Halogenated phenazines that potently eradicate biofilms, MRSA persister cells in non-biofilm cultures, and mycobacterium tuberculosis

Angewandte Chemie - International Edition

Volumn 54, Issue 49, 2015, Pages 14819-14823

  Garrison, Aaron T ^a   Abouelhassan, Yasmeen ^a   Kallifidas, Dimitris ^a   Bai, Fang ^a   Ukhanova, Maria ^b   Mai, Volker ^b   Jin, Shouguang ^a   Luesch, Hendrik ^a   Huigens, Robert W ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

bacterial biofilms; biofilm eradication; halogenated phenazines; marine antibiotics; medicinal chemistry

Indexed keywords

ANTIBIOTICS; BACTERIA; CELLS; CYTOLOGY; HALOGENATION; MAMMALS;

ANTI-BACTERIAL ACTIVITY; BACTERIAL BIOFILM; BACTERIAL INFECTIONS; HALOGENATED PHENAZINES; MARINE ANTIBIOTIC; MARINE NATURAL PRODUCTS; MEDICINAL CHEMISTRY; MYCOBACTERIUM TUBERCULOSIS;

BIOFILMS;

ANTIINFECTIVE AGENT; PHENAZINE DERIVATIVE;

BIOFILM; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HELA CELL LINE; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TEST; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BIOFILMS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PHENAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84983096118     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201508155     Document Type: Article

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