High rate of sickle cell anaemia in Sub-Saharan Africa underlines the need to screen all children with severe anaemia for the disease

Acta Paediatrica, International Journal of Paediatrics

Volumn 104, Issue 12, 2015, Pages 1269-1273

  Kadima, Bertin Tshimanga ^a   Gini Ehungu, Jean Lambert ^a   Ngiyulu, René Makwala ^a   Ekulu, Pépé Mfutu ^a   Aloni, Michel Ntetani ^a  

^a University Hospital of Kinshasa University of Kinshasa   (Congo)

Author keywords

Democratic Republic of Congo; Screening; Severe anaemia; Sickle cell anaemia; Sub Saharan Africa

Indexed keywords

HEMOGLOBIN BETA CHAIN; HEMOGLOBIN S;

AFRICA SOUTH OF THE SAHARA; ANEMIA; ARTICLE; BLOOD TRANSFUSION; CHILD; CROSS-SECTIONAL STUDY; ELECTROPHORESIS; FEMALE; HAND FOOT SYNDROME; HEPATOMEGALY; HETEROZYGOTE; HUMAN; IRON DEFICIENCY ANEMIA; JAUNDICE; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY DISTRESS; SICKLE CELL ANEMIA; SPLENOMEGALY; ANEMIA, SICKLE CELL; COMPLICATION; INFANT; MASS SCREENING; PRESCHOOL CHILD; PREVALENCE;

AFRICA SOUTH OF THE SAHARA; ANEMIA; ANEMIA, SICKLE CELL; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INFANT; MALE; MASS SCREENING; PREVALENCE; PROSPECTIVE STUDIES;

EID: 84983203471     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/apa.13040     Document Type: Article

References (28)

1. Piel FB, Hay SI, Gupta S, Weatherall DJ, Williams TN,. Global burden of sickle cell anemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions. PLoS Med 2013; 10: e1001484.
2. Grosse SD, Odame I, Atrash HK, Amendah DD, Piel FB, Williams TN,. Sickle cell disease in Africa: a neglected cause of early childhood mortality. Am J Prev Med 2011; 41: S398-405.
3. Serjeant GR,. Mortality from sickle cell disease in Africa. BMJ 2005; 330: 432-3.
4. Tshilolo L, Aissi LM, Lukusa D, Kinsiama C, Wembonyama S, Gulbis B, et al., Neonatal screening for sickle cell anemia in the Democratic Republic of the Congo: experience from a pioneer project on 31 204 newborns. J Clin Pathol 2009; 62: 35-8.
5. Agasa B, Bosunga K, Opara A, Tshilumba K, Dupont E, Vertongen F, et al., Prevalence of sickle cell disease in a northeastern region of the Democratic Republic of Congo: what impact on transfusion policy? Transfus Med 2010; 20: 62-5.
6. Tshilolo L, Summa V, Gregorj C, Kinsiama C, Bazeboso JA, Avvisati G, et al., Foetal haemoglobin, erythrocytes containing foetal haemoglobin, and hematological features in congolese patients with sickle cell anaemia. Anemia 2012; 2012: 105349.
7. Wembonyama S, Mpaka S, Tshilolo L,. Medicine and health in the Democratic Republic of Congo: from Independence to the Third Republic. Med Trop (Mars) 2007; 67: 447-57.
8. De Montalembert M, Tshilolo L,. Is therapeutic progress in the management of sickle cell disease applicable in sub-Saharan Africa? Med Trop (Mars) 2007; 67: 612-6.
9. Aloni MN, Nkee L,. Challenge of managing sickle cell disease in a pediatric population living in kinshasa, Democratic Republic of Congo: a sickle cell center experience. Hemoglobin 2014; 38: 196-200.
10. Aloni MN, Tshimanga BK, Ekulu PM, Ehungu JL, Ngiyulu RM,. Malaria, clinical features and acute crisis in children suffering from sickle cell disease in resource-limited settings: a retrospective description of 90 cases. Pathog Glob Health 2013; 107: 198-201.
11. Tshilolo LM, Mukendi RK, Wembonyama SO,. Blood transfusion rate in Congolese patients with sickle cell anemia. Indian J Pediatr 2007; 74: 735-8.
12. Tshilolo L, Mukendi R, Girot R,. Sickle cell anemia in the south of Zaire. Study of two series of 251 and 340 patients followed-up 1988-1992]. Arch Pediatr 1996; 3: 104-11.
13. Batina AS, Dupont E, Kayembe T, Molima P, Malengela R, Kabemba S, et al., Multiple transfusions for sickle cell disease in the Democratic Republic of Congo: the importance of the hepatitis C virus. Transfus Clin Biol 2010; 17: 254-9.
14. Izzia KW, Lepira B, Kayembe K, Odio W,. Acquired immunodeficiency syndrome and homozygote sickle cell anemia. Apropos of a Zairian case. Ann Soc Belg Med Trop 1984; 64: 391-6.
15. World Health Organization. Management of the Child with a Serious Infection or Severe Malnutrition: Guidelines for Care at the First-referral Level in Developing Countries. Geneva: World Health Organisation, 2000.
16. Mueller Y, Bastard M, Ehounou G, Itama J, Quéré M, de la Tour R, et al., Effectiveness of blood transfusions and risk factors for mortality in children aged from 1 month to 4 years at the Bon Marché Hospital, Bunia, Democratic Republic of the Congo. Trop Med Int Health 2012; 17: 1457-64.
17. Kuvibidila S, Yu L, Ode D, Mbele V, Warrier RJ,. An epidemiological study of hemoglobin levels and prevalence of anemia in young children from Bas-Zaire. Ann Soc Belg Med Trop 1993; 73: 227-34.
18. Kunuanunua TS, Nsibu CN, Gini-Ehungu JL, Bodi JM, Ekulu PM, Situakibanza H, et al., Acute renal failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo. Nephrol Ther 2013; 9: 160-5.
19. Rees DC, Williams TN, Gladwin MT,. Sickle-cell disease. Lancet 2010; 376: 2018-31.
20. Makani J, Cox SE, Soka D, Komba AN, Oruo J, Mwamtemi H, et al., Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania. PLoS ONE 2011; 6: e14699.
21. Thorne CJ, Roberts LM, Edwards DR, Haque MS, Cumbassa A, Last AR,. Anaemia and malnutrition in children aged 0-59 months on the Bijagõs Archipelago, Guinea-Bissau, West Africa: a cross-sectional, population-based study. Paediatr Int Child Health 2013; 33: 151-60.
22. Owusu-Agyei S, Fryauff DJ, Chandramohan D, Koram KA, Binka FN, Nkrumah FK, et al., Characteristics of severe anemia and its association with malaria in young children of the Kassena-Nankana District of northern Ghana. Am J Trop Med Hyg 2002; 67: 371-7.
23. Akinyanju OO,. A profile of sickle cell disease in Nigeria. Ann N Y Acad Sci 1989; 565: 126-36.
24. Chippaux JP, Massougbodji A, Boulard JC, Akogbeto M,. Morbidity and severity of malaria attacks in carriers of sickle-cell trait. Rev Epidemiol Sante Publique 1992; 40: 240-5.
25. Albiti AH, Nsiah K,. Comparative haematological parameters of HbAA and HbAS genotype children infected with Plasmodium falciparum malaria in Yemen. Hematology 2014; 19: 169-74.
26. Ndugwa C, Higgs D, Fisher C, Hambleton I, Mason K, Serjeant BE, et al., Homozygous sickle cell disease in Uganda and Jamaica a comparison of Bantu and Benin haplotypes. West Indian Med J 2012; 61: 684-91.
27. Ambe JP, Mava Y, Chama R, Farouq G, Machoko Y,. Clinical features of sickle cell anemia in northern Nigerian children. West Afr J Med 2012; 31: 81-5.
28. de Montalembert M, Guilloud-Bataille M, Feingold J, Girot R,. Epidemiological and clinical study of sickle cell disease in France, French Guiana and Algeria. Eur J Haematol 1993; 51: 136-40.