Intrahippocampal infusion of ebselen impairs retention of an inhibitory avoidance task in rats

European Journal of Pharmacology

Volumn 451, Issue 2, 2002, Pages 165-169

  Porciúncula, Lisiane O ^a   Schmidt, André P ^a   Coitinho, Adriana S ^a   Vinadé, Lúcia ^b   Izquierdo, Iván ^a   Rocha, João Batista T ^c   Souza, Diogo O ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Avoidance inhibitory; Ebselen; Learning; Memory

Indexed keywords

EBSELEN;

ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INFUSION; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

EID: 84984589100     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02221-5     Document Type: Article

References (30)

1. Almaguer-Melian W., Cruz-Aguado R., Bergado J.A. Synaptic plasticity is impaired in rats with a low glutathione content. Synapse. 38:2000;369-374.
2. Bernard C.L., Hirsch J.C., Khazipov R., Ben-Ari Y., Gozlan H. Redox modulation of synaptic responses and plasticity in rat CA1 hippocampal neurons. Exp. Brain Res. 113:1997;343-352.
3. Castellano C., Cestari V., Ciamei A. NMDA receptors and learning and memory processes. Curr. Drug Targets. 2:2001;273-283.
4. Dubey A., Forster M.J., Lal H., Sohal R.S. Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch. Biochem. Biophys. 333:1996;189-197.
5. Herin G.A., Du S., Aizenman E. The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site. J. Neurochem. 78:2001;1307-1314.
6. Imai H., Masayasu H., Dewar D., Graham D.I., Macrae I.M. Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke. 32:2001;2149-2154.
7. Izquierdo I., McGaugh J.L. Behavioural pharmacology and its contribution to the molecular basis of memory consolidation. Behav. Pharmacol. 11:2000;517-534.
8. Izquierdo I., da Cunha C., Rosat R., Jerusalinsky D., Ferreira M.B., Medina J.H. Neurotransmitter receptors involved in post-training memory processing by the amygdala, medial septum, and hippocampus of the rat. Behav. Neural Biol. 58:1992;16-26.
9. Izquierdo I., Quillfeldt J.A., Zanatta M.S., Quevedo J., Schaeffer E., Schmitz P.K., Medina J.H. Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats. Eur. J. Neurosci. 9:1997;786-793.
10. Lee J.M., Zipfel G.J., Choi D.W. The changing landscape of ischaemic brain injury mechanisms. Nature. 399:1999;A7-A14.
11. Lipton S.A., Rosenberg P.A. Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330:1994;613-622.
12. Malecki A., Garrido R., Mattson M.P., Henning B., Toborek M. 4-Hydroxynonenal induces oxidative stress and death of cultured spinal cord neurons. J. Neurochem. 74:2000;2278-2287.
13. Morris R.G.M., Davis M. The role of NMDA receptors in learning and memory. Collingridge G.L., Watkins J.C. The NMDA Receptor. 1994;340-375 Oxford Univ. Press, Oxford.
14. Moussaoui S., Obinu M.C., Daniel N., Reibaud M., Blanchard V., Imperato A. The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease. Exp. Neurol. 166:2000;235-245.
15. Müller A., Cadenas E., Graf P., Sies H. A novel biologically active seleno-organic compound I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (ebselen). Biochem. Pharmacol. 33:1984;3235-3239.
16. Namura S., Nagata I., Takami S., Masayasu H., Kikuchi H. Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke. 32:2001;1906-1911.
17. Nogueira C.W., Soares F.A., Bolzan R.C., Jacques-Silva M.C., Souza D.O., Rocha J.B. Investigations into the mechanism of 2,3-dimercaptopropanol neurotoxicity. Neurochem. Res. 25:2000;1553-1558.
18. Nogueira C.W., Rotta L.L., Tavares R.G., Souza D.O., Rocha J.B. BAL modulates glutamate transport in synaptosomes and synaptic vesicles from rat brain. NeuroReport. 12:2001;511-514.
19. Noiri E., Nakao A., Uchida K., Tsukahara H., Ohno M., Fujita T., Brodsky S., Goligorsky M.S. Oxidative and nitrosative stress in acute renal ischemia. Am. J. Physiol. Renal Physiol. 281:2001;F948-F957.
20. Ozawa S., Kamiya H., Tsuzuki K. Glutamate receptors in the mammalian central nervous system. Prog. Neurobiol. 54:1998;581-618.
21. Parnham M., Sies H. Ebselen: prospective therapy for cerebral ischaemia. Expert Opin. Investig. Drugs. 9:2000;607-619.
22. Porciúncula L.O., Rocha J.B.T., Boeck C.R., Vendite D., Souza D.O. Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons. Neurosci. Lett. 299:2001;217-220.
23. Récasens M., Mayat E., Vignes M. The multiple excitatory amino acid receptor subtypes and their putative interactions. Mol. Neuropharmacol. 2:1992;15-31.
24. Roesler R., Vianna M., Sant' Anna M.K., Kuyven C.R., Kruel A.V.S., Quevedo J., Ferreira M.B.C. Intrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: protection from impairment by pretraining or preexposure to the task apparatus. Neurobiol. Learn. Mem. 69:1998;87-91.
25. Rossato J.I., Zeni G., Mello C.F., Rubin M.A., Rocha J.B. Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat. Neurosci. Lett. 318:2002;137-140.
26. Saito I., Asano T., Sano K., Takakura K., Abe H., Yoshimoto T., Kikuchi H., Ohta T., Ishibashi S. Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery. 42:1998;269-278.
27. Schewe C., Schewe T., Wendel A. Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione. Biochem. Pharmacol. 48:1994;65-74.
28. Tang L.H., Aizenman E. Long-lasting modification of the N-methyl-D-aspartate receptor channel by a voltage-dependent sulfhydryl redox process. Mol. Pharmacol. 44:1993;473-478.
29. Tang L.H., Aizenman E. The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro. J. Physiol. 465:1993;303-323.
30. Yamaguchi T., Sano K., Takakura K., Saito I., Shinohara Y., Asano T., Yasuhara H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Stroke. 29:1998;12-17.