Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial

Journal of Nutrition in Gerontology and Geriatrics

Volumn 35, Issue 3, 2016, Pages 209-218

  Mozaffari Khosravi, Hassan ^a   Naderi, Zahra ^a   Dehghan, Ali ^a   Nadjarzadeh, Azadeh ^a   Fallah Huseini, Hassan ^b  

^a SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

Author keywords

ginger; inflammation; Osteoarthritis

Indexed keywords

CYTOKINE;

AGED; BLOOD; CONTROLLED STUDY; DIETARY SUPPLEMENT; DOUBLE BLIND PROCEDURE; ELDERLY CARE; FEMALE; GINGER; HUMAN; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; PHYTOTHERAPY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

AGED; CYTOKINES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GINGER; HEALTH SERVICES FOR THE AGED; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; PHYTOTHERAPY; TREATMENT OUTCOME;

EID: 84983755355     PISSN: 21551197     EISSN: 21551200     Source Type: Journal    
DOI: 10.1080/21551197.2016.1206762     Document Type: Article

References (32)

1. K.Heidari BKnee. Osteoarthritis prevalence, risk factors, pathogenesis and features:part I. Caspian Journal Of Internal Medicine. 2011; 2(2):205–12.
2. M.J.Leach, S.Kumar. The clinical effectiveness of Ginger (Zingiber officinale) in adults with osteoarthritis. Int J Evid Based Healthc. 2008; 6(3):311–20.
3. A.M.Valdes, T.D.Spector. The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol. 2010; 22(2):139.
4. A.Leask. Will o’the wisp:CCN4 as a novel molecular target in osteoarthritis. J Cell Commun Signal. 2011; 5(1):51–2.
5. Y.Toda, N.Tsukimura. A six‐month followup of a randomized trial comparing the efficacy of a lateral‐wedge insole with subtalar strapping and an in‐shoe lateral‐wedge insole in patients with varus deformity osteoarthritis of the knee. Arthritis & Rheumatism. 2004; 50(10):3129–36.
6. K.T.Palmer. Occupational activities and osteoarthritis of the knee. Br Med Bull. 2012; 102(1):147–70.
7. D.McWilliams, B.Leeb, S.Muthuri, M.Doherty, W.Zhang. Occupational risk factors for osteoarthritis of the knee:a meta-analysis. Osteoarthritis and Cartilage. 2011; 19(7):829–39.
8. B.Goker, A.M.Doughan, T.J.Schnitzer, J.A.Block. Quantification of progressive joint space narrowing in osteoarthritis of the hip:longitudinal analysis of the contralateral hip after total hip arthroplasty. Arthritis & Rheumatism. 2001; 43(5):988–94.
9. J.Franklin, T.Ingvarsson, M.Englund, S.Lohmander. Research article. Association between occupation and knee and hip replacement due to osteoarthritis:a case-control study. Arthritis Research and Therapy. 2010; 12(3):1–9.
10. A.Haghighi, N.Tavalaei, M.B.Owlia. Effects of ginger on primary knee osteoarthritis. Indian Journal of Rheumatology. 2006; 1(1):3–7.
11. M.Mamdani. The changing landscape for Cox-2 inhibitors:a summary of recent events. Healthcare Quarterly. 2005; 8(2):–25.
12. F.E.Silverstein, G.Faich, J.L.Goldstein, L.S.Simon, T.Pincus, A.Whelton, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis. JAMA. 2000; 284(10):1247–55.
13. J.Dingle. The effects of NSAID on the matrix of human articular cartilages. Zeitschrift für Rheumatologie. 1999; 58(3):125–9.
14. Z.Zakeri, S.Izadi, Z.Bari, F.Soltani, B.Narouie, M.Ghasemi-rad. Evaluating the effects of ginger extract on knee pain, stiffness and difficulty in patients with knee osteoarthritis. Journal of Medical Plants Research. 2011; 5(15):3375–79.
15. J.R.Niebyl. Nausea and vomiting in pregnancy. New England Journal of Medicine. 2010; 363(16):1544–50.
16. S.Ahmed, J.Anuntiyo, C.J.Malemud, T.M.Haqqi. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis:a review. Evidence-Based Complementary and Alternative Medicine. 2005; 2(3):301–8.
17. S.Mahluji, A.Ostadrahimi, M.Mobasseri, V.E.Attari, L.Payahoo. Anti-Inflammatory Effects of Zingiber Officinale in Type 2 Diabetic Patients. Age (yr). 2013; 49(5.18):53.14–7.9.
18. R.Grzanna, L.Lindmark, C.G.Frondoza. Ginger-an herbal medicinal product with broad anti-inflammatory actions. Journal of medicinal food. 2005; 8(2):125–32.
19. S.Atashak, M.Peeri, A.Jafari. Effects of 10 week resistance training and ginger consumption on C-reactive protein and some cardiovascular risk factors in obese men. Physiology and Pharmacology. 2010; 14(3):318–28.
20. W.Willett. Nutritional epidemiology. Oxford University Press, USA; 1998.
21. F.Larkin, H.Metzner, K.Guire. Comparison of three consecutive-day and three random-day records of dietary intake. Journal of the American Dietetic Association. 1991; 91(12):1538.
22. H.W.Jung, C.H.Yoon, K.M.Park, H.S.Han, Y.K.Park. Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway. Food and chemical toxicology:an international journal published for the British Industrial Biological Research Association. 2009; 47(6):1190.
23. M.Khalili, Z.Kiasalari, E.Farhadi, M.Agah. Effects of alcoholic extract of Zingiber officinalis rhizome on acute and chronic inflammation and pain in rats. Koomesh. 2010; 12(2):Pe159–Pe66, En22.
24. C.G.Frondoza, A.Sohrabi, A.Polotsky, P.V.Phan, D.S.Hungerford, L.Lindmark. An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures. In Vitro Cellular & Developmental Biology-Animal. 2004; 40(3):95–101.
25. A.M.M.Fouda, M.Y.Berika. Evaluation of the Effect of Hydroalcoholic Extract of Zingiber officinale Rhizomes in Rat Collagen‐induced Arthritis. Basic & clinical pharmacology & toxicology. 2009; 104(3):262–71.
26. G.Ramadan, M.A.Al-Kahtani, W.M.El-Sayed. Anti-inflammatory and anti-oxidant properties of Curcuma longa (Turmeric) versus Zingiber officinale (Ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation. 2011; 34(4):291–301.
27. J.A.Podlogar, E.J.Verspohl. Antiinflammatory Effects of Ginger and Some of its Components in Human Bronchial Epithelial (BEAS‐2B) Cells. Phytotherapy Research. 2011; 26(3):333–6.
28. H.Ueda, K.Ippoushi, A.Takeuchi. Repeated Oral Administration of a Squeezed Ginger (Zingiber officinale) Extract Augmented the Serum Corticosterone Level and Had Anti-Inflammatory Properties. Bioscience, biotechnology, and biochemistry. 2010; 74(11):2248–52.
29. S.Julie, M.Jurenka. Anti-inflammatory Properties of Curcumin, a Major Constituent. Alternative Medicine Review. 2009; 14(2).
30. S.Dugasani, M.R.Pichika, V.D.Nadarajah, M.K.Balijepalli, S.Tandra, J.N.Korlakunta. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol,[8]-gingerol,[10]-gingerol and [6]-shogaol. Journal of ethnopharmacology. 2010; 127(2):515.
31. L.G.Ameye, W.S.S.Chee. Osteoarthritis and nutrition. From nutraceuticals to functional foods:a systematic review of the scientific evidence. Arthritis Research and Therapy. 2006; 8(4):127.
32. H.G.Hegazy. Ameliorative effects of ginger and α -lipoic acid on oxidative stress and inflammation in senile female rats. African Journal of Pharmacy and Pharmacology. 2011; 5(8):1096–105.