High-throughput drug profiling with voltage-and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 311, Issue 1, 2016, Pages H44-H53

  Bedut, Stephane ^a,b   Seminatore Nole, Christine ^a   Lamamy, Veronique ^b   Caignard, Sarah ^b   Boutin, Jean A ^b   Nosjean, Olivier ^b   Stephan, Jean Philippe ^b   Coge, Francis ^b  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

96 well plate; Cardiomyocytes; Cell signaling; Induced pluripotent stem cells; Membrane potentials

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM SENSITIVE FLUORESCENT PROBE; DIMETHYL SULFOXIDE; DOFETILIDE; FLUORESCENT DYE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; INOTROPIC AGENT; IVABRADINE; LIDOCAINE; NIFEDIPINE; UNCLASSIFIED DRUG; VERATRIDINE; VOLTAGE SENSITIVE FLUORESCENT PROBE;

ACTION POTENTIAL; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CARDIAC MUSCLE CELL; CELL DENSITY; CELL SIZE; ELECTRIC ACTIVITY; ELECTRON TRANSPORT; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MEMBRANE POTENTIAL; MICROELECTRODE; MICROPLATE READER; PRIORITY JOURNAL; TOXICITY TESTING; VOLTAGE SENSITIVE DYE IMAGING; WAVEFORM; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; HEART CONTRACTION; LABORATORY AUTOMATION; METABOLISM; SIGNAL PROCESSING; TIME FACTOR;

ACTION POTENTIALS; AUTOMATION, LABORATORY; CALCIUM SIGNALING; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICROSCOPY, FLUORESCENCE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; SIGNAL PROCESSING, COMPUTER-ASSISTED; TIME FACTORS;

EID: 84983800990     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00793.2015     Document Type: Article

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