메뉴 건너뛰기




Volumn 12, Issue 4, 2016, Pages 2761-2765

Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway

Author keywords

Deguelin; Hedgehog signaling pathway; Pancreatic cancer

Indexed keywords

DEGUELIN; GELATINASE A; GELATINASE B;

EID: 84983391566     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2016.4928     Document Type: Article
Times cited : (25)

References (34)
  • 4
    • 84911419076 scopus 로고    scopus 로고
    • Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
    • Wang Y, Ma W and Zheng W: Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention. Mol Clin Oncol 1: 215-219, 2013.
    • (2013) Mol Clin Oncol , vol.1 , pp. 215-219
    • Wang, Y.1    Ma, W.2    Zheng, W.3
  • 6
    • 77957336029 scopus 로고    scopus 로고
    • Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer
    • Lee H, Lee JH, Jung KH and Hong SS: Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer. Oncol Rep 24: 957-963, 2010.
    • (2010) Oncol Rep , vol.24 , pp. 957-963
    • Lee, H.1    Lee, J.H.2    Jung, K.H.3    Hong, S.S.4
  • 7
    • 78049503100 scopus 로고    scopus 로고
    • Deguelin - An inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model
    • Hu J, Ye H, Fu A, Chen X, Wang Y, Chen X, Ye X, Xiao W, Duan X, Wei Y and Chen L: Deguelin - an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model. Int J Cancer 127: 2455-2466, 2010.
    • (2010) Int J Cancer , vol.127 , pp. 2455-2466
    • Hu, J.1    Ye, H.2    Fu, A.3    Chen, X.4    Wang, Y.5    Chen, X.6    Ye, X.7    Xiao, W.8    Duan, X.9    Wei, Y.10    Chen, L.11
  • 9
    • 8444228878 scopus 로고    scopus 로고
    • An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
    • Adolphe C, Narang M, Ellis T, Wicking C, Kaur P and Wainwright B: An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 131: 5009-5019, 2004.
    • (2004) Development , vol.131 , pp. 5009-5019
    • Adolphe, C.1    Narang, M.2    Ellis, T.3    Wicking, C.4    Kaur, P.5    Wainwright, B.6
  • 11
    • 0035958941 scopus 로고    scopus 로고
    • Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node
    • Zhang XM, Ramalho-Santos M and McMahon AP: Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell 105: 781-792, 2001.
    • (2001) Cell , vol.105 , pp. 781-792
    • Zhang, X.M.1    Ramalho-Santos, M.2    McMahon, A.P.3
  • 12
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y and Struhl G: Dual roles for patched in sequestering and transducing Hedgehog. Cell 87: 553-563, 1996.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 13
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW and McMahon AP: Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15: 3059-3087, 2001.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 14
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • McMahon AP, Ingham PW and Tabin CJ: Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 53: 1-114, 2003.
    • (2003) Curr Top Dev Biol , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 15
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • Motoyama J, Liu J, Mo R, Ding Q, Post M and Hui CC: Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 20: 54-57, 1998.
    • (1998) Nat Genet , vol.20 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3    Ding, Q.4    Post, M.5    Hui, C.C.6
  • 16
    • 0031989439 scopus 로고    scopus 로고
    • Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog
    • Motoyama J, Takabatake T, Takeshima K and Hui C: Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat Genet 18: 104-106, 1998.
    • (1998) Nat Genet , vol.18 , pp. 104-106
    • Motoyama, J.1    Takabatake, T.2    Takeshima, K.3    Hui, C.4
  • 17
    • 0032898184 scopus 로고    scopus 로고
    • Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32
    • Smyth I, Narang MA, Evans T, Heimann C, Nakamura Y, Chenevix-Trench G, Pietsch T, Wicking C and Wainwright BJ: Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. Hum Mol Genet 8: 291-297, 1999.
    • (1999) Hum Mol Genet , vol.8 , pp. 291-297
    • Smyth, I.1    Narang, M.A.2    Evans, T.3    Heimann, C.4    Nakamura, Y.5    Chenevix-Trench, G.6    Pietsch, T.7    Wicking, C.8    Wainwright, B.J.9
  • 19
    • 31744450041 scopus 로고    scopus 로고
    • Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    • Barnfield PC, Zhang X, Thanabalasingham V, Yoshida M and Hui CC: Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73: 397-405, 2005.
    • (2005) Differentiation , vol.73 , pp. 397-405
    • Barnfield, P.C.1    Zhang, X.2    Thanabalasingham, V.3    Yoshida, M.4    Hui, C.C.5
  • 20
    • 0033789068 scopus 로고    scopus 로고
    • Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
    • Méthot N and Basler K: Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 127: 4001-4010, 2000.
    • (2000) Development , vol.127 , pp. 4001-4010
    • Méthot, N.1    Basler, K.2
  • 23
    • 15244342010 scopus 로고    scopus 로고
    • Matrix metalloproteinases as therapeutic targets in cancer
    • Vihinen P, Ala-Aho R and Kähäri VM: Matrix metalloproteinases as therapeutic targets in cancer. Curr Cancer Drug Targets 5: 203-220, 2005.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 203-220
    • Vihinen, P.1    Ala-Aho, R.2    Kähäri, V.M.3
  • 25
    • 58949100355 scopus 로고    scopus 로고
    • Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
    • Liao X, Siu MK, Au CW, Wong ES, Chan HY, Ip PP, Ngan HY and Cheung AN: Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 30: 131-140, 2009.
    • (2009) Carcinogenesis , vol.30 , pp. 131-140
    • Liao, X.1    Siu, M.K.2    Au, C.W.3    Wong, E.S.4    Chan, H.Y.5    Ip, P.P.6    Ngan, H.Y.7    Cheung, A.N.8
  • 26
    • 33846060232 scopus 로고    scopus 로고
    • Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma
    • Mori Y, Okumura T, Tsunoda S, Sakai Y and Shimada Y: Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology 70: 378-389, 2006.
    • (2006) Oncology , vol.70 , pp. 378-389
    • Mori, Y.1    Okumura, T.2    Tsunoda, S.3    Sakai, Y.4    Shimada, Y.5
  • 27
    • 40949137792 scopus 로고    scopus 로고
    • Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway
    • Yoo YA, Kang MH, Kim JS and Oh SC: Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway. Carcinogenesis 29: 480-490, 2008.
    • (2008) Carcinogenesis , vol.29 , pp. 480-490
    • Yoo, Y.A.1    Kang, M.H.2    Kim, J.S.3    Oh, S.C.4
  • 28
    • 84871805095 scopus 로고    scopus 로고
    • Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
    • Li SH, Fu J, Watkins DN, Srivastava RK and Shankar S: Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. Mol Cell Biochem 373: 217-227, 2013.
    • (2013) Mol Cell Biochem , vol.373 , pp. 217-227
    • Li, S.H.1    Fu, J.2    Watkins, D.N.3    Srivastava, R.K.4    Shankar, S.5
  • 29
    • 84867018979 scopus 로고    scopus 로고
    • Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal
    • Rodova M, Fu J, Watkins DN, Srivastava RK and Shankar S: Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. PLoS One 7: e46083, 2012.
    • (2012) Plos One , vol.7
    • Rodova, M.1    Fu, J.2    Watkins, D.N.3    Srivastava, R.K.4    Shankar, S.5
  • 30
    • 84881481410 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: Their value as diagnostic and prognostic markers and therapeutic targets
    • Hadler-Olsen E, Winberg JO and Uhlin-Hansen L: Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumour Biol 34: 2041-2051, 2013.
    • (2013) Tumour Biol , vol.34 , pp. 2041-2051
    • Hadler-Olsen, E.1    Winberg, J.O.2    Uhlin-Hansen, L.3
  • 31
    • 0025611427 scopus 로고
    • Type IV collagenases in tumor invasion and metastasis
    • Stetler-Stevenson WG: Type IV collagenases in tumor invasion and metastasis. Cancer Metastasis Rev 9: 289-303, 1990.
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 289-303
    • Stetler-Stevenson, W.G.1
  • 33
    • 84901001371 scopus 로고    scopus 로고
    • The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs
    • Chen M, Qian Y, Dai J and Chu R: The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs. PLoS One 9: e96952, 2014.
    • (2014) Plos One , vol.9
    • Chen, M.1    Qian, Y.2    Dai, J.3    Chu, R.4
  • 34
    • 84902037962 scopus 로고    scopus 로고
    • Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression
    • Fan HX, Wang S, Zhao H, Liu N, Chen D, Sun M and Zheng JH: Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression. Med Oncol 31: 41, 2014.
    • (2014) Med Oncol , vol.31 , pp. 41
    • Fan, H.X.1    Wang, S.2    Zhao, H.3    Liu, N.4    Chen, D.5    Sun, M.6    Zheng, J.H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.