Decrease in somatostatin-positive cell density in the amygdala of females with major depression

Depression and Anxiety

Volumn 34, Issue 1, 2017, Pages 68-78

  Douillard Guilloux, Gaelle ^a   Lewis, David ^a,b   Seney, Marianne L ^a   Sibille, Etienne ^a,b,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

biological markers; depression; gender; genetics; mood disorders

Indexed keywords

MESSENGER RNA; SOMATOSTATIN; 4 AMINOBUTYRIC ACID RECEPTOR;

ADULT; AMYGDALA; ARTICLE; BASOLATERAL AMYGDALA; BRAIN NERVE CELL; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; MAJOR DEPRESSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; AUTOPSY; CELL COUNT; CYTOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AMYGDALA; AUTOPSY; CELL COUNT; DEPRESSIVE DISORDER, MAJOR; FEMALE; GABAERGIC NEURONS; HUMANS; MIDDLE AGED; SOMATOSTATIN;

EID: 84983435449     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22549     Document Type: Article

References (34)

1. Agren, H., & Lundqvist, G. (1984). Low levels of somatostatin in human CSF mark depressive episodes. Psychoneuroendocrinology, 9(3), 233–248.
2. Beneyto, M., Sibille, E., & Lewis, D. A. (2008). Human postmortem brain research in mental illness syndromes. In: D. S. Charney, E. J. Nestler (Eds.), Neurobiology of mental illness (pp. 202–214). New York: Oxford University Press.
3. Bissette, G., Widerlov, E., Walleus, H., Karlsson, I., Eklund, K., Forsman, A., & Nemeroff, C. B. (1986). Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders. Archives of General Psychiatry, 43(12), 1148–1151.
4. Davies, P., & Terry, R. D. (1981). Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type. Neurobiology of Aging, 2(1), 9–14.
5. Dupont, E., Christensen, S. E., Hansen, A. P., de Fine Olivarius, B., & Orskov, H. (1982). Low cerebrospinal fluid somatostatin in Parkinson disease: An irreversible abnormality. Neurology, 32(3), 312–314.
6. Gahete, M. D., Rubio, A., Duran-Prado, M., Avila, J., Luque, R. M., & Castano, J. P. (2010). Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients. Journal of Alzheimers Disease, 20(2), 465–475.
7. Glantz, L. A., Austin, M. C., & Lewis, D. A. (2000). Normal cellular levels of synaptophysin mRNA expression in the prefrontal cortex of subjects with schizophrenia. Biological Psychiatry, 48(5), 389–397.
8. Glorioso, C., Oh, S., Douillard, G. G., & Sibille, E. (2011). Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism. Neurobiology of Disease, 41(2), 279–290.
9. Guilloux, J. P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K.,.. Sibille, E. (2012). Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Molecular Psychiatry, 17(11), 1130–1142.
10. Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62(6), 593–602.
11. Kling, M. A., Rubinow, D. R., Doran, A. R., Roy, A., Davis, C. L., Calabrese, J. R.,.. Gold, P. W. (1993). Cerebrospinal fluid immunoreactive somatostatin concentrations in patients with Cushing's disease and major depression: Relationship to indices of corticotropin-releasing hormone and cortisol secretion. Neuroendocrinology, 57(1), 79–88.
12. Konradi, C., Zimmerman, E. I., Yang, C. K., Lohmann, K. M., Gresch, P., Pantazopoulos, H.,.. Heckers, S. (2011). Hippocampal Interneurons in Bipolar Disorder. Archives of General Psychiatry, 68(4), 340–350.
13. Kornstein, S. G., Schatzberg, A. F., Thase, M. E., Yonkers, K. A., McCullough, J. P., Keitner, G. I.,.. Keller, M. B. (2000). Gender differences in treatment response to sertraline versus imipramine in chronic depression. American Journal of Psychiatry, 157(9), 1445–1452.
14. Lewis, D. A., Campbell, M. J., & Morrison, J. H. (1986). An immunohistochemical characterization of somatostatin-28 and somatostatin-281-12 in monkey prefrontal cortex. Journal of Comparative Neurology, 248(1), 1–18.
15. Lin, L. C., Lewis, D. A., & Sibille, E. (2011). A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism. Molecular Brain, 4, 18.
16. Lin, L. C., & Sibille, E. (2015). Somatostatin, neuronal vulnerability and behavioral emotionality. Molecular Psychiatry, 20(3), 377–387.
17. Ma, Y., Hu, H., Berrebi, A. S., Mathers, P. H., & Agmon, A. (2006). Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice. Journal of Neuroscience, 26(19), 5069–5082.
18. McDonald, A. J., & Mascagni, F. (2002). Immunohistochemical characterization of somatostatin containing interneurons in the rat basolateral amygdala. Brain Research, 943(2), 237–244.
19. McDonald, A. J., Mascagni, F., & Zaric, V. (2012). Subpopulations of somatostatin-immunoreactive non-pyramidal neurons in the amygdala and adjacent external capsule project to the basal forebrain: Evidence for the existence of GABAergic projection neurons in the cortical nuclei and basolateral nuclear complex. Frontiers in Neural Circuits, 6, 46.
20. Molchan, S. E., Hill, J. L., Martinez, R. A., Lawlor, B. A., Mellow, A. M., Rubinow, D. R.,.. Sunderland, T. (1993). CSF somatostatin in Alzheimer's disease and major depression: Relationship to hypothalamic-pituitary-adrenal axis and clinical measures. Psychoneuroendocrinology, 18(7), 509–519.
21. Morris, H. M., Hashimoto, T., & Lewis, D. A. (2008). Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder. Cerebral Cortex, 18(7), 1575–1587.
22. Muller, J. F., Mascagni, F., & McDonald, A. J. (2007). Postsynaptic targets of somatostatin-containing interneurons in the rat basolateral amygdala. J Comparative Neurology, 500(3), 513–529.
23. Pitkanen, A., Savander, V., & LeDoux, J. E. (1997). Organization of intra-amygdaloid circuitries in the rat: An emerging framework for understanding functions of the amygdala. Trends in Neurosciences, 20(11), 517–523.
24. Roussel, B. D., Kruppa, A. J., Miranda, E., Crowther, D. C., Lomas, D. A., & Marciniak, S. J. (2013). Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurology, 12(1), 105–118.
25. Seney, M. L., Chang, L. C., Oh, H., Wang, X., Tseng, G. C., Lewis, D. A., & Sibille, E. (2013). The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species. Frontiers in Psychiatry, 4, 104.
26. Seney, M. L., Ekong, K. I., Ding, Y., Tseng, G. C., & Sibille, E. (2013). Sex chromosome complement regulates expression of mood-related genes. Biology of Sex Differences, 4(1), 20.
27. Seney, M. L., Tripp, A., McCune, S., Lewis, D. A., & Sibille, E. (2015). Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression. Neurobiology of Disease, 73, 213–219.
28. Sibille, E., Morris, H. M., Kota, R. S., & Lewis, D. A. (2011). GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders. International Journal of Neuropsychopharmacology, 14(6), 721–734.
29. Sibille, E., Wang, Y., Joeyen-Waldorf, J., Gaiteri, C., Surget, A., Oh, S.,.. Lewis, D. A. (2009). A molecular signature of depression in the amygdala. American journal of psychiatry, 166(9), 1011–1024.
30. Sorvari, H., Soininen, H., Paljarvi, L., Karkola, K., & Pitkanen, A. (1995). Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex. Journal of Comparative Neurology, 360(2), 185–212.
31. Sosulina, L., Graebenitz, S., & Pape, H. C. (2010). GABAergic interneurons in the mouse lateral amygdala: A classification study. Journal of Neurophysiology, 104(2), 617–626.
32. Tripp, A., Kota, R. S., Lewis, D. A., & Sibille, E. (2011). Reduced somatostatin in subgenual anterior cingulate cortex in major depression. Neurobiology of Disease, 42(1), 116–124.
33. Viollet, C., Lepousez, G., Loudes, C., Videau, C., Simon, A., & Epelbaum, J. (2008). Somatostatinergic systems in brain: Networks and functions. Molecular and Cellular Endocrinology, 286(1-2), 75–87.
34. Weckbecker, G., Lewis, I., Albert, R., Schmid, H. A., Hoyer, D., & Bruns, C. (2003). Opportunities in somatostatin research: Biological, chemical and therapeutic aspects. Nature Reviews Drug Discovery, 2(12), 999–1017.