Disrupted cytoskeletal homeostasis, astrogliosis and apoptotic cell death in the cerebellum of preweaning rats injected with diphenyl ditelluride

NeuroToxicology

Volumn 34, Issue 1, 2013, Pages 175-188

  Heimfarth, Luana ^a   Loureiro, Samanta Oliveira ^a   Dutra, Márcio Ferreira ^a   Petenuzzo, Letícia ^a   de Lima, Bárbara Ortiz ^a   Fernandes, Carolina Gonçalves ^a   da Rocha, João Batista Teixeira ^b   Pessoa Pureur, Regina ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Apoptosis; Astrogliosis; Cell signaling; Cerebellum; Cytoskeleton; Diphenyl ditelluride

Indexed keywords

CASPASE 3; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIPHENYL DITELLURIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; INTERMEDIATE FILAMENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROFILAMENT H PROTEIN; NEUROFILAMENT L PROTEIN; NEUROFILAMENT M PROTEIN; NEURON SPECIFIC NUCLEAR PROTEIN; PROPIDIUM IODIDE; PROTEIN KINASE B; TOXIC SUBSTANCE; UNCLASSIFIED DRUG; VIMENTIN;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; ASTROCYTOSIS; CELL POPULATION; CEREBELLUM; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; FEMALE; FLOW CYTOMETRY; HOMEOSTASIS; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MALE; NERVE CELL; NEUROTOXICITY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN HYPERPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; WESTERN BLOTTING;

EID: 84984562141     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.10.015     Document Type: Article

References (46)

1. Andrade C.M., Roesch G.C., Wink M.R., Guimaraes E.L., Souza L.F., Jardim F.R., et al. Activity and expression of ecto-5'-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line. Life Sci 2008, 82:21-29.
2. Biran V., Verney C., Ferriero D.M. Perinatal cerebellar injury in human and animal models. Neurol Res Int 2012, 10.1155/2012/858929.
3. Butterworth R.F. Metal toxicity, liver disease and neurodegeneration. Neurotox Res 2010, 18:100-105.
4. Dobbing J., Hopewell J.W., Lynch A., Sands J. Vulnerability of developing brain: I. Some lasting effects of X irradiation. Exp Neurol 1970, 28:442-449.
5. Dobbing J., Sands J. Quantitative growth and development of human brain. Arch Dis Childhood 1973, 48:757-767.
6. Dobbing J. The later growth of the brain and its vulnerability. Pediatrics 1974, 53:2-6.
7. Frizzo M.E.S., Lara D.R., Prokopiuk A.S., Vargas C.R., Salbego C.G., Wajner M., et al. Guanosine enhances glutamate uptake in brain cortical slices at normal and excitotoxic conditions. Cell Mol Neurobiol 2002, 22:353-363.
8. Funchal C., de Almeida L.M., Oliveira Loureiro S., Vivian L., de Lima Pelaez P., Dall Bello Pessutto F., et al. In vitro phosphorylation of cytoskeletal proteins from cerebral cortex of rats. Brain Res Prot 2003, 11:111-118.
9. Heimfarth L., Loureiro S.O., Reis K.P., de Lima B.O., Zamboni F., Gandolfi T., et al. Cross-talk among intracellular signaling pathways mediates the diphenyl ditelluride actions on the hippocampal cytoskeleton of young rats. Chem Res Toxicol 2011, 24:1754-1764.
10. Heimfarth L., Loureiro S.O., Reis K.P., de Lima B.O., Zamboni F., Lacerda S., et al. Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats. Arch Toxicol 2012, 86:217-230.
11. Heimfarth L., Loureiro S.O., Dutra M.F., Andrade C., Pettenuzzo L., Guma F.T.C.R., et al. In vivo treatment with diphenyl ditelluride induces neurodegeneration in striatum of young rats: implications of MAPK and Akt pathways. Toxicol Appl Pharmacol 2012, 264:143-152.
12. Hisanaga S., Matsuoka Y., Nishizawa K., Saito T., Inagaki M., Hirokawa N. Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase. Mol Biol Cell 1994, 5:161-172.
13. Iriyama T., Kamei Y., Kozuma S., Taketani Y. Bax-inhibiting peptide protects glutamate-induced cerebellar granule cell death by blocking Bax translocation. Neurosci Lett 2009, 451:11-15.
14. Ito M., Natsume A., Takeuchi H., Shimato S., Ohno M., Wakabayashi T., et al. Type I interferon inhibits astrocytic gliosis and promotes functional recovery after spinal cord injury by deactivation of the MEK/ERK pathway. J Neurotrauma 2009, 26:41-53.
15. Jahani-Asl A., Pilon-Larose K., Xu W., MacLaurin J.G., Park D.S., McBride H.M., et al. The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity. J Biol Chem 2011, 286:4772-4782.
16. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
17. Lee S.B., Bagley J.A., Lee H.Y., Jan L.Y., Jan Y.N. Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila. Proc Natl Acad Sci USA 2011, 108:16795-16800.
18. Liu W, Xu Z, Deng Y, Xu B, Yang H, Wei Y, et al. Excitotoxicity and oxidative damages induced by methylmercury in rat cerebral cortex and the protective effects of tea polyphenols. Environ Toxicol 2012; Epub ahead of print.
19. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Method Methods 2001, 25:402-408.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
21. Motil J., Chan W.K., Dubey M., Chaudhury P., Pimenta A., Chylinski T.M., et al. Dynein mediates retrograde neurofilament transport within axons and anterograde delivery of NFs from perikarya into axons: regulation by multiple phosphorylation events. Cell Motil Cytoskeleton 2006, 63:266-286.
22. Muller R., Zschiesche W., Steffen H., Schaller K. Tellurium-intoxication. Klin Wochenschr 1989, 67:1152-1155.
23. Nguyen D., Alavi M.V., Kim K.Y., Kang T., Scott R.T., Noh Y.H., et al. A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics. Cell Death Dis 2011, 2:e240. 10.1038/cddis.2011.117.
24. Paulino A.D., Ubhi K., Rockenstein E., Adame A., Crews L., Letendre S., et al. Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling. J Neurovirol 2011, 17:327-340.
25. Pekny M., Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005, 50:427-434.
26. Perrot R., Eyer J. Neuronal intermediate filaments and neurodegenerative disorders. Brain Res Bull 2009, 80:282-295.
27. Perrot R., Berges R., Bocquet A., Eyer J. Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration. Mol Neurobiol 2008, 38:27-65.
28. Petragnani N. Preparation of the principal classes of organic tellurium compounds. Tellurium in organic synthesis 1994, Academic Press, London, p. 9-88.
29. Pessoa-Pureur R., Wajner M. Cytoskeleton as a potential target in the neuropathology of maple syrup urine disease: insight from animal studies. J Inherit Metab Dis 2007, 30:664-672.
30. Roy S., Hardej D. Tellurium tetrachloride and diphenyl ditelluride cause cytotoxicity in rat hippocampal astrocytes. Food Chem Toxicol 2011, 49:2564-2574.
31. Sheldon A.L., Robinson M.B. The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem Int 2007, 51:333-355.
32. Sihag R.K., Inagaki M., Yamaguchi T., Shea T.B., Pant H.C. Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments. Exp Cell Res 2007, 313:2098-2109.
33. Sofroniew M.V., Vinters H.V. Astrocytes: biology and pathology. Acta Neuropathol 2010, 119:7-35.
34. Souza A.C., Stangherlin E.C., Ardais A.P., Nogueira C.W. Diphenyl diselenide and diphenyl ditelluride: neurotoxic effect in brain of young rats, in vitro. Mol Cell Biochem 2010, 340:179-185.
35. Stangherlin E.C., Rocha J.B., Nogueira C.W. Diphenyl ditelluride impairs short-term memory and alters neurochemical parameters in young rats. Pharmacol Biochem Behav 2009, 91:430-435.
36. Taylor A. Biochemistry of tellurium. Biol Trace Elem Res 1996, 55:231-239.
37. Veeranna Amin N.D., Ahn N.G., Jaffe H., Winters C.A., Grant P., Pant H.C. Mitogen-activated protein kinases (Erk1, 2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. J Neurosci 1998, 18:4008-4021.
38. Villanueva R. The cerebellum and neuropsychiatric disorders. Psychiatry Res 2012, 15(198):527-532.
39. Widy-Tyszkiewicz E., Piechal A., Gajkowska B., Smiałek M. Tellurium-induced cognitive deficits in rats are related to neuropathological changes in the central nervous system. Toxicol Lett 2002, 131:203-214.
40. Yabe J.T., Chan W., Shea T.B. Phospho-dependent association of neurofilament proteins with kinesin in situ. Cell Motil Cytoskeleton 2000, 45:249-265.
41. Yakovlev A.G., Faden A.I. Caspase-dependent apoptotic pathways in CNS injury. Mol Neurobiol 2001, 24:131-144.
42. Yang E.J., Min J.S., Ku H.Y., Choi H.S., Park M.K., Kim M.K., et al. Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. Biochem Biophys Res Commun 2012, 421:658-664.
43. Yarema M.C., Curry S.C. Acute tellurium toxicity from ingestion of metal-oxidizing solutions. Pediatrics 2005, 116:319-321.
44. Yu P., Wang H., Katagiri Y., Geller H.M. An in vitro model of reactive astrogliosis and its effect on neuronal growth. Methods Mol Biol 2012, 814:327-340.
45. Zhang D., Hu X., Qian L., O'Callaghan J.P., Hong J-S. Astrogliosis in CNS pathologies: is there a role for microglia. Mol Neurobiol 2010, 41:232-241.
46. Zhao H., Sapolsky R.M., Steinberg G.K. Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 2006, 34:249-270.