicology and pharmacology Chem Rev 104 6255 6285 15584701 1:CAS:528:DC%2BD2cXpt1SktLw%3D (Pubitemid 40025738)
59. MB Omary NO Ku GZ Tao DM Toivola J Liao 2006 Heads and tails of intermediate filament phosphorylation: multiple sites and functional insights Trends Biochem Sci 31 383 394 16782342 1:CAS:528:DC%2BD28XntFWrsLw%3D (Pubitemid 44038919)
60. JJ Pei I Grundke-Iqbal K Iqbal N Bogdanovic B Winblad RF Cowburn 1997 Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex J Neural Transm 104 1329 1338 9503279 1:STN:280:DyaK1c7msVSisg%3D%3D (Pubitemid 28031827)
61. R Pessoa-Pureur M Wajner 2007 Cytoskeleton as a potential target in the neuropathology of maple syrup urine disease: insight from animal studies J Inher Metab Dis 30 664 672 17574538 1:STN:280:DC%2BD2sngtFCgsw%3D%3D (Pubitemid 47559877)
62. Petragnani N (1994) Preparation of the principal classes of organic tellurium compounds. In: Katritzky AR, Meth-Cohn O, Rees CW (eds) Tellurium in organic synthesis. Academic Press, London, pp 9-88
63. P Pierozan A Zamoner  Soska R Silvestrin SO Loureiro L Heimfarth T Souza M Wajner R Pessoa-Pureur 2010 Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats Exp Neurol 224 188 196 20303347 1:CAS:528:DC%2BC3cXnsVaru74%3D
64. D Rice S Barone Jr 2000 Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models Environ Health Perspect 108 511 533 10852851 (Pubitemid 30466179)
65. B Rinker BF Fink NG Barry JA Fife ME Milan 2010 The effect of calcium channel blockers on smoking-induced skin flap necrosis Plast Reconstr Surg 125 866 871 20195113 1:CAS:528:DC%2BC3cXisFelsL8%3D
66. T Saito H Shima Y Osawa M Nagao BA Hemmings T Kishimoto S Hisanaga 1995 Neurofilament-associated protein phosphatase 2A: its possible role in preserving neurofilaments in filamentous states Biochemistry 34 7376 7384 7779779 1:CAS:528:DyaK2MXlslyqtbg%3D
67. HA Schroeder J Buckman JJ Balassa 1967 Abnormal trace elements in man: tellurium J Chronic Dis 20 147 161 6021520 1:CAS:528:DyaF2sXktF2hs7Y%3D
68. T Shimi V Butin-Israeli SA Adam RD Goldman 2010 Nuclear lamins in cell regulation and disease Cold Spring Harb Symp Quant Biol 75 525 531 21467145 1:STN:280:DC%2BC3Mrmtlajtw%3D%3D
69. RK Sihag M Inagaki T Yamaguchi TB Shea HC Pant 2007 Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments Exp Cell Res 313 2098 2109 17498690 1:CAS:528: DC%2BD2sXmtFOit78%3D (Pubitemid 46842988)
70. Souza RP, Rosa DV, Souza BR, Romano-Silva MA (2006) DARPP-32. AFCS Signal. Gateway. doi: 10.1038/mp.a000752.01
71. AC Souza EC Stangherlin AP Ardais CW Nogueira 2010 Diphenyl diselenide and diphenyl ditelluride: neurotoxic effect in brain of young rats, in vitro Mol Cell Biochem 340 179 185 20179992 1:CAS:528:DC%2BC3cXntlGjt78%3D
72. EC Stangherlin AM Favero G Zeni JBT Rocha CW Nogueira 2005 Teratogenic vulnerability of Wistar rats to diphenyl ditelluride Toxicology 207 231 239 15596254 1:CAS:528:DC%2BD2cXhtVKksrrI (Pubitemid 39642839)
73. S Strack MA Barban BE Wadzinski RJ Colbran 1997 Differential inactivation of postsynaptic density-associated and soluble Ca2+/calmodulin-dependent protein kinase II by protein phosphatases 1 and 2A J Neurochem 68 2119 2128 9109540 1:CAS:528:DyaK2sXivVShs7o%3D (Pubitemid 27176150)
74. S Strack RS Westphal RJ Colbran FF Ebner BE Wadzinski 1997 Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments Brain Res Mol Brain Res 49 15 28 9387859 1:CAS:528: DyaK2sXlsleqt7s%3D (Pubitemid 27453110)
75. P Svenningsson A Nishi G Fisone J-A Girault AC Nairn P Greengard 2004 DARPP-32: an integrator of neurotransmission Annu Rev Pharmacol Toxicol 44 269 296 14744247 1:CAS:528:DC%2BD2cXhvVCktLw%3D (Pubitemid 38263842)
76. CI Tasca LF Cardoso LH Martini G Ramírez DO Souza 1998 Guanine nucleotides inhibit cAMP accumulation induced by metabotropic glutamate receptors activation Neurochem Res 23 183 188 9475513 1:CAS:528: DyaK1cXosVyrtQ%3D%3D (Pubitemid 28130623)
77. A Taylor 1996 Biochemistry of tellurium Biol Trace Elem Res 55 231 239 9096851 1:CAS:528:DyaK2sXisVKisLg%3D (Pubitemid 27152807)
78. KC Tovey KG Oldham JA Whelan 1974 A simple direct assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique Clin Chim Acta 56 221 234 4371263 1:CAS:528: DyaE2MXivVSrtA%3D%3D
79. D Viggiano LA Ruocco AG Sadile 2003 Dopamine phenotype and behaviour in animal models: in relation to attention deficit hyperactivity disorder Neurosci Biobehav Rev 27 623 637 14624807 1:CAS:528:DC%2BD3sXptVemu7k%3D (Pubitemid 37414911)
80. BB Walbran E Robins 1978 Effects of central nervous system accumulation of tellurium on behavior in rats Pharmacol Biochem Behav 9 297 300 714978 1:CAS:528:DyaE1MXhslWguw%3D%3D (Pubitemid 9011693)
81. DF Watson FN Nachtman RW Kuncl JW Griffin 1994 Altered neurofilament phosphorylation and beta tubulin isotypes in Charcot-Marie-Tooth disease type 1 Neurology 44 2383 2387 7991130 1:STN:280:DyaK2M%2FotlWhtw%3D%3D (Pubitemid 24382742)
82. E Widy-Tyszkiewicz A Piechal B Gajkowska M Smialek 2002 Tellurium-induced cognitive deficits in rats are related to neuropathological changes in the central nervous system Toxicol Lett 131 203 214 11992740 1:CAS:528: DC%2BD38Xjt1Wis7k%3D (Pubitemid 34454877)
83. JT Yabe C Jung W Chan TB Shea 2000 Phospho-dependent association of neurofilament proteins with kinesin in situ Cell Motil Cytoskel 45 249 262 1:CAS:528:DC%2BD3cXivVSqsbY%3D (Pubitemid 30196641)
84. MC Yarema SC Curry 2005 Acute tellurium toxicity from ingestion of metal-oxidizing solutions Pediatrics 116 e319 e321 15995006
85. Y Yoshimura Y Sogawa T Yamauchi 1999 Protein phosphatase 1 is involved in the dissociation of Ca2+/calmodulin-dependent protein kinase II from postsynaptic densities FEBS Lett 446 239 242 10100849 1:CAS:528: DyaK1MXhvVCmtLs%3D (Pubitemid 29132734)
86. A Zamoner L Heimfarth S Oliveira Loureiro C Royer FR Mena Barreto Silva R Pessoa-Pureur 2008 Nongenomic actions of thyroxine modulate intermediate filament phosphorylation in cerebral cortex of rats Neuroscience 156 640 652 18760334 1:CAS:528:DC%2BD1cXht1egu7%2FE