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Volumn 16, Issue 1, 2016, Pages

Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs: A systematic review and meta-analysis

Author keywords

Breast cancer; FOXP3; Prognosis; TIL

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

EID: 84983681647     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-016-2732-0     Document Type: Article
Times cited : (112)

References (46)
  • 2
    • 79959745851 scopus 로고    scopus 로고
    • The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis
    • Gooden MJ, de Bock GH, Leffers N, Daemen T, Nijman HW. The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br J Cancer. 2011;105(1):93-103.
    • (2011) Br J Cancer , vol.105 , Issue.1 , pp. 93-103
    • Gooden, M.J.1    Bock, G.H.2    Leffers, N.3    Daemen, T.4    Nijman, H.W.5
  • 3
    • 33747762947 scopus 로고    scopus 로고
    • Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor
    • Lopes JE, Torgerson TR, Schubert LA, Anover SD, Ocheltree EL, Ochs HD, et al. Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J Immunol. 2006;177(5):3133-42.
    • (2006) J Immunol , vol.177 , Issue.5 , pp. 3133-3142
    • Lopes, J.E.1    Torgerson, T.R.2    Schubert, L.A.3    Anover, S.D.4    Ocheltree, E.L.5    Ochs, H.D.6
  • 4
    • 28244447468 scopus 로고    scopus 로고
    • CD4 + CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells
    • DiPaolo RJ, Glass DD, Bijwaard KE, Shevach EM. CD4 + CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells. J Immunol. 2005;175(11):7135-42.
    • (2005) J Immunol , vol.175 , Issue.11 , pp. 7135-7142
    • DiPaolo, R.J.1    Glass, D.D.2    Bijwaard, K.E.3    Shevach, E.M.4
  • 5
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity. 2009;30(5):616-25.
    • (2009) Immunity , vol.30 , Issue.5 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 6
    • 65949111746 scopus 로고    scopus 로고
    • FOXP3 defines regulatory T cells in human tumor and autoimmune disease
    • Kryczek I, Liu R, Wang G, Wu K, Shu X, Szeliga W, et al. FOXP3 defines regulatory T cells in human tumor and autoimmune disease. Cancer Res. 2009;69(9):3995-4000.
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 3995-4000
    • Kryczek, I.1    Liu, R.2    Wang, G.3    Wu, K.4    Shu, X.5    Szeliga, W.6
  • 7
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609):1057-61.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 8
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells. Nat Immunol. 2003;4(4):330-6.
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 9
    • 33746599842 scopus 로고    scopus 로고
    • Regulatory T cells in cancer
    • Beyer M, Schultze JL. Regulatory T cells in cancer. Blood. 2006;108(3):804-11.
    • (2006) Blood , vol.108 , Issue.3 , pp. 804-811
    • Beyer, M.1    Schultze, J.L.2
  • 11
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10(9):942-9.
    • (2004) Nat Med , vol.10 , Issue.9 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 12
    • 84911473583 scopus 로고    scopus 로고
    • FOXP3 expression in tumor cells and tumor-infiltrating lymphocytes is associated with breast cancer prognosis
    • Takenaka M, Seki N, Toh U, Hattori S, Kawahara A, Yamaguchi T, et al. FOXP3 expression in tumor cells and tumor-infiltrating lymphocytes is associated with breast cancer prognosis. Mol Clin Oncol. 2013;1(4):625-32.
    • (2013) Mol Clin Oncol , vol.1 , Issue.4 , pp. 625-632
    • Takenaka, M.1    Seki, N.2    Toh, U.3    Hattori, S.4    Kawahara, A.5    Yamaguchi, T.6
  • 13
    • 84896488675 scopus 로고    scopus 로고
    • PD-1(+) immune cell infiltration inversely correlates with survival of operable breast cancer patients
    • Sun S, Fei X, Mao Y, Wang X, Garfield DH, Huang O, et al. PD-1(+) immune cell infiltration inversely correlates with survival of operable breast cancer patients. Cancer Immunol Immunother. 2014;63(4):395-406.
    • (2014) Cancer Immunol Immunother , vol.63 , Issue.4 , pp. 395-406
    • Sun, S.1    Fei, X.2    Mao, Y.3    Wang, X.4    Garfield, D.H.5    Huang, O.6
  • 14
    • 84894043333 scopus 로고    scopus 로고
    • Expression of B7-H3, a potential factor of tumor immune evasion in combination with the number of regulatory T cells, affects against recurrence-free survival in breast cancer patients
    • Maeda N, Yoshimura K, Yamamoto S, Kuramasu A, Inoue M, Suzuki N, et al. Expression of B7-H3, a potential factor of tumor immune evasion in combination with the number of regulatory T cells, affects against recurrence-free survival in breast cancer patients. Ann Surg Oncol. 2014;21(Suppl 4):546-54.
    • (2014) Ann Surg Oncol , vol.21 , pp. 546-554
    • Maeda, N.1    Yoshimura, K.2    Yamamoto, S.3    Kuramasu, A.4    Inoue, M.5    Suzuki, N.6
  • 16
    • 77957661914 scopus 로고    scopus 로고
    • Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses
    • Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603-5.
    • (2010) Eur J Epidemiol , vol.25 , Issue.9 , pp. 603-605
    • Stang, A.1
  • 17
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MKTV, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998;17:2815-34.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.T.V.1    Stewart, L.2
  • 18
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007;8:16.
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3    Burdett, S.4    Sydes, M.R.5
  • 19
    • 33646799809 scopus 로고    scopus 로고
    • Systematic reviews on rehabilitation interventions
    • Handoll HH. Systematic reviews on rehabilitation interventions. Arch Phys Med Rehabil. 2006;87(6):875.
    • (2006) Arch Phys Med Rehabil , vol.87 , Issue.6 , pp. 875
    • Handoll, H.H.1
  • 20
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60.
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3    Altman, D.G.4
  • 21
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22(4):719-48.
    • (1959) J Natl Cancer Inst , vol.22 , Issue.4 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 22
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088-101.
    • (1994) Biometrics , vol.50 , Issue.4 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 23
    • 34247261531 scopus 로고    scopus 로고
    • Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    • Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, Harris AL, et al. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol. 2006;24(34):5373-80.
    • (2006) J Clin Oncol , vol.24 , Issue.34 , pp. 5373-5380
    • Bates, G.J.1    Fox, S.B.2    Han, C.3    Leek, R.D.4    Garcia, J.F.5    Harris, A.L.6
  • 24
    • 84898431823 scopus 로고    scopus 로고
    • Zonal difference and prognostic significance of foxp3 regulatory T cell infiltration in breast cancer
    • Kim S, Lee A, Lim W, Park S, Cho MS, Koo H, et al. Zonal difference and prognostic significance of foxp3 regulatory T cell infiltration in breast cancer. J Breast Cancer. 2014;17(1):8-17.
    • (2014) J Breast Cancer , vol.17 , Issue.1 , pp. 8-17
    • Kim, S.1    Lee, A.2    Lim, W.3    Park, S.4    Cho, M.S.5    Koo, H.6
  • 25
    • 84871445958 scopus 로고    scopus 로고
    • Prognostic impact of FOXP3 expression in triple-negative breast cancer
    • Lee S, Cho EY, Park YH, Ahn JS, Im YH. Prognostic impact of FOXP3 expression in triple-negative breast cancer. Acta Oncol. 2013;52(1):73-81.
    • (2013) Acta Oncol , vol.52 , Issue.1 , pp. 73-81
    • Lee, S.1    Cho, E.Y.2    Park, Y.H.3    Ahn, J.S.4    Im, Y.H.5
  • 26
    • 85027940310 scopus 로고    scopus 로고
    • CD8(+) cytotoxic T cell and FOXP3(+) regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes
    • Liu F, Lang R, Zhao J, Zhang X, Pringle GA, Fan Y, et al. CD8(+) cytotoxic T cell and FOXP3(+) regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes. Breast Cancer Res Treat. 2011;130(2):645-55.
    • (2011) Breast Cancer Res Treat , vol.130 , Issue.2 , pp. 645-655
    • Liu, F.1    Lang, R.2    Zhao, J.3    Zhang, X.4    Pringle, G.A.5    Fan, Y.6
  • 27
    • 62449250053 scopus 로고    scopus 로고
    • Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome
    • Gobert M, Treilleux I, Bendriss-Vermare N, Bachelot T, Goddard-Leon S, Arfi V, et al. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res. 2009;69(5):2000-9.
    • (2009) Cancer Res , vol.69 , Issue.5 , pp. 2000-2009
    • Gobert, M.1    Treilleux, I.2    Bendriss-Vermare, N.3    Bachelot, T.4    Goddard-Leon, S.5    Arfi, V.6
  • 28
    • 84890428459 scopus 로고    scopus 로고
    • Predictive and prognostic factors in locally advanced breast cancer: effect of intratumoral FOXP3+ Tregs
    • Demir L, Yigit S, Ellidokuz H, Erten C, Somali I, Kucukzeybek Y, et al. Predictive and prognostic factors in locally advanced breast cancer: effect of intratumoral FOXP3+ Tregs. Clin Exp Metastasis. 2013;30(8):1047-62.
    • (2013) Clin Exp Metastasis , vol.30 , Issue.8 , pp. 1047-1062
    • Demir, L.1    Yigit, S.2    Ellidokuz, H.3    Erten, C.4    Somali, I.5    Kucukzeybek, Y.6
  • 29
    • 84908116528 scopus 로고    scopus 로고
    • Prognostic significance of FOXP3+ tumor infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration
    • Liu S, Foulkes WD, Leung S, Gao D, Lau S, Kos Z, et al. Prognostic significance of FOXP3+ tumor infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration. Breast Cancer Res. 2014;16(5):432.
    • (2014) Breast Cancer Res , vol.16 , Issue.5 , pp. 432
    • Liu, S.1    Foulkes, W.D.2    Leung, S.3    Gao, D.4    Lau, S.5    Kos, Z.6
  • 30
    • 84872608638 scopus 로고    scopus 로고
    • Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer
    • West NR, Kost SE, Martin SD, Milne K, Deleeuw RJ, Nelson BH, et al. Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer. Br J Cancer. 2013;108(1):155-62.
    • (2013) Br J Cancer , vol.108 , Issue.1 , pp. 155-162
    • West, N.R.1    Kost, S.E.2    Martin, S.D.3    Milne, K.4    Deleeuw, R.J.5    Nelson, B.H.6
  • 31
    • 56649102194 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target
    • Bohling SD, Allison KH. Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target. Mod Pathol. 2008;21(12):1527-32.
    • (2008) Mod Pathol , vol.21 , Issue.12 , pp. 1527-1532
    • Bohling, S.D.1    Allison, K.H.2
  • 32
    • 84860390598 scopus 로고    scopus 로고
    • Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers
    • Yan M, Jene N, Byrne D, Millar EK, O'Toole SA, McNeil CM, et al. Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers. Breast Cancer Res. 2011;13(2):R47.
    • (2011) Breast Cancer Res , vol.13 , Issue.2 , pp. R47
    • Yan, M.1    Jene, N.2    Byrne, D.3    Millar, E.K.4    O'Toole, S.A.5    McNeil, C.M.6
  • 33
    • 84912011347 scopus 로고    scopus 로고
    • The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: a meta-analysis
    • Ibrahim EM, Al-Foheidi ME, Al-Mansour MM, Kazkaz GA. The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: a meta-analysis. Breast Cancer Res Treat. 2014;148(3):467-76.
    • (2014) Breast Cancer Res Treat , vol.148 , Issue.3 , pp. 467-476
    • Ibrahim, E.M.1    Al-Foheidi, M.E.2    Al-Mansour, M.M.3    Kazkaz, G.A.4
  • 34
    • 84944699394 scopus 로고    scopus 로고
    • Prognostic and predictive value of tumor-infiltrating lymphocytes in breast cancer: a systematic review and meta-analysis
    • Yu X, Zhang Z, Wang Z, Wu P, Qiu F, Huang J. Prognostic and predictive value of tumor-infiltrating lymphocytes in breast cancer: a systematic review and meta-analysis. Clin Transl Oncol. 2016;18:497-506.
    • (2016) Clin Transl Oncol. , vol.18 , pp. 497-506
    • Yu, X.1    Zhang, Z.2    Wang, Z.3    Wu, P.4    Qiu, F.5    Huang, J.6
  • 35
    • 0032476616 scopus 로고    scopus 로고
    • Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes
    • Romero P, Dunbar PR, Valmori D, Pittet M, Ogg GS, Rimoldi D, Chen DL JL, Cerottini JC, Cerundolo V. Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes. J Exp Med. 1998;188:1641.
    • (1998) J Exp Med , vol.188 , pp. 1641
    • Romero, P.1    Dunbar, P.R.2    Valmori, D.3    Pittet, M.4    Ogg, G.S.5    Rimoldi, D.6    Chen DL, J.L.7    Cerottini, J.C.8    Cerundolo, V.9
  • 36
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4 + CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4 + CD25+ T regulatory cells. Nat Immunol. 2003;4(4):337-42.
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 37
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma
    • Liyanage UK, Moore TT, Joo HG, Tanaka Y, Herrmann V, Doherty G, et al. Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma. J Immunol. 2002;169(5):2756-61.
    • (2002) J Immunol , vol.169 , Issue.5 , pp. 2756-2761
    • Liyanage, U.K.1    Moore, T.T.2    Joo, H.G.3    Tanaka, Y.4    Herrmann, V.5    Doherty, G.6
  • 38
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T, cells, tumour immunity and immunotherapy
    • Zou W. Regulatory T, cells, tumour immunity and immunotherapy. Nat Rev Immunol. 2006;6(4):295-307.
    • (2006) Nat Rev Immunol , vol.6 , Issue.4 , pp. 295-307
    • Zou, W.1
  • 39
    • 3142737258 scopus 로고    scopus 로고
    • Foxp3 Expressing CD4 + CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells
    • Viguier M, Lemaitre F, Verola O, Cho MS, Gorochov G, Dubertret L, et al. Foxp3 Expressing CD4 + CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells. J Immunol. 2004;173(2):1444-53.
    • (2004) J Immunol , vol.173 , Issue.2 , pp. 1444-1453
    • Viguier, M.1    Lemaitre, F.2    Verola, O.3    Cho, M.S.4    Gorochov, G.5    Dubertret, L.6
  • 41
    • 2442450433 scopus 로고    scopus 로고
    • IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    • Vieira PL, Christensen JR, Minaee S, O'Neill EJ, Barrat FJ, Boonstra A, et al. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol. 2004;172(10):5986-93.
    • (2004) J Immunol , vol.172 , Issue.10 , pp. 5986-5993
    • Vieira, P.L.1    Christensen, J.R.2    Minaee, S.3    O'Neill, E.J.4    Barrat, F.J.5    Boonstra, A.6
  • 42
    • 84865740252 scopus 로고    scopus 로고
    • Regulatory T cells participate in CD39-mediated protection from renal injury
    • Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, et al. Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol. 2012;42(9):2441-51.
    • (2012) Eur J Immunol , vol.42 , Issue.9 , pp. 2441-2451
    • Wang, Y.M.1    McRae, J.L.2    Robson, S.C.3    Cowan, P.J.4    Zhang, G.Y.5    Hu, M.6
  • 44
    • 84930649133 scopus 로고    scopus 로고
    • Natural killer (NK) cell profiles in blood and tumour in women with large and locally advanced breast cancer (LLABC) and their contribution to a pathological complete response (PCR) in the tumour following neoadjuvant chemotherapy (NAC): differential restoration of blood profiles by NAC and surgery
    • Verma C, Kaewkangsadan V, Eremin JM, Cowley GP, Ilyas M, El-Sheemy MA, et al. Natural killer (NK) cell profiles in blood and tumour in women with large and locally advanced breast cancer (LLABC) and their contribution to a pathological complete response (PCR) in the tumour following neoadjuvant chemotherapy (NAC): differential restoration of blood profiles by NAC and surgery. J Transl Med. 2015;13:180.
    • (2015) J Transl Med , vol.13 , pp. 180
    • Verma, C.1    Kaewkangsadan, V.2    Eremin, J.M.3    Cowley, G.P.4    Ilyas, M.5    El-Sheemy, M.A.6
  • 45
    • 0019403751 scopus 로고
    • Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity
    • Eremin O, Coombs RR, Ashby J. Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity. Br J Cancer. 1981;44(2):166-76.
    • (1981) Br J Cancer , vol.44 , Issue.2 , pp. 166-176
    • Eremin, O.1    Coombs, R.R.2    Ashby, J.3
  • 46
    • 84927023965 scopus 로고    scopus 로고
    • High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer
    • Tiainen S, Tumelius R, Rilla K, Hamalainen K, Tammi M, Tammi R, et al. High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer. Histopathology. 2015;66(6):873-83.
    • (2015) Histopathology , vol.66 , Issue.6 , pp. 873-883
    • Tiainen, S.1    Tumelius, R.2    Rilla, K.3    Hamalainen, K.4    Tammi, M.5    Tammi, R.6


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