Membrane Active Small Molecules Show Selective Broad Spectrum Antibacterial Activity with No Detectable Resistance and Eradicate Biofilms

Journal of Medicinal Chemistry

Volumn 58, Issue 14, 2015, Pages 5486-5500

  Hoque, Jiaul ^a   Konai, Mohini M ^a   Gonuguntla, Spandhana ^a   Manjunath, Goutham B ^a   Samaddar, Sandip ^a   Yarlagadda, Venkateswarlu ^a   Haldar, Jayanta ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BIOCIDE; N,N' (BUTANE 1,4 DIETHANAMIDE)BIS[N,N DIMETHYL (N' DODECYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (BUTANE 1,4 DIETHANAMIDE)BIS[N,N DIMETHYL (N' HEXADECYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (BUTANE 1,4 DIETHANAMIDE)BIS[N,N DIMETHYL (N' HEXYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (BUTANE 1,4 DIETHANAMIDE)BIS[N,N DIMETHYL (N' OCTYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (ETHANE 1,2 DIETHANAMIDE)BIS[N,N DIMETHYL (N' DODECYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (ETHANE 1,2 DIETHANAMIDE)BIS[N,N DIMETHYL (N' HEXADECYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (ETHANE 1,2 DIETHANAMIDE)BIS[N,N DIMETHYL (N' HEXYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (ETHANE 1,2 DIETHANAMIDE)BIS[N,N DIMETHYL (N' OCTYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (HEXANE 1,6 DIETHANAMIDE)BIS[N,N DIMETHYL (N' DODECYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (HEXANE 1,6 DIETHANAMIDE)BIS[N,N DIMETHYL (N' HEXADECYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (HEXANE 1,6 DIETHANAMIDE)BIS[N,N DIMETHYL (N' HEXYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (HEXANE 1,6 DIETHANAMIDE)BIS[N,N DIMETHYL (N' OCTYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (PROPANE 1,3 DIETHANAMIDE)BIS[N,N DIMETHYL (N' DODECYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (PROPANE 1,3 DIETHANAMIDE)BIS[N,N DIMETHYL (N' HEXADECYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (PROPANE 1,3 DIETHANAMIDE)BIS[N,N DIMETHYL (N' HEXYLETHANAMIDE)AMMONIUM BROMIDE]; N,N' (PROPANE 1,3 DIETHANAMIDE)BIS[N,N DIMETHYL (N' OCTYLETHANAMIDE)AMMONIUM BROMIDE]; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; MOLECULAR LIBRARY; POTASSIUM;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; BIOFILM; BIOLOGICAL ACTIVITY; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; KLEBSIELLA PNEUMONIAE; MAMMAL CELL; MEMBRANE PERMEABILITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS; WILD TYPE; BACTERIUM; CELL MEMBRANE; CHEMICAL PHENOMENA; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HEK293 CELL LINE; INTRACELLULAR SPACE; KINETICS; MEMBRANE POTENTIAL; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR LIBRARY; PERMEABILITY; PHARMACOLOGY; TOXICITY;

ANTI-BACTERIAL AGENTS; BACTERIA; BIOFILMS; CELL MEMBRANE; DRUG RESISTANCE, BACTERIAL; HEK293 CELLS; HEMOLYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTRACELLULAR SPACE; KINETICS; MEMBRANE POTENTIALS; MICROBIAL SENSITIVITY TESTS; PERMEABILITY; POTASSIUM; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937692301     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00443     Document Type: Article

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