ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy

Science Translational Medicine

Volumn 8, Issue 352, 2016, Pages

  Nixon, Mark ^a   Mackenzie, Scott D ^a   Taylor, Ashley I ^a   Homer, Natalie Z M ^b   Livingstone, Dawn E ^a,c   Mouras, Rabah ^c,e   Morgan, Ruth A ^a,d   Mole, Damian J ^b   Stimson, Roland H ^a   Reynolds, Rebecca M ^a   Elfick, Alistair P D ^c   Andrew, Ruth ^a,b   Walker, Brian R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; GLUCOSE; HYDROCORTISONE; INSULIN; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1; GLUCOCORTICOID; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1;

ADDISON DISEASE; ADIPOCYTE; ADIPOSE TISSUE; ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBSTITUTION THERAPY; TISSUE SPECIFICITY; UPREGULATION; ACTIVE TRANSPORT; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; BRAIN; C57BL MOUSE; CELL CULTURE; CONGENITAL ADRENAL HYPERPLASIA; DEFICIENCY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; TRANSLATIONAL RESEARCH;

ADDISON DISEASE; ADIPOSE TISSUE; ADRENAL HYPERPLASIA, CONGENITAL; ADRENOCORTICOTROPIC HORMONE; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BRAIN; CELLS, CULTURED; CORTICOSTERONE; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OBESITY; ORGAN SPECIFICITY; RNA, MESSENGER; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84983499007     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaf9074     Document Type: Article

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