Neonatal screening for sickle cell anaemia in the Democratic Republic of the Congo: Experience from a pioneer project on 31 204 newborns

Journal of Clinical Pathology

Volumn 62, Issue 1, 2009, Pages 35-38

  Tshilolo, L ^a,d,f   Aissi, L M ^b   Lukusa, D ^b   Kinsiama, C ^c   Wembonyama, S ^d   Gulbis, B ^e   Vertongen, F ^e  

^a Centre Hospitalier Monkole (CHM)   (Congo)

^b Centre de Formation et d'Appui Sanitaire (CEFA)   (Congo)

^c CHM   (Congo)

^d UNIVERSITÉ DE LUBUMBASHI   (Congo)

^e ERASME HOSPITAL   (Belgium)

^f Centre Hospitalier Monkole   (Congo)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONGO; GENE FREQUENCY; HOMOZYGOSITY; HOMOZYGOTE; HUMAN; ISOELECTRIC FOCUSING; MAJOR CLINICAL STUDY; MALARIA; MARRIAGE; NEWBORN; NEWBORN SCREENING; PREVALENCE; PRIORITY JOURNAL; SCREENING; SICKLE CELL ANEMIA; SICKLE CELL TRAIT;

ANEMIA, SICKLE CELL; CONGO; FEMALE; HUMANS; INFANT, NEWBORN; MALE; NEONATAL SCREENING; PREVALENCE; PROGRAM EVALUATION;

EID: 58349117668     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2008.058958     Document Type: Article

References (16)

1. Weatherall DJ, Akinyanju O, Fucharoen S, et al. Inherited disorders of hemoglobin. In: Disease control priorities in developing countries. In: Jamison DT, Bobadilla J-S, Mosley WH, Measham AR, eds. New York: Oxford University Press and the World Bank, 2006:663-80.
2. Wembonyama S, Mpaka S, Tshilolo L. Médecine et santé en République Démocratique du Congo: de I'indépendance à la 3è république. Med Trop 2007;67:447-57.
3. Saint Moulin L de. Panorama de I'histoire contemporaine. Kinshasa: Ed. de la Commission Episcopale de I'Education Chrétienne, 1983.
4. World Health Organization. La drépanocytose dans la région africaine: situation actuelle et perspectives. Report 0MS/AFR/RC56/17. Geneva: World Health Organization, 2006.
5. Angastiniotis M, Modell B, Englezos P, et al. Prevention and control haemoglobinopathies. Bull WHO 1995;73:375-86.
6. Vandepitte J, Stijns J. Les hémoglobinoses au Congo (Léopoldville) et au Rwanda-Burundi. Ann Soc beige Med trop 1963;43:271.
7. Gatti F, Van Ros G, Vandepitte J. Hémoglobines anormales à la maternité de Kinshasa. Une nouvelle famille congolaise avec hémoglobine E. Ann Soc beige Med trop 1970;50:595-612.
8. Van Baelen H, Vandepitte J, Eeckels R. Observations on sickle cell anaemia and haemoglobin Bart's in Congolese neonates. Ann Soc beige Med trop 1969;49:157-64.
9. Livingstone FB. Frequencies of hemoglobin variants. Thalassemia, the glucose-6-phosphate dehydrogenase deficiency, G6PD variants, and ovalocytosis in human populations. New York: Oxford University Press, 1985.
10. Tshilolo L, Kafando E, Sawadogo M, et al. Neonatal screening and clinical care programme for sickle cell disorders in sub-Saharan Africa: which lessons from pilot studies in Democratic Republic of the Congo and Burkina Faso? Public Health 2008;122:933-41.
11. Tshilolo L, Wembonyama S. Early management of sickle cell anemia in central Africa: is it possible. Asian Pac J Trop Med 2008;1:7-13.
12. Rahimy MC, Gangbo A, Ahouignan G. et al. Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan setting. Blood 2003;102:834-8.
13. Reddy PH, Model B. Reproductive behaviour and natural selction for sickle cell gene in the Baiga Tribe of Central India: The role of social parenting. Ann Hum Genet 1996;60:231-6.
14. Aidoo M, Terlouw DJ, Kolczak MS, et al. Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet 2002;359:1311-2.
15. Diaz-Barrios V. Newborn screening for sickle cell disease and other hemoglobinopathies. New York's experience. Pediatrics 1989;83:872-5.
16. Ohene-Frempong K, Bonney A, Tetteh H, et al. Newborn screening for sickle cell disease in Ghana. 10 years of testing, tracking, and follow-up: European Society for Pediatric Research, Siena, Italy. Pediatr Res 2005;58:401.