Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling

Journal of NeuroVirology

Volumn 17, Issue 4, 2011, Pages 327-340

  Paulino, Amy D ^a,f   Ubhi, Kiren ^a   Rockenstein, Edward ^a   Adame, Anthony ^a   Crews, Leslie ^b   Letendre, Scott ^c   Ellis, Ronald ^a   Everall, Ian P ^d,g   Grant, Igor ^d,e   Masliah, Eliezer ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^f Neuropore Therapies Inc   (United States)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

ERK; HCV; Neurodegeneration; TLR2

Indexed keywords

CORE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; STAT3 PROTEIN; TOLL LIKE RECEPTOR 2;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITE; ENZYME ACTIVATION; FEMALE; HEPATITIS C VIRUS; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; MOLECULAR MECHANICS; MOUSE; NEOCORTEX; NERVE CELL; NERVE DEGENERATION; NERVE INJURY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

ADULT; ANIMALS; BLOTTING, WESTERN; COINFECTION; FEMALE; GENE SILENCING; HEPACIVIRUS; HEPATITIS C; HIPPOCAMPUS; HIV; HIV INFECTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; INJECTIONS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MALE; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MIDDLE AGED; NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 2; VIRAL CORE PROTEINS;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 80054732027     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-011-0039-0     Document Type: Article

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