Redox modulation at the peripheral site alters nociceptive transmission in vivo

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 3, 2009, Pages 272-277

  Meotti, Flavia C ^a   Coelho, Igor S ^a   Franco, Jeferson L ^a   Dafre, Alcir L ^a   Rocha, João Bt ^b   Santos, Adair Rs ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Ebselen; Nociception; Redox modulation; Thiol groups

Indexed keywords

5,5' DITHIOBIS(2 NITROBENZOIC ACID); BUTHIONINE SULFOXIMINE; DITHIOTHREITOL; DIZOCILPINE; EBSELEN; GLUTAMIC ACID; GLUTATHIONE; IODOACETIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE; THIOL GROUP;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; COLORIMETRY; CONTROLLED STUDY; FEMALE; FOOT PAD; IN VIVO STUDY; LICKING; MOUSE; NEUROMODULATION; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; OXIDATION REDUCTION REACTION;

EID: 84984541261     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05056.x     Document Type: Article

References (37)

1. Bhave G, Gereau RW. Posttranslational mechanisms of peripheral sensitization. J. Neurobiol. 2004 61 : 88 106.
2. Pathirathna S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain 2006 125 : 53 64.
3. Todorovic SM, Jevtovic-Todorovic V, Meyenburg A et al. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron 2001 31 : 75 85.
4. 2+ channels in vivo: Alteration of nerve injury-induced thermal hyperalgesia. Pain 2004 109 : 328 39.
5. Herin GA, Du S, Aizenman E. The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site. J. Neurochem. 2001 78 : 1307 14.
6. Laughlin TM, Kitto KF, Wilcox GL. Redox manipulation of NMDA receptors in vivo: Alteration of acute pain transmission and dynorphin-induced allodynia. Pain 1999 80 : 37 43.
7. Woodward JJ. The effects of thiol reduction and oxidation on the inhibition of NMDA-stimulated neurotransmitter release by ethanol. Neuropharmacology 1994 33 : 635 40.
8. Gozlan H, Ben-Ari Y. NMDA receptor redox sites: Are they targets for selective neuronal protection? Trends Pharmacol. Sci. 1995 16 : 368 74.
9. Choi YB, Lipton SA. Redox modulation of the NMDA receptor. Cell. Mol. Life Sci. 2000 57 : 1535 41.
10. Wendel A, Fausel M, Safayhi H, Tiegs G, Otter R. A novel biologically active seleno-organic compound: II. Activity of PZ51 in relation to glutathione peroxidase. Biochem. Pharmacol. 1984 33 : 3241 5.
11. Schewe T. Molecular actions of ebselen: An antiinflammatory antioxidant. Gen. Pharmacol. 1995 26 : 1153 69.
12. Jacob C, Maret W, Vallee BL. Control of zinc transfer between thionein, metallothionein, and zinc proteins. Proc. Natl Acad. Sci. USA 1998 95 : 3489 94.
13. Dimmeler S, Brune B, Ullrich V. Ebselen prevents inositol (1,4,5)-trisphosphate binding to its receptor. Biochem. Pharmacol. 1991 42 : 1151 3.
14. Nogueira CW, Borges VC, Zeni G, Rocha JB. Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro. Toxicology 2003 191 : 169 78.
15. Rossato JI, Zeni G, Mello CF, Rubin MA, Rocha JB. Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat. Neurosci. Lett. 2002 318 : 137 40.
16. Porciuncula LO, Schmidt AP, Coitinho AS et al. Intrahippocampal infusion of ebselen impairs retention of an inhibitory avoidance task in rats. Eur. J. Pharmacol. 2002 451 : 165 9.
17. Beirith A, Santos AR, Calixto JB. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain Res. 2002 924 : 219 28.
18. Meotti FC, Luiz AP, Pizzolatti MG, Kassuya CA, Calixto JB, Santos AR. Analysis of the antinociceptive effect of the flavonoid myricitrin: Evidence for a role of the l-arginine-nitric oxide and protein kinase C pathways. J. Pharmacol. Exp. Ther. 2006 316 : 789 96.
19. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983 16 : 109 10.
20. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 1969 27 : 502 22.
21. Franco JL, Trivella DB, Trevisan R et al. Antioxidant status and stress proteins in the gills of the brown mussel Perna perna exposed to zinc. Chem. Biol. Interact. 2006 160 : 232 40.
22. Ellman GL. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959 82 : 70 7.
23. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976 72 : 248 54.
24. Abele R, Lampinen M, Keinanen K, Madden DR. Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4- propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors. J. Biol. Chem. 1998 273 : 25 132 8.
25. Bernard CL, Hirsch JC, Khazipov R, Ben-Ari Y, Gozlan H. Redox modulation of synaptic responses and plasticity in rat CA1 hippocampal neurons. Exp. Brain Res. 1997 113 : 343 52.
26. Sullivan JM, Traynelis SF, Chen HS, Escobar W, Heinemann SF, Lipton SA. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron 1994 13 : 929 36.
27. Cotgreave IA, Morgenstern R, Engman L, Ahokas J. Characterisation and quantitation of a selenol intermediate in the reaction of ebselen with thiols. Chem. Biol. Interact. 1992 84 : 69 76.
28. Jung CH, Washburn MP, Wells WW. Ebselen has dehydroascorbate reductase and thioltransferase-like activities. Biochem. Biophys. Res. Commun. 2002 291 : 550 3.
29. Singh R, Kats L. Catalysis of reduction of disulfide by selenol. Anal. Biochem. 1995 232 : 86 91.
30. Meister A, Griffith OW, Novogrodsky A, Tate SS. New aspects of glutathione metabolism and translocation in mammals. Ciba Found. Symp. 1979 : 135 61.
31. Tang LH, Aizenman E. The modulation of N-methyl-d-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro. J. Physiol. 1993 465 : 303 23.
32. Gadotti VM, Tibola D, Paszcuk AF, Rodrigues AL, Calixto JB, Santos AR. Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice. Brain Res. 2006 1093 : 116 22.
33. Haddad JJ. Pharmaco-redox regulation of cytokine-related pathways: From receptor signaling to pharmacogenomics. Free Radic. Biol. Med. 2002 33 : 907 26.
34. Yao H, Yang SR, Kode A et al. Redox regulation of lung inflammation. Role of NADPH oxidase and NF-kappaB signalling. Biochem. Soc. Trans. 2007 35 : 1151 5.
35. Andrey F, Tsintsadze T, Volkova T, Lozovaya N, Krishtal O. Acid sensing ionic channels: Modulation by redox reagents. Biochim. Biophys. Acta 2005 1745 : 1 6.
36. Amato A, Connolly CN, Moss SJ, Smart TG. Modulation of neuronal and recombinant GABAA receptors by redox reagents. J. Physiol. 1999 517 : 35 50.
37. Ben-Haim D, Landau EM, Silman I. The role of a reactive disulphide bond in the function of the acetylcholine receptor at the frog neuromuscular junction. J. Physiol. 1973 234 : 305 25.