Glucocorticoids turn over slowly in human adipose tissue in vivo

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 10, 2010, Pages 4696-4702

  Hughes, Katherine A ^a   Reynolds, Rebecca M ^a   Andrew, Ruth ^a   Critchley, Hilary O D ^b   Walker, Brian R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; GLUCOCORTICOID; HYDROCORTISONE; TRANSCORTIN;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD SAMPLING; FEMALE; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; NORMAL HUMAN; PERIPHERAL VEIN; PRIORITY JOURNAL; SUBCUTANEOUS FAT; TANDEM MASS SPECTROMETRY;

EID: 77957806219     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0384     Document Type: Article

References (30)

1. Sandeep TC, Andrew R, Homer NZ, Andrews RC, Smith K, Walker BR 2005 Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 54:872-879
2. Stimson RH, Andersson J, Andrew R, Redhead DN, Karpe F, Hayes PC, Olsson T, Walker BR 2009 Cortisol release from adipose tissue by 11β- hydroxysteroid dehydrogenase type 1 in humans. Diabetes 58:46-53
3. Macfarlane DP, Forbes S, Walker BR 2008 Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J Endocrinol 197:189-204
4. Djurhuus CB, Gravholt CH, Nielsen S, Mengel A, Christiansen JS, Schmitz OE, Møller N 2002 Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans. Am J Physiol Endocrinol Metab 283:E172-E177
5. Samra JS, Clark ML, Humphreys SM, MacDonald IA, Bannister PA, Frayn KN 1998 Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue. J Clin Endocrinol Metab 83:626-631
6. Gravholt CH, Dall R, Christiansen JS, Møller N, Schmitz O 2002 Preferential stimulation of abdominal subcutaneous lipolysis after prednisolone exposure in humans. Obes Res 10:774-781
7. Fehér T, Bodrogi L 1982 A comparative study of steroid concentrations in human adipose tissue and the peripheral circulation. Clin Chim Acta 126:135-141
8. Lindsay RS, Wake DJ, Nair S, Bunt J, Livingstone DE, Permana PA, Tataranni PA, Walker BR 2003 Subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 activity and mRNA levels are associated with adiposity and insulinaemia in Pima Indians and Caucasians. J Clin Endocrinol Metab 88:2738-2744
9. Rönquist-Nii Y, Edlund PO 2005 Determination of corticosteroids in tissue samples by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 37:341-350
10. Wake DJ, Rask E, Livingstone DE, Söderberg S, Olsson T, Walker BR 2003 Local and systemic impact of transcriptional upregulation of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab 88:3983-3988
11. Asif AR, Steffgen J, Metten M, Grunewald RW, Müller GA, Bahn A, Burckhardt G, Hagos Y 2005 Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells. Pflugers Arch 450:88-95
12. Karssen AM, Meijer OC, van der Sandt IC, Lucassen PJ, de Lange EC, de Boer AG, de Kloet ER 2001 Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology 142:2686-2694
13. Lackner C, Daufeldt S, Wildt L, Alléra A 1998 Glucocorticoid- recognizing and -effector sites in rat liver plasma membrane. Kinetics of corticosterone uptake by isolated membrane vesicles. III. Specificity and stereospecificity. J Steroid Biochem Mol Biol 64: 69-82
14. Rask E, Olsson T, Söderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR 2001 Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 86:1418-1421
15. Hughes KA, Webster SP, Walker BR 2008 11-β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in type 2 diabetes mellitus and obesity. Expert Opin Investig Drugs 17:481-496
16. Andrew R, Smith K, Jones GC, Walker BR 2002 Distinguishing the activities of 11β-hydroxysteroid dehydrogenases in vivo using isotopically labelled cortisol. J Clin Endocrinol Metab 87: 277-285
17. Ross R, Léger L, Guardo R, De Guise J, Pike BG 1991 Adipose tissue volume measured by magnetic resonance imaging and computerized tomography in rats. J Appl Physiol 70:2164-2172
18. Kitay JI 1961 Sex differences in adrenal cortical secretion in the rat. Endocrinology 68:818-824
19. Kirschbaum C, Wüst S, Hellhammer D 1992 Consistent sex differences in cortisol responses to psychological stress. Psychosom Med 54:648-657
20. Finken MJ, Andrews RC, Andrew R, Walker BR 1999 Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductase but not 11-hydroxysteroid dehydrogenases. J Clin Endocrinol Metab 84:3316-3321
21. Jang C, Obeyesekere VR, Alford FP, Inder WJ 2009 Skeletal muscle 11β hydroxysteroid dehydrogenase type 1 activity is upregulated following elective abdominal surgery. Eur J Endocrinol 160:249-255
22. Andersson T, Simonyte K, Andrew R, Strand M, Burén J, Walker BR, Mattsson C, Olsson T 2009 Tissue-specific increases in 11β-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women. PLoS One 4:e8475
23. Andrew R, Westerbacka J, Wahren J, Yki-Järvinen H, Walker BR 2005 The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes 54:1364-1370
24. Wake DJ, Strand M, Rask E, Westerbacka J, Livingstone DE, Soderberg S, Andrew R, Yki-Jarvinen H, Olsson T, Walker BR 2007 Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol (Oxf) 66:440-446
25. Wake DJ, Homer NZ, Andrew R, Walker BR 2006 Acute in vivo regulation of 11β-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans. J Clin Endocrinol Metab 91:4682-4688
26. White PC, Rogoff D, McMillan DR, Lavery GG 2007 Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism. Mol Cell Endocrinol 265- 266:89-92
27. Frayn KN, Karpe F, Fielding BA, Macdonald IA, Coppack SW 2003 Integrative physiology of human adipose tissue. Int J Obes Relat Metab Disord 27:875-888
28. Bleau G, Roberts KD, Chapdelaine A 1974 The in vitro and in vivo uptake and metabolism of steroids in human adipose tissue. J Clin Endocrinol Metab 39:236-246
29. Droste SK, de Groote L, Atkinson HC, Lightman SL, Reul JM, Linthorst AC 2008 Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress. Endocrinology 149:3244-3253
30. Stavreva DA, Wiench M, John S, Conway-Campbell BL, McKenna MA, Pooley JR, Johnson TA, Voss TC, Lightman SL, Hager GL 2009 Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription. Nat Cell Biol 11:1093-1102