Contribution of CD8+ T cells to inflammatory cytokine production in systemic sclerosis (SSc)

Autoimmunity

Volumn 49, Issue 8, 2016, Pages 532-546

  Klein, Matthias ^a   Schmalzing, Marc ^a   Almanzar, Giovanni ^a   Benoit, Sandrine ^a   Hamm, Henning ^a   Tony, Hans Peter ^a   Goebeler, Matthias ^a   Prelog, Martina ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

CD8+; chemokine receptors; cytokines; systemic sclerosis; T cells

Indexed keywords

AZATHIOPRINE; CD161 ANTIGEN; CD28 ANTIGEN; CD31 ANTIGEN; CD45RA ANTIGEN; CENTROMERE ANTIBODY; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; CYCLOPHOSPHAMIDE; GAMMA INTERFERON; GLUCOCORTICOID; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 7 RECEPTOR; METHOTREXATE; PREDNISONE; SCL 70 ANTIBODY; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TUMOR NECROSIS FACTOR; AUTACOID; AUTOANTIBODY; BIOLOGICAL MARKER; CYTOKINE;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY T LYMPHOCYTE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SYSTEMIC SCLEROSIS; T LYMPHOCYTE SUBPOPULATION; BLOOD; CASE CONTROL STUDY; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; PHENOTYPE;

ADULT; AGED; AUTOANTIBODIES; BIOMARKERS; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; HUMANS; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PHENOTYPE; RECEPTORS, CHEMOKINE; SCLERODERMA, SYSTEMIC; T-LYMPHOCYTE SUBSETS;

EID: 84983474677     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916934.2016.1217997     Document Type: Article

References (60)

1. Müller-Ladner, U., O., Distler, L., Ibba-Manneschi, et al. 2009. Mechanisms of vascular damage in systemic sclerosis. Autoimmunity 42:597–595
2. Sakkas, L. I., 2005. New developments in the pathogenesis of systemic sclerosis. Autoimmunity 38:113–116
3. Radstake, T. R., L., van Bon, J., Broen, et al. 2009. The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One 4:e5903
4. Radstake, T. R., L., van Bon, J., Broen, et al. 2009. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One 4:e5981
5. Kurzinski, K., K. S., Torok. 2011. Cytokine profiles in localized scleroderma and relationship to clinical features. Cytokine 55:157–164
6. Baraut, J., L., Michel, F., Verrecchia, and D., Farge. 2010. Relationship between cytokine profiles and clinical outcomes in patients with systemic sclerosis. Autoimmun. Rev. 10:65–73
7. Papp, G., I. F., Horvath, S., Barath, et al. 2011. Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis. Scand. J. Rheumatol. 40:205–210
8. Fenoglio, D., F., Battaglia, A., Parodi, et al. 2011. Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis. Clin. Immunol. 139:249–257
9. Mathian, A., C., Parizot, K., Dorgham, et al. 2012. Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions. Ann. Rheum. Dis. 71:1227–1234
10. Fuschiotti, P., T. A., Medsger Jr, and P. A., Morel. 2009. Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis. Arthritis. Rheum. 60:1119–1128
11. Boin, F., F. M., Wigley, J. P., Schneck, et al. 2005. Evaluation of topoisomerase-1-specific CD8+ T-cell response in systemic sclerosis. Ann. N. Y. Acad. Sci. 1062:137–145
12. Ercole, L. P., M., Malvezzi, A. C., Boaretti, et al. 2003. Analysis of lymphocyte subpopulations in systemic sclerosis. J. Investig. Allergol. Clin. Immunol. 13:87–93
13. Atamas, S. P., V. V., Yurovsky, R., Wise, et al. 1999. Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis. Rheum. 42:1168–1178
14. Kessel, A., I., Rosner, M., Rozenbaum, et al. 2004. Increased CD8+ T cell apoptosis in scleroderma is associated with low levels of NF-kappa B. J. Clin. Immunol. 24:30–36
15. Gambichler, T., C., Tigges, B., Burkert, et al. 2010. Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis. Eur. J. Med. Res. 15:44–46
16. Filaci, G., M., Fravega, D., Fenoglio, et al. 2004. Non-antigen specific CD8+ T suppressor lymphocytes. Clin. Exp. Med. 4:86–92
17. Fergusson, J. R., V. M., Fleming, and P., Klenerman. 2011. CD161-expressing human T cells. Front. Immunol. 2:1–7
18. Mitsuo, A., S., Morimoto, Y., Nakiri, et al. 2006. Decreased CD161 + CD8+ T cells in the peripheral blood of patients suffering from rheumatic diseases. Rheumatology (Oxford) 45:1477–1484
19. Parel, Y., M., Aurrand-Lions, A., Scheja, et al. 2007. Presence of CD4 + CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis. Arthritis Rheum. 56:3459–3467
20. Medsger, T. A., Jr., D. E., Ivanco, L., Kardava, et al. 2011. GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production. Arthritis Rheum. 63:1738–1747
21. Fuschiotti, P., 2011. CD8+ T cells in systemic sclerosis. Immunol. Res. 50:188–194
22. Fuschiotti, P., A. T., Larregina, J., Ho, et al. 2013. Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis. Arthritis Rheum. 65:236–246
23. Hasegawa, M. S., and S., Sato. 2008. The roles of chemokines in leukocyte recruitment and fibrosis in systemic sclerosis. Front. Biosci. 13:3637–3647
24. Truchetet, M. E., N. C., Brembilla, E., Montanari, et al. 2011. Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis:association with interstitial lung disease. Arthritis Res. Ther. 13:R166
25. Tao, J., L., Li, Z., Tan, et al. 2011. Up-regulation of CC chemokine ligand 20 and its receptor CCR6 in the lesional skin of early systemic sclerosis. Eur. J. Dermatol. 21:731–736
26. van den Hoogen, F., D., Khanna, J., Fransen, et al. 2013. 2013 classification criteria for systemic sclerosis:an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum. 65:2737–2747
27. Hachulla, E., and D., Launay. 2011. Diagnosis and classification of systemic sclerosis. Clin. Rev. Allergy Immunol. 40:78–83
28. Distler, J. H., A., Akhmetshina, G., Schett, and O., Distler. 2009. Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis. Rheumatology (Oxford) 48:98–103
29. Kimmig, S., G. K., Przybylski, C. A., Schmidt, et al. 2002. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J. Exp. Med. 195:789–794
30. Fink, P. J., 2013. The biology of recent thymic emigrants. Annu. Rev. Immunol. 31:31–50
31. Fujii, H., M., Hasegawa, K., Takehara, et al. 2002. Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T lymphocytes from patients with systemic sclerosis. Clin. Exp. Immunol. 130:548–556
32. Hickman, H. D., G. V., Reynoso, B. F., Ngudiankama, et al. 2015. CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells. Immunity 42:524–537
33. Oghumu, S., C. A., Terrazas, S., Varikuti, et al. 2015. CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15. Faseb. J. 29:1019–1028
34. Villarroel, V. A., N., Okiyama, G., Tsuji, et al. 2014. CXCR3-mediated skin homing of autoreactive CD8 T cells is a key determinant in murine graft-versus-host disease. J. Invest. Dermatol. 134:1552–1560
35. Yaqub, A., L., Chung, K. E., Rieger, and D. F., Fiorentino. 2013. Localized cutaneous fibrosing disorders. Rheum. Dis. Clin. North Am. 39:347–364
36. Oo, Y. H., V., Banz, D., Kavanagh, et al. 2012. CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J. Hepatol. 57:1044–1051
37. van der Waart, A. B., W. J., van der Velden, A. G., van Halteren, et al. 2012. Decreased levels of circulating IL17-producing CD161 + CCR6+ T cells are associated with graft-versus-host disease after allogeneic stem cell transplantation. Plos One 7:e50896
38. Billerbeck, E., Y. H., Kang, L., Walker, et al. 2010. Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc. Natl. Acad. Sci. USA 107:3006–3011
39. Wehrens, E. J., G., Mijnheer, C. L., Duurland, et al. 2011. Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. Blood 118:3538–3548
40. Xie, Y., Zhang, X., Wakasugi, S., et al. 2008. Immunohistochemical characterization of the cellular infiltrate in localized scleroderma. Int. J. Dermatol. 47:438–442
41. Li, H., and A., Rostami. 2010. IL-9:basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity. J. Neuroimmune Pharmacol. 5:198–209
42. Visekruna, A., J., Ritter, T., Scholz, et al. 2013. Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Eur. J. Immunol. 43:606–518
43. Nowak, E. C., and R. J., Noelle. 2010. Interleukin-9 as a T helper type 17 cytokine. Immunology 131:169–173
44. Lu, Y., S., Hong, H., Li, et al. 2012. Th9 cells promote antitumor immune responses in vivo. J. Clin. Invest. 122:4160–4171
45. Yanaba, K., A., Yoshizaki, Y., Asano, et al. 2011. Serum interleukin 9 levels are increased in patients with systemic sclerosis:association with lower frequency and severity of pulmonary fibrosis. J. Rheumatol. 38:2193–2197
46. Macaulay, R., A. N., Akbar, and S. M., Henson. 2013. The role of the T cell in age-related inflammation. Age (Dordr) 35:563–572
47. Mayerl, C., and M., Prelog. 2012. Immunosenescence and juvenile idiopathic arthritis. Autoimmun. Rev. 11:297–300
48. Prelog, M., N., Schwarzenbrunner, M., Sailer-Höck, et al. 2008. Premature aging of the immune system in children with juvenile idiopathic arthritis. Arthritis Rheum. 58:2153–2162
49. Prelog, M., 2006. Aging of the immune system:a risk factor for autoimmunity? Autoimmun. Rev. 5:136–139
50. Moore, K. W., R., de Waal Malefyt, R. L., Coffman, and A., O'Garra. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19:683–765
51. Fahey, L. M., and D. G., Brooks. 2010. Opposing positive and negative regulation of T cell activity during viral persistence. Curr. Opin. Immunol. 22:348–354
52. Gravano, D. M., and K. K., Hoyer. 2013. Promotion and prevention of autoimmune disease by CD8+ T cells. J. Autoimmun. 45:68–79
53. Masson, F., M., Ghisi, J. R., Groom, et al. 2014. Id2 represses E2A-mediated activation of IL-10 expression in T cells. Blood 123:3420–3428
54. Herman, S., N., Zurgil, P., Langevitz, et al. 2008. Methotrexate selectively modulates TH1/TH2 balance in active rheumatoid arthritis patients. Clin. Exp. Rheumatol. 26:317–323
55. Guggino, G., A., Giardina, A., Ferrante, et al. 2015. The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis. Rheumatol. Int. 35:171–175
56. Zhang, Z., P., Zhao, A., Li, et al. 2009. Effects of methotrexate on plasma cytokines and cardiac remodeling and function in postmyocarditis rats. Mediators Inflamm. 2009:389720
57. Thomaz, M. A., S. C., Acedo, C. C., de Oliveira, et al. 2009. Methotrexate is effective in reactivated colitis and reduces inflammatory alterations in mesenteric adipose tissue during intestinal inflammation. Pharmacol. Res. 60:341–346
58. + ratio and Tregs in spleen and thymus in collagen-induced arthritis. Inflamm. Res. 61:1229–1239
59. Zhang, S., Z., Shen, G., Hu, et al. 2009. Effects of endogenous glucocorticoids on allergic inflammation and T(H)1 /T(H)2 balance in airway allergic disease. Ann. Allergy Asthma Immunol. 103:525–534
60. Muangchan, C., Canadian Scleroderma Research Group, Baron M, Pope J., 2013. The 15% rule in scleroderma:the frequency of severe organ complications in systemic sclerosis. A systematic review. J. Rheumatol. 40:1545–1556