Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes

Basic and Clinical Pharmacology and Toxicology

Volumn 118, Issue 2, 2016, Pages 160-167

  Woolbright, Benjamin L ^a   Mcgill, Mitchell R ^a   Yan, Huimin ^a   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CASPASE 3; CASPASE INHIBITOR; GLYCOCHENODEOXYCHOLIC ACID; LACTATE DEHYDROGENASE; STRESS ACTIVATED PROTEIN KINASE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; Z VD FMK; BENZYLOXYCARBONYL-VALYL-ASPARTIC ACID FLUOROMETHYL KETONE; PEPTIDE CHLOROMETHYL KETONE; PROTECTIVE AGENT;

ANIMAL CELL; ARTICLE; CARCINOMA CELL LINE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; ENZYME RELEASE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CARCINOMA; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; APOPTOSIS; CHOLESTASIS; COMPARATIVE STUDY; DRUG EFFECTS; HEP-G2 CELL LINE; METABOLISM;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BILE ACIDS AND SALTS; CHOLESTASIS; GLYCOCHENODEOXYCHOLIC ACID; HEP G2 CELLS; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; PROTECTIVE AGENTS; TAUROCHOLIC ACID;

EID: 84983156601     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12449     Document Type: Article

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