Normal cellular levels of synaptophysin mRNA expression in the prefrontal cortex of subjects with schizophrenia

Biological Psychiatry

Volumn 48, Issue 5, 2000, Pages 389-397

  Glantz, Leisa A ^a   Austin, Mark C ^a   Lewis, David A ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Prefrontal cortex; Schizophrenia; Synaptic proteins; Synaptophysin; Thalamus

Indexed keywords

SYNAPTOPHYSIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCHIZOPHRENIA; SYNAPSE VESICLE;

ADULT; CELL SIZE; FEMALE; HUMANS; IN SITU HYBRIDIZATION; MALE; PREFRONTAL CORTEX; RNA, MESSENGER; SCHIZOPHRENIA; SYNAPTOPHYSIN; THALAMUS;

EID: 0034283026     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(00)00923-9     Document Type: Article

References (52)

1. Akbarian S., Kim J.J., Potkin S.G., Hagman J.O., Tafazzoli A., Bunney W.E. Jr, et al. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry. 52:1995;258-266.
2. Andreasen N.C., Arndt S., Swayze V. II, Cizaldo T., Flaum M., O'Leary D., et al. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science. 266:1994;294-298.
3. Andreasen N.C., Flashman L., Flaum M., Arndt S., Swayze V. II, O'Leary D.S., et al. Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA. 272:1994;1763-1769.
4. Barbas H. Architecture and cortical connections of the prefrontal cortex in the Rhesus monkey. Adv Neurol. 57:1992;91-115.
5. Bertolino A., Callicott J.H., Nawroz S., Mattay V.S., Duyn J.H., Tecleschi G., et al. Reproducibility of proton magnetic resonance spectroscopic imaging in patients with schizophrenia. Neuropsychopharmacology. 18:1998;1-9.
6. Bertolino A., Nawroz S., Mattay V.S., Barnett A.S., Duyn J.H., Moonen C.T.W., et al. Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am J Psychiatry. 153:1996;1554-1563.
7. Daly C., Ziff E.B. Post-transcriptional regulation of synaptic vesicle protein expression and the developmental control of synaptic vesicle formation. J Neurosci. 17:1997;2365-2375.
8. Davidsson P., Gottfries J., Bogdanovic N., Ekman R., Karlsson I., Gottfries C.-G., et al. The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains. Schizophr Res. 40:1999;23-29.
9. Daviss S.R., Lewis D.A. Local circuit neurons of the prefrontal cortex in schizophrenia Selective increase in the density of calbindin-immunoreactive neurons . Psychiatry Res. 59:1995;81-96.
10. Eastwood S.L., Harrison P.J. Hippocampal and cortical growth-associated protein-43 messenger RNA in schizophrenia. Neuroscience. 86:1998;437-448.
11. Gabriel S.M., Haroutunian V., Powchik P., Honer W.G., Davidson M., Davies P., et al. Increased concentrations of presynaptic proteins in the cingulate cortex of subjects with schizophrenia. Arch Gen Psychiatry. 54:1997;559-566.
12. Garey L.J., Ong W.Y., Patel T.S., Kanani M., Davis A., Mortimer A.M., et al. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J Neurol Neurosurg Psychiatry. 65:1998;446-453.
13. Glantz L.A., Lewis D.A. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia Regional and diagnostic specificity . Arch Gen Psychiatry. 54:1997;943-952.
14. Glantz L.A., Lewis D.A. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry. 57:2000;65-73.
15. Goldman-Rakic P.S. Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. Plum F., Mountcastle V., Handbook of Physiology. 1987;373-417 American Physiological Society, Bethesda, MD.
16. Goldman-Rakic P.S., Selemon L.D. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr Bull. 23:1997;437-458.
17. Goldstein J.M., Goodman J.M., Seidman L.J., Kennedy D.N., Makris N., Lee H., et al. Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Arch Gen Psychiatry. 56:1999;537-547.
18. Guillery R.W., Herrup K. Quantification without pontification Choosing a method for counting objects in sectioned tissues . J Comp Neurol. 386:1997;2-7.
19. Hamos J.E., DeGennaro L.J., Drachman D.A. Synaptic loss in Alzheimer's disease and other dementias. Neurology. 39:1989;355-361.
20. Harrison P.J., Heath P.R., Eastwood S.L., Burnet P.W.J., McDonald B., Pearson R.C.A. The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies Selective mRNA vulnerability and comparison with their encoded proteins . Neurosci Lett. 200:1995;151-154.
21. Honer W.G., Falkai P., Chen C., Arango V., Mann J.J., Dwork A.J. Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness. Neuroscience. 91:1999;1247-1255.
22. Jahn R., Schiebler W., Ouimet C., Greengard P. A 38,000-dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci U S A. 82:1985;4137-4141.
23. Karson C.N., Mrak R.E., Schluterman K.O., Sturner W.Q., Sheng J.G., Griffin W.S.T. Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophenia A possible neurochemical basis for "hypofrontality" Mol Psychiatry. 4:1999;39-45.
24. Levitt J.B., Lewis D.A., Yoshioka T., Lund J.S. Topography of pyramidal neuron intrinsic connections in macaque monkey prefrontal cortex (areas 9 & 46). J Comp Neurol. 338:1993;360-376.
25. Lewis D.A. Development of the prefrontal cortex during adolescence Insights into vulnerable neural circuits in schizophrenia . Neuropsychopharmacology. 16:1997;385-398.
26. Littell R.C., Milliken G.A., Stroup W.W., Wolfinger R.D. SAS System for Mixed Models. 1996;SAS Institute, Cary, NC.
27. Manaye K.F., Liang C.-L., Hicks P.B., German D., Young K.A. Nerve cell numbers in thalamic anterior and mediodorsal nuclei are selectively reduced in schizophrenia. Soc Neurosci Abstr. 24:1998;1236.
28. Masliah E., Terry R.D., Alford M., DeTeresa R. Quantitative immunohistochemistry of synaptophysin in human neocortex An alternative method to estimate density of presynaptic terminals in paraffin sections . J Histochem Cytochem. 38:1990;837-844.
29. Melchitzky D.S., Sesack S.R., Pucak M.L., Lewis D.A. Synaptic targets of pyramidal neurons providing intrinsic horizontal connections in monkey prefrontal cortex. J Comp Neurol. 390:1998;211-224.
30. Melloni R.H. Jr, Hemmendinger L.M., Hamos J.E., DeGennero L.J. Synapsin I gene expression in the adult brain with comparative analysis of mRNA and protein in the hippocampus. J Comp Neurol. 327:1993;507-520.
31. Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., et al. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology. 41:1991;479-486.
32. Mitchell I.J., Cross A.J., Sambrook M.A., Crossman A.R. Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus. Neurosci Lett. 61:1985;195-200.
33. Neter J, Kutner MH, Nachtsheim CJ, Wasserman W (1996): Applied Linear Statistical Models, 4th ed. Chicago: Irwin.
34. Pakkenberg B. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch Gen Psychiatry. 47:1990;1023-1028.
35. Perrone-Bizzozero N.I., Sower A.C., Bird E.D., Benowitz L.I., Ivins K.J., Neve R.L. Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia. Proc Natl Acad Sci U S A. 93:1996;14182-14187.
36. Pierri J.N., Edgar C.L., Lewis D.A. Somal size of pyramidal neurons in deep layer 3 of prefrontal cortex of subjects with schizophrenia. Schizophr Res. 36:1999;84.
37. Popken G.J., Bunney W.E. Jr, Potkin S.G., Jones E.G. Neuron number and GABAergic and glutamatergic mRNA expression in subdivisions of the thalamic mediodorsal nucleus of schizophrenics. Soc Neurosci Abstr. 24:1998;991.
38. Rajkowska G., Goldman-Rakic P.S. Cytoarchitectonic definition of prefrontal areas in the normal human cortex I. Remapping of areas 9 and 46 using quantitative criteria . Cereb Cortex. 5:1995;307-322.
39. Rajkowska G., Selemon L.D., Goldman-Rakic P.S. Neuronal and glial somal size in the prefrontal cortex A postmortem morphometric study of schizophrenia and Huntington disease . Arch Gen Psychiatry. 55:1998;215-224.
40. Rodriguez R.M., Weickert C.S., Herman M.M., Hyde T.M., Webster M.J., Weinberger D.R., et al. Synaptophysin mRNA in normal postnatal prefrontal cortex development and in schizophrenia versus normal control. Soc Neurosci Abstr. 24:1998;987.
41. Schlaepfer T.E., Harris G.J., Tien A.Y., Peng L.W., Lee S., Federman E.B., et al. Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry. 151:1994;842-848.
42. Selemon L.D., Goldman-Rakic P.S. The reduced neuropil hypothesis A circuit based model of schizophrenia . Biol Psychiatry. 45:1999;17-25.
43. Selemon L.D., Rajkowska G., Goldman-Rakic P.S. Abnormally high neuronal density in the schizophrenic cortex A morphometric analysis of prefrontal area 9 and occipital area 17 . Arch Gen Psychiatry. 52:1995;805-818.
44. Selemon L.D., Rajkowska G., Goldman-Rakic P.S. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients Application of a three-dimensional, stereologic counting method . J Comp Neurol. 392:1998;402-412.
45. Shelton R.C., Karson C.N., Doran A.R., Pickar D., Bigelow L.B., Weinberger D.R. Cerebral structural pathology in schizophrenia Evidence for a selective prefrontal cortical defect . Am J Psychiatry. 145:1988;154-163.
46. Sudhof T.C., Lottspeich F., Greengard P., Mehl E., Jahn R. The cDNA and derived amino acid sequences for rat and human synaptophysin. Nucleic Acids Res. 15:1987;9607.
47. Sullivan E.V., Lim K.O., Mathalon D., Marsh L., Beal D.M., Harris D., et al. A profile of cortical gray matter volume deficits characteristic of schizophrenia. Cereb Cortex. 8:1998;117-124.
48. 67 mRNA expression in a subset of prefrontal cortical GABA neurons in schizophrenia. Arch Gen Psychiatry. 57:2000;237-245.
49. Weinberger D.R., Aloia M.S., Goldberg T.E., Berman K.F. The frontal lobes and schizophrenia. J Neuropsychiatry Clin Neurosci. 6:1994;419-427.
50. White E.L. Cortical Circuits. Synaptic Organization of the Cerebral Cortex. Structure, Function and Theory. 1989;Birkhäuser, Boston.
51. r 38,000 characteristic of presynaptic vesicles. Cell. 41:1985;1017-1028.
52. Zipursky R.B., Lim K.O., Sullivan E.V., Brown B.W., Pfefferbaum A. Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry. 49:1992;195-205.