Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer

Cancer Science

Volumn 105, Issue 3, 2014, Pages 272-280

  Matsushita, Shojiro ^a   Onishi, Hideya ^a   Nakano, Kenji ^b   Nagamatsu, Iori ^a   Imaizumi, Akira ^c   Hattori, Masami ^a   Oda, Yoshinao ^a   Tanaka, Masao ^a   Katano, Mitsuo ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c Shukoukai Inc   (Japan)

Author keywords

Epithelial mesenchymal transition; Gallbladder cancer; Hedgehog; Matrix metalloproteinase; Smo protein

Indexed keywords

GELATINASE A; GELATINASE B; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ADULT; AGED; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER PATIENT; CANCER STAGING; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GALLBLADDER CANCER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MIDDLE AGED; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TUMOR MODEL; TUMOR VOLUME; TUMOR XENOGRAFT; VERY ELDERLY; WESTERN BLOTTING;

EPITHELIAL-MESENCHYMAL TRANSITION; GALLBLADDER CANCER; HEDGEHOG; MATRIX METALLOPROTEINASE; SMO PROTEIN;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GALLBLADDER; GALLBLADDER NEOPLASMS; GENE KNOCKDOWN TECHNIQUES; HEDGEHOG PROTEINS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VERATRUM ALKALOIDS;

EID: 84895538497     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12354     Document Type: Article

References (32)

1. Misra S, Chaturvedi A, Misra NC, Sharma ID. Carcinoma of the gallbladder. Lancet Oncol 2003; 4: 167-76.
2. Glauser PM, Strub D, Käser SA, Mattiello D, Rieben F, Maurer CA. Incidence, management, and outcome of incidental gallbladder carcinoma: analysis of the database of the Swiss association of laparoscopic and thoracoscopic surgery. Surg Endosc 2010; 24: 2281-6.
3. Gourgiotis S, Kocher HM, Solaini L, Yarollahi A, Tsiambas E, Salemis NS. Gallbladder cancer. Am J Surg 2008; 196: 252-64.
4. Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15: 3059-87.
5. Onishi H, Kai M, Odate S et al. Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. Cancer Sci 2011; 102: 1144-50.
6. Iwasaki H, Nakano K, Shinkai K et al. Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes. Cancer Sci 2013; 104: 328-36.
7. Yanai K, Nagai S, Wada J et al. Hedgehog signaling pathway is a possible therapeutic target for gastric cancer. J Surg Oncol 2007; 95(1): 55-62.
8. Kubo M, Nakamura M, Tasaki A et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004; 64: 6071-4.
9. Dierks C, Beigi R, Guo GR et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008; 14: 238-49.
10. Peacock CD, Wang Q, Gesell GS et al. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A 2007; 104: 4048-53.
11. Zhao C, Chen A, Jamieson CH et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009; 458: 776-9.
12. Clement V, Sanchez P, de Tribolet N, Radovanovic I. Ruiz i Altaba A. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007; 17: 165-72.
13. A phase III study of oral LDE225 versus temozolomide in patients with hedgehog pathway activated relapsed medulloblastoma. Available from: http://clinicaltrials.gov.show/NCT01708174.
14. Jimeno A, Weiss GJ, Miller WH et al. Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors. Clin Cancer Res 2013; 19: 2766-74.
15. Poggi L, Kolesar JM. Vismodegib for the treatment of basal cell skin cancer. Am J Health Syst Pharm 2013; 70: 1033-8.
16. Sasaki S, Kuniyasu H, Luo Y et al. Significance of epithelial growth factor in the epithelial-mesenchymal transition of human gallbladder cancer cells. Cancer Sci 2012; 103: 1165-71.
17. Sato J, Kimura T, Saito T et al. Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma. J Hepatobiliary Pancreat Sci 2011; 18: 700-11.
18. Nagai S, Nakamura M, Yanai K et al. Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation. Cancer Sci 2008; 99: 1377-84.
19. Kameda C, Tanaka H, Yamasaki A et al. The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer. Anticancer Res 2009; 29: 871-9.
20. Akiyoshi T, Nakamura M, Koga K et al. Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. Gut 2006; 55: 991-9.
21. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-90.
22. Von Hoff DD, LoRusso PM, Rudin CM et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009; 361: 1164-72.
23. Rudin CM, Hann CL, Laterra J et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009; 361: 1173-8.
24. Li J, Wu T, Lu J et al. Immunohistochemical evidence of the prognostic value of hedgehog pathway components in primary gallbladder carcinoma. Surg Today 2012; 42: 770-5.
25. Kamat AA, Fletcher M, Gruman LM et al. The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer. Clin Cancer Res 2006; 12: 1707-14.
26. Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol 2000; 18: 1135-49.
27. Lei J, Ma J, Ma Q et al. Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner. Mol Cancer 2013; 12: 66.
28. El Khatib M, Kalnytska A, Palagani V et al. Inhibition of hedgehog signaling attenuates carcinogenesis in vitro and increases necrosis of cholangiocellular carcinoma. Hepatology 2013; 57: 1035-45.
29. Ota H, Aoyagi K, Fukaya M et al. Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. Br J Cancer 2009; 100: 389-98.
30. Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002; 3: 155-66.
31. Kwon MJ, Kwon JH, Nam ES et al. TWIST1 promoter methylation is associated with prognosis in tonsillar squamous cell carcinoma. Hum Pathol 2013; 44: 1722-9.
32. Ma L, Young J, Prabhala H et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010; 12: 247-56.