-
2
-
-
84899524949
-
Loss of HNF6 expression correlates with human pancreatic cancer progression
-
Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant NB, Maitra A, Means AL and Gannon MA: Loss of HNF6 expression correlates with human pancreatic cancer progression. Lab Invest 94: 517-527, 2014.
-
(2014)
Lab Invest
, vol.94
, pp. 517-527
-
-
Pekala, K.R.1
Ma, X.2
Kropp, P.A.3
Petersen, C.P.4
Hudgens, C.W.5
Chung, C.H.6
Shi, C.7
Merchant, N.B.8
Maitra, A.9
Means, A.L.10
Gannon, M.A.11
-
3
-
-
0037260139
-
Cancer statistics, 2003
-
Jemal A, Murray T, Samuels A, Ghafoor A, Ward E and Thun MJ: Cancer statistics, 2003. CA Cancer J Clin 53: 5-26, 2003.
-
(2003)
CA Cancer J Clin
, vol.53
, pp. 5-26
-
-
Jemal, A.1
Murray, T.2
Samuels, A.3
Ghafoor, A.4
Ward, E.5
Thun, M.J.6
-
4
-
-
84911419076
-
Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
-
Wang Y, Ma W and Zheng W: Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention. Mol Clin Oncol 1: 215-219, 2013.
-
(2013)
Mol Clin Oncol
, vol.1
, pp. 215-219
-
-
Wang, Y.1
Ma, W.2
Zheng, W.3
-
5
-
-
84878878719
-
Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells
-
Mehta R, Katta H, Alimirah F, Patel R, Murillo G, Peng X, Muzzio M and Mehta RG: Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells. PLoS One 8: e65113, 2013.
-
(2013)
Plos One
, vol.8
-
-
Mehta, R.1
Katta, H.2
Alimirah, F.3
Patel, R.4
Murillo, G.5
Peng, X.6
Muzzio, M.7
Mehta, R.G.8
-
6
-
-
77957336029
-
Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer
-
Lee H, Lee JH, Jung KH and Hong SS: Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer. Oncol Rep 24: 957-963, 2010.
-
(2010)
Oncol Rep
, vol.24
, pp. 957-963
-
-
Lee, H.1
Lee, J.H.2
Jung, K.H.3
Hong, S.S.4
-
7
-
-
78049503100
-
Deguelin - An inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model
-
Hu J, Ye H, Fu A, Chen X, Wang Y, Chen X, Ye X, Xiao W, Duan X, Wei Y and Chen L: Deguelin - an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model. Int J Cancer 127: 2455-2466, 2010.
-
(2010)
Int J Cancer
, vol.127
, pp. 2455-2466
-
-
Hu, J.1
Ye, H.2
Fu, A.3
Chen, X.4
Wang, Y.5
Chen, X.6
Ye, X.7
Xiao, W.8
Duan, X.9
Wei, Y.10
Chen, L.11
-
8
-
-
84890426191
-
Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
-
Mehta RR, Katta H, Kalra A, Patel R, Gupta A, Alimirah F, Murillo G, Peng X, Unni A, Muzzio M and Mehta RG: Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells. Clin Exp Metastasis 30: 855-866, 2013.
-
(2013)
Clin Exp Metastasis
, vol.30
, pp. 855-866
-
-
Mehta, R.R.1
Katta, H.2
Kalra, A.3
Patel, R.4
Gupta, A.5
Alimirah, F.6
Murillo, G.7
Peng, X.8
Unni, A.9
Muzzio, M.10
Mehta, R.G.11
-
9
-
-
8444228878
-
An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
-
Adolphe C, Narang M, Ellis T, Wicking C, Kaur P and Wainwright B: An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 131: 5009-5019, 2004.
-
(2004)
Development
, vol.131
, pp. 5009-5019
-
-
Adolphe, C.1
Narang, M.2
Ellis, T.3
Wicking, C.4
Kaur, P.5
Wainwright, B.6
-
10
-
-
0034920373
-
Comparative biological responses to human Sonic, Indian and Desert hedgehog
-
Pathi S, Pagan-Westphal S, Baker DP, Garber EA, Rayhorn P, Bumcrot D, Tabin CJ, Blake Pepinsky R and Williams KP: Comparative biological responses to human Sonic, Indian and Desert hedgehog. Mech Dev 106: 107-117, 2001.
-
(2001)
Mech Dev
, vol.106
, pp. 107-117
-
-
Pathi, S.1
Pagan-Westphal, S.2
Baker, D.P.3
Garber, E.A.4
Rayhorn, P.5
Bumcrot, D.6
Tabin, C.J.7
Blake Pepinsky, R.8
Williams, K.P.9
-
11
-
-
0035958941
-
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node
-
Zhang XM, Ramalho-Santos M and McMahon AP: Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell 105: 781-792, 2001.
-
(2001)
Cell
, vol.105
, pp. 781-792
-
-
Zhang, X.M.1
Ramalho-Santos, M.2
McMahon, A.P.3
-
12
-
-
0030297553
-
Dual roles for patched in sequestering and transducing Hedgehog
-
Chen Y and Struhl G: Dual roles for patched in sequestering and transducing Hedgehog. Cell 87: 553-563, 1996.
-
(1996)
Cell
, vol.87
, pp. 553-563
-
-
Chen, Y.1
Struhl, G.2
-
13
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW and McMahon AP: Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15: 3059-3087, 2001.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
14
-
-
0002452569
-
Developmental roles and clinical significance of hedgehog signaling
-
McMahon AP, Ingham PW and Tabin CJ: Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 53: 1-114, 2003.
-
(2003)
Curr Top Dev Biol
, vol.53
, pp. 1-114
-
-
McMahon, A.P.1
Ingham, P.W.2
Tabin, C.J.3
-
15
-
-
0031683165
-
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
-
Motoyama J, Liu J, Mo R, Ding Q, Post M and Hui CC: Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 20: 54-57, 1998.
-
(1998)
Nat Genet
, vol.20
, pp. 54-57
-
-
Motoyama, J.1
Liu, J.2
Mo, R.3
Ding, Q.4
Post, M.5
Hui, C.C.6
-
16
-
-
0031989439
-
Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog
-
Motoyama J, Takabatake T, Takeshima K and Hui C: Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat Genet 18: 104-106, 1998.
-
(1998)
Nat Genet
, vol.18
, pp. 104-106
-
-
Motoyama, J.1
Takabatake, T.2
Takeshima, K.3
Hui, C.4
-
17
-
-
0032898184
-
Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32
-
Smyth I, Narang MA, Evans T, Heimann C, Nakamura Y, Chenevix-Trench G, Pietsch T, Wicking C and Wainwright BJ: Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. Hum Mol Genet 8: 291-297, 1999.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 291-297
-
-
Smyth, I.1
Narang, M.A.2
Evans, T.3
Heimann, C.4
Nakamura, Y.5
Chenevix-Trench, G.6
Pietsch, T.7
Wicking, C.8
Wainwright, B.J.9
-
18
-
-
0011102935
-
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
-
Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, et al: The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-134, 1996.
-
(1996)
Nature
, vol.384
, pp. 129-134
-
-
Stone, D.M.1
Hynes, M.2
Armanini, M.3
Swanson, T.A.4
Gu, Q.5
Johnson, R.L.6
Scott, M.P.7
Pennica, D.8
Goddard, A.9
Phillips, H.10
-
19
-
-
31744450041
-
Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
-
Barnfield PC, Zhang X, Thanabalasingham V, Yoshida M and Hui CC: Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73: 397-405, 2005.
-
(2005)
Differentiation
, vol.73
, pp. 397-405
-
-
Barnfield, P.C.1
Zhang, X.2
Thanabalasingham, V.3
Yoshida, M.4
Hui, C.C.5
-
20
-
-
0033789068
-
Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
-
Méthot N and Basler K: Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 127: 4001-4010, 2000.
-
(2000)
Development
, vol.127
, pp. 4001-4010
-
-
Méthot, N.1
Basler, K.2
-
21
-
-
84895538497
-
Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer
-
Matsushita S, Onishi H, Nakano K, Nagamatsu I, Imaizumi A, Hattori M, Oda Y, Tanaka M and Katano M: Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer. Cancer Sci 105: 272-280, 2014.
-
(2014)
Cancer Sci
, vol.105
, pp. 272-280
-
-
Matsushita, S.1
Onishi, H.2
Nakano, K.3
Nagamatsu, I.4
Imaizumi, A.5
Hattori, M.6
Oda, Y.7
Tanaka, M.8
Katano, M.9
-
22
-
-
0141757365
-
Matrix metalloproteinases and tumor progression
-
Freije JM, Balbin M, Pendás AM, Sánchez LM, Puente XS and López-Otín C: Matrix metalloproteinases and tumor progression. Adv Exp Med Biol 532: 91-107, 2003.
-
(2003)
Adv Exp Med Biol
, vol.532
, pp. 91-107
-
-
Freije, J.M.1
Balbin, M.2
Pendás, A.M.3
Sánchez, L.M.4
Puente, X.S.5
López-Otín, C.6
-
24
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM and Beachy PA: Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431: 707-712, 2004.
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
Dhara, S.4
Gardner, D.5
Maitra, A.6
Isaacs, J.T.7
Berman, D.M.8
Beachy, P.A.9
-
25
-
-
58949100355
-
Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
-
Liao X, Siu MK, Au CW, Wong ES, Chan HY, Ip PP, Ngan HY and Cheung AN: Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 30: 131-140, 2009.
-
(2009)
Carcinogenesis
, vol.30
, pp. 131-140
-
-
Liao, X.1
Siu, M.K.2
Au, C.W.3
Wong, E.S.4
Chan, H.Y.5
Ip, P.P.6
Ngan, H.Y.7
Cheung, A.N.8
-
26
-
-
33846060232
-
Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma
-
Mori Y, Okumura T, Tsunoda S, Sakai Y and Shimada Y: Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology 70: 378-389, 2006.
-
(2006)
Oncology
, vol.70
, pp. 378-389
-
-
Mori, Y.1
Okumura, T.2
Tsunoda, S.3
Sakai, Y.4
Shimada, Y.5
-
27
-
-
40949137792
-
Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway
-
Yoo YA, Kang MH, Kim JS and Oh SC: Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway. Carcinogenesis 29: 480-490, 2008.
-
(2008)
Carcinogenesis
, vol.29
, pp. 480-490
-
-
Yoo, Y.A.1
Kang, M.H.2
Kim, J.S.3
Oh, S.C.4
-
28
-
-
84871805095
-
Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
-
Li SH, Fu J, Watkins DN, Srivastava RK and Shankar S: Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. Mol Cell Biochem 373: 217-227, 2013.
-
(2013)
Mol Cell Biochem
, vol.373
, pp. 217-227
-
-
Li, S.H.1
Fu, J.2
Watkins, D.N.3
Srivastava, R.K.4
Shankar, S.5
-
29
-
-
84867018979
-
Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal
-
Rodova M, Fu J, Watkins DN, Srivastava RK and Shankar S: Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. PLoS One 7: e46083, 2012.
-
(2012)
Plos One
, vol.7
-
-
Rodova, M.1
Fu, J.2
Watkins, D.N.3
Srivastava, R.K.4
Shankar, S.5
-
30
-
-
84881481410
-
Matrix metalloproteinases in cancer: Their value as diagnostic and prognostic markers and therapeutic targets
-
Hadler-Olsen E, Winberg JO and Uhlin-Hansen L: Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumour Biol 34: 2041-2051, 2013.
-
(2013)
Tumour Biol
, vol.34
, pp. 2041-2051
-
-
Hadler-Olsen, E.1
Winberg, J.O.2
Uhlin-Hansen, L.3
-
31
-
-
0025611427
-
Type IV collagenases in tumor invasion and metastasis
-
Stetler-Stevenson WG: Type IV collagenases in tumor invasion and metastasis. Cancer Metastasis Rev 9: 289-303, 1990.
-
(1990)
Cancer Metastasis Rev
, vol.9
, pp. 289-303
-
-
Stetler-Stevenson, W.G.1
-
32
-
-
84903466928
-
Down-regulation of Gli-1 inhibits hepatocellular carcinoma cell migration and invasion
-
Chen JS, Li HS, Huang JQ, Zhang LJ, Chen XL, Wang Q, Lei J, Feng JT, Liu Q and Huang XH: Down-regulation of Gli-1 inhibits hepatocellular carcinoma cell migration and invasion. Mol Cell Biochem 393: 283-291, 2014.
-
(2014)
Mol Cell Biochem
, vol.393
, pp. 283-291
-
-
Chen, J.S.1
Li, H.S.2
Huang, J.Q.3
Zhang, L.J.4
Chen, X.L.5
Wang, Q.6
Lei, J.7
Feng, J.T.8
Liu, Q.9
Huang, X.H.10
-
33
-
-
84901001371
-
The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs
-
Chen M, Qian Y, Dai J and Chu R: The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs. PLoS One 9: e96952, 2014.
-
(2014)
Plos One
, vol.9
-
-
Chen, M.1
Qian, Y.2
Dai, J.3
Chu, R.4
-
34
-
-
84902037962
-
Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression
-
Fan HX, Wang S, Zhao H, Liu N, Chen D, Sun M and Zheng JH: Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression. Med Oncol 31: 41, 2014.
-
(2014)
Med Oncol
, vol.31
, pp. 41
-
-
Fan, H.X.1
Wang, S.2
Zhao, H.3
Liu, N.4
Chen, D.5
Sun, M.6
Zheng, J.H.7
|