Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis

European Journal of Medical Research

Volumn 15, Issue 1, 2010, Pages 44-46

  Gambichler, Thilo ^a   Tigges, C ^a   Burkert, B ^a   Hoxtermann S ^a   Altmeyer, P ^a   Kreuter, A ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN;

ADULT; ARTICLE; B LYMPHOCYTE; CD19+ T LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD56+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; PROSPECTIVE STUDY; SYSTEMIC SCLEROSIS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 77149124269     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: 10.1186/2047-783x-15-1-44     Document Type: Article

References (15)

1. Leroy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol. 1988;15:202-205.
2. Melendro EI, Saldate C, Rivero SJ, Alarcon-Segovia D. T-cell subpopulations in the peripheral blood of patients with connective tissue diseases as determined by flow cytometry using monoclonal antibodies. Clin Immunol Immunopathol. 1983;27:340-7.
3. Dalkiliç E, Dilek K, Güllülü M, Yavuz M, Karakoç Y, Yurtkuran M, et al. Lymphocyte phenotypes in systemic sclerosis. Ann Rheum Dis. 1999;58:719-20.
4. Kahan A, Kahan A, Picard F, Menkès CJ, Amor B. Abnormalities of T lymphocyte subsets in systemic sclerosis demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies. Ann Rheum Dis. 1991;50:354-8.
5. Gorla R, Airò P, Malagoli A, Carella G, Prati E, Brugnoni D, Franceschini F, Cattaneo R. CD4+ and CD8+ subsets: naive and memory cells in the peripheral blood of patients with systemic sclerosis. Clin Rheumatol. 1994; 13:83-7.
6. Fiocco U, Rosada M, Cozzi L, Ortolani C, De Silvestro G, Ruffatti A, Cozzi E, Gallo C, Todesco S. Early phenotypic activation of circulating helper memory T cells in scleroderma: correlation with disease activity. Ann Rheum Dis. 1993;52:272-7.
7. Ercole LP, Malvezzi M, Boaretti AC, Utiyama SR, Rachid A. Analysis of lymphocyte subpopulations in systemic sclerosis. J Investig Allergol Clin Immunol. 2003;13:87-93
8. Ingegnoli F, Trabattoni D, Saresella M, Fantini F, Clerici M. Distinct immune profiles characterize patients with diffuse or limited systemic sclerosis. Clin Immunol. 2003; 108:21-8.
9. Artlett CM, Cox LA, Ramos RC, Dennis TN, Fortunato RA, Hummers LK, Jimenez SA, Smith JB. Increased microchimeric CD4+ T lymphocytes in peripheral blood from women with systemic sclerosis. Clin Immunol. 2002;103:303-8.
10. Tsuji-Yamada J, Nakazawa M, Minami M, Sasaki T. Increased frequency of interleukin 4 producing CD4+ and CD8+ cells in peripheral blood from patients with systemic sclerosis. J Rheumatol. 2001;28:1252-8.
11. Riccieri V, Parisi G, Spadaro A, Scrivo R, Barone F, Moretti T, Bernardini G, Strom R, Taccari E, Valesini G. Reduced circulating natural kiler T cells and gamma/delta T cells in patients with systemic sclerosis. J Rheumatol. 2005;32:283-6.
12. Mitsuo A, Morimoto S, Nakiri Y, Suzuki J, Kaneko H, Tokano Y, Tsuda H, Takasaki Y, Hashimoto H. Decreased CD161+CD8+ T cells in the peripheral blood of patients suffering from rheumatic diseases. Rheumatology (Oxford). 2006;45:1477-84.
13. Sato S, Fujimoto M, Hasegawa M, Takehara K. Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells. Arthritis Rheum. 2004;50:1918-27.
14. Balbir-Gurman A, Denton CP, Nichols B, Knight CJ, Nahir AM, et al. Non-invasive measurement of biomechanical skin properties in systemic sclerosis. Ann Rheum Dis 2002;61:237-41.
15. Majone F, Olivieri S, Cozzi F, Montaldi A, Tonello M, Visentin MS, Ciprian L, Ruffatti A. Increased apoptosis in circulating lymphocyte cultures of anti-RNA polymerase III positive patients with systemic sclerosis. Rheumatol Int. 2008 Dec 3. [Epub ahead of print]