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Volumn 195, Issue 12, 2015, Pages 5816-5826

Tumor-unrelated CD4 T cell help augments CD134 plus CD137 dual costimulation tumor therapy

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CD137 ANTIGEN; EPITOPE; GRANZYME B; TRANSCRIPTION FACTOR FOXP3; CYTOKINE;

EID: 84983094244     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1502032     Document Type: Article
Times cited : (15)

References (58)
  • 1
    • 0031782910 scopus 로고    scopus 로고
    • The role of CD4+ T cell responses in antitumor immunity
    • Pardoll, D. M., and S. L. Topalian. 1998. The role of CD4+ T cell responses in antitumor immunity. Curr. Opin. Immunol. 10: 588-594.
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 588-594
    • Pardoll, D.M.1    Topalian, S.L.2
  • 5
    • 77954723327 scopus 로고    scopus 로고
    • CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells
    • Nesbeth, Y. C., D. G. Martinez, S. Toraya, U. K. Scarlett, J. R. Cubillos-Ruiz, M. R. Rutkowski, and J. R. Conejo-Garcia. 2010. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J. Immunol. 184: 5654-5662.
    • (2010) J. Immunol. , vol.184 , pp. 5654-5662
    • Nesbeth, Y.C.1    Martinez, D.G.2    Toraya, S.3    Scarlett, U.K.4    Cubillos-Ruiz, J.R.5    Rutkowski, M.R.6    Conejo-Garcia, J.R.7
  • 6
  • 8
    • 3543099130 scopus 로고    scopus 로고
    • Helping the CD8(+) T-cell response
    • Bevan, M. J. 2004. Helping the CD8(+) T-cell response. Nat. Rev. Immunol. 4: 595-602.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 595-602
    • Bevan, M.J.1
  • 9
    • 0032473562 scopus 로고    scopus 로고
    • Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
    • Ossendorp, F., E. Mengedé, M. Camps, R. Filius, and C. J. Melief. 1998. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J. Exp. Med. 187: 693-702.
    • (1998) J. Exp. Med. , vol.187 , pp. 693-702
    • Ossendorp, F.1    Mengedé, E.2    Camps, M.3    Filius, R.4    Melief, C.J.5
  • 10
  • 12
    • 78149309084 scopus 로고    scopus 로고
    • Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase
    • Schietinger, A., M. Philip, R. B. Liu, K. Schreiber, and H. Schreiber. 2010. Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase. J. Exp. Med. 207: 2469-2477.
    • (2010) J. Exp. Med. , vol.207 , pp. 2469-2477
    • Schietinger, A.1    Philip, M.2    Liu, R.B.3    Schreiber, K.4    Schreiber, H.5
  • 13
    • 78449290135 scopus 로고    scopus 로고
    • CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes
    • Bos, R., and L. A. Sherman. 2010. CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes. Cancer Res. 70: 8368-8377.
    • (2010) Cancer Res. , vol.70 , pp. 8368-8377
    • Bos, R.1    Sherman, L.A.2
  • 14
    • 0031963994 scopus 로고    scopus 로고
    • Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity
    • Morgan, D. J., H. T. Kreuwel, S. Fleck, H. I. Levitsky, D. M. Pardoll, and L. A. Sherman. 1998. Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity. J. Immunol. 160: 643-651.
    • (1998) J. Immunol. , vol.160 , pp. 643-651
    • Morgan, D.J.1    Kreuwel, H.T.2    Fleck, S.3    Levitsky, H.I.4    Pardoll, D.M.5    Sherman, L.A.6
  • 18
    • 84887991307 scopus 로고    scopus 로고
    • Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma
    • Dudley, M. E., C. A. Gross, R. P. Somerville, Y. Hong, N. P. Schaub, S. F. Rosati, D. E. White, D. Nathan, N. P. Restifo, S. M. Steinberg, et al. 2013. Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma. J. Clin. Oncol. 31: 2152-2159.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 2152-2159
    • Dudley, M.E.1    Gross, C.A.2    Somerville, R.P.3    Hong, Y.4    Schaub, N.P.5    Rosati, S.F.6    White, D.E.7    Nathan, D.8    Restifo, N.P.9    Steinberg, S.M.10
  • 20
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    • Ridge, J. P., F. Di Rosa, and P. Matzinger. 1998. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393: 474-478.
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, J.P.1    Di Rosa, F.2    Matzinger, P.3
  • 21
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger, S. P., R. E. Toes, E. I. van der Voort, R. Offringa, and C. J. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393: 480-483.
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    Voort Der Van, E.I.3    Offringa, R.4    Melief, C.J.5
  • 23
    • 0037058993 scopus 로고    scopus 로고
    • Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
    • Yee, C., J. A. Thompson, D. Byrd, S. R. Riddell, P. Roche, E. Celis, and P. D. Greenberg. 2002. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc. Natl. Acad. Sci. USA 99: 16168-16173.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16168-16173
    • Yee, C.1    Thompson, J.A.2    Byrd, D.3    Riddell, S.R.4    Roche, P.5    Celis, E.6    Greenberg, P.D.7
  • 25
    • 0035865742 scopus 로고    scopus 로고
    • An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs
    • Gottschalk, S., C. Y. Ng, M. Perez, C. A. Smith, C. Sample, M. K. Brenner, H. E. Heslop, and C. M. Rooney. 2001. An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs. Blood 97: 835-843.
    • (2001) Blood , vol.97 , pp. 835-843
    • Gottschalk, S.1    Ng, C.Y.2    Perez, M.3    Smith, C.A.4    Sample, C.5    Brenner, M.K.6    Heslop, H.E.7    Rooney, C.M.8
  • 30
    • 4344718859 scopus 로고    scopus 로고
    • 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function
    • Lee, S. J., L. Myers, G. Muralimohan, J. Dai, Y. Qiao, Z. Li, R. S. Mittler, and A. T. Vella. 2004. 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function. J. Immunol. 173: 3002-3012.
    • (2004) J. Immunol. , vol.173 , pp. 3002-3012
    • Lee, S.J.1    Myers, L.2    Muralimohan, G.3    Dai, J.4    Qiao, Y.5    Li, Z.6    Mittler, R.S.7    Vella, A.T.8
  • 31
    • 34848866873 scopus 로고    scopus 로고
    • CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent
    • Lee, S. J., R. J. Rossi, S. K. Lee, M. Croft, B. S. Kwon, R. S. Mittler, and A. T. Vella. 2007. CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent. J. Immunol. 179: 2203-2214.
    • (2007) J. Immunol. , vol.179 , pp. 2203-2214
    • Lee, S.J.1    Rossi, R.J.2    Lee, S.K.3    Croft, M.4    Kwon, B.S.5    Mittler, R.S.6    Vella, A.T.7
  • 32
    • 23944461007 scopus 로고    scopus 로고
    • Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice
    • Cuadros, C., A. L. Dominguez, P. L. Lollini, M. Croft, R. S. Mittler, P. Borgström, and J. Lustgarten. 2005. Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice. Int. J. Cancer 116: 934-943.
    • (2005) Int. J. Cancer , vol.116 , pp. 934-943
    • Cuadros, C.1    Dominguez, A.L.2    Lollini, P.L.3    Croft, M.4    Mittler, R.S.5    Borgström, P.6    Lustgarten, J.7
  • 33
    • 55249087266 scopus 로고    scopus 로고
    • Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies
    • Gray, J. C., R. R. French, S. James, A. Al-Shamkhani, P. W. Johnson, and M. J. Glennie. 2008. Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies. Eur. J. Immunol. 38: 2499-2511.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 2499-2511
    • Gray, J.C.1    French, R.R.2    James, S.3    Al-Shamkhani, A.4    Johnson, P.W.5    Glennie, M.J.6
  • 37
    • 0028179056 scopus 로고
    • Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
    • Huang, A. Y., P. Golumbek, M. Ahmadzadeh, E. Jaffee, D. Pardoll, and H. Levitsky. 1994. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264: 961-965.
    • (1994) Science , vol.264 , pp. 961-965
    • Huang, A.Y.1    Golumbek, P.2    Ahmadzadeh, M.3    Jaffee, E.4    Pardoll, D.5    Levitsky, H.6
  • 38
    • 0031821976 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
    • Kurts, C., J. F. Miller, R. M. Subramaniam, F. R. Carbone, and W. R. Heath. 1998. Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J. Exp. Med. 188: 409-414.
    • (1998) J. Exp. Med. , vol.188 , pp. 409-414
    • Kurts, C.1    Miller, J.F.2    Subramaniam, R.M.3    Carbone, F.R.4    Heath, W.R.5
  • 39
    • 0036911269 scopus 로고    scopus 로고
    • Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells
    • Spiotto, M. T., P. Yu, D. A. Rowley, M. I. Nishimura, S. C. Meredith, T. F. Gajewski, Y. X. Fu, and H. Schreiber. 2002. Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells. Immunity 17: 737-747.
    • (2002) Immunity , vol.17 , pp. 737-747
    • Spiotto, M.T.1    Yu, P.2    Rowley, D.A.3    Nishimura, M.I.4    Meredith, S.C.5    Gajewski, T.F.6    Fu, Y.X.7    Schreiber, H.8
  • 40
    • 0028359368 scopus 로고
    • Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor
    • Kirberg, J., A. Baron, S. Jakob, A. Rolink, K. Karjalainen, and H. von Boehmer. 1994. Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180: 25-34.
    • (1994) J. Exp. Med. , vol.180 , pp. 25-34
    • Kirberg, J.1    Baron, A.2    Jakob, S.3    Rolink, A.4    Karjalainen, K.5    Von Boehmer, H.6
  • 41
    • 0030848546 scopus 로고    scopus 로고
    • Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
    • Grubin, C. E., S. Kovats, P. deRoos, and A. Y. Rudensky. 1997. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7: 197-208.
    • (1997) Immunity , vol.7 , pp. 197-208
    • Grubin, C.E.1    Kovats, S.2    DeRoos, P.3    Rudensky, A.Y.4
  • 43
    • 84863605162 scopus 로고    scopus 로고
    • Area under the curve as a tool to measure kinetics of tumor growth in experimental animals
    • Duan, F., S. Simeone, R. Wu, J. Grady, I. Mandoiu, and P. K. Srivastava. 2012. Area under the curve as a tool to measure kinetics of tumor growth in experimental animals. J. Immunol. Methods 382: 224-228.
    • (2012) J. Immunol. Methods , vol.382 , pp. 224-228
    • Duan, F.1    Simeone, S.2    Wu, R.3    Grady, J.4    Mandoiu, I.5    Srivastava, P.K.6
  • 44
    • 0028906593 scopus 로고
    • T cell genetic background determines default T helper phenotype development in vitro
    • Hsieh, C. S., S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1995. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181: 713-721.
    • (1995) J. Exp. Med. , vol.181 , pp. 713-721
    • Hsieh, C.S.1    Macatonia, S.E.2    O'Garra, A.3    Murphy, K.M.4
  • 45
    • 84904038862 scopus 로고    scopus 로고
    • OX40 engagement depletes intratumoral Tregs via activating FcgRs, leading to antitumor efficacy
    • Bulliard, Y., R. Jolicoeur, J. Zhang, G. Dranoff, N. S. Wilson, and J. L. Brogdon. 2014. OX40 engagement depletes intratumoral Tregs via activating FcgRs, leading to antitumor efficacy. Immunol. Cell Biol. 92: 475-480.
    • (2014) Immunol. Cell Biol. , vol.92 , pp. 475-480
    • Bulliard, Y.1    Jolicoeur, R.2    Zhang, J.3    Dranoff, G.4    Wilson, N.S.5    Brogdon, J.L.6
  • 46
    • 8444234229 scopus 로고    scopus 로고
    • 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses
    • Dawicki, W., E. M. Bertram, A. H. Sharpe, and T. H. Watts. 2004. 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. J. Immunol. 173: 5944-5951.
    • (2004) J. Immunol. , vol.173 , pp. 5944-5951
    • Dawicki, W.1    Bertram, E.M.2    Sharpe, A.H.3    Watts, T.H.4
  • 47
    • 84863004847 scopus 로고    scopus 로고
    • Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness
    • Ngoi, S. M., M. C. St Rose, A. M. Menoret, D. E. Smith, M. G. Tovey, A. J. Adler, and A. T. Vella. 2012. Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness. Proc. Natl. Acad. Sci. USA 109: 10486-10491.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 10486-10491
    • Ngoi, S.M.1    St Rose, M.C.2    Menoret, A.M.3    Smith, D.E.4    Tovey, M.G.5    Adler, A.J.6    Vella, A.T.7
  • 48
    • 26244450446 scopus 로고    scopus 로고
    • T for two: When helpers need help
    • Zanetti, M. 2005. T for two: when helpers need help. Autoimmun. Rev. 4: 571-578.
    • (2005) Autoimmun. Rev. , vol.4 , pp. 571-578
    • Zanetti, M.1
  • 49
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of CD4+ T cell lineage differentiation
    • Zhou, L., M. M. Chong, and D. R. Littman. 2009. Plasticity of CD4+ T cell lineage differentiation. Immunity 30: 646-655.
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1    Chong, M.M.2    Littman, D.R.3
  • 50
    • 78650124721 scopus 로고    scopus 로고
    • Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice
    • Sharma, M. D., D. Y. Hou, B. Baban, P. A. Koni, Y. He, P. R. Chandler, B. R. Blazar, A. L. Mellor, and D. H. Munn. 2010. Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. Immunity 33: 942-954.
    • (2010) Immunity , vol.33 , pp. 942-954
    • Sharma, M.D.1    Hou, D.Y.2    Baban, B.3    Koni, P.A.4    He, Y.5    Chandler, P.R.6    Blazar, B.R.7    Mellor, A.L.8    Munn, D.H.9
  • 54
    • 84887211282 scopus 로고    scopus 로고
    • Regulation of Inflammation by Bidirectional Signaling through CD137 and Its Ligand
    • Kwon, B. 2012. Regulation of Inflammation by Bidirectional Signaling through CD137 and Its Ligand. Immune Netw. 12: 176-180.
    • (2012) Immune Netw. , vol.12 , pp. 176-180
    • Kwon, B.1
  • 55
    • 34548590892 scopus 로고    scopus 로고
    • Agonistic anti-4-1BB antibody promotes the expansion of natural regulatory T cells while maintaining Foxp3 expression
    • Zhang, P., F. Gao, Q. Wang, X. Wang, F. Zhu, C. Ma, W. Sun, and L. Zhang. 2007. Agonistic anti-4-1BB antibody promotes the expansion of natural regulatory T cells while maintaining Foxp3 expression. Scand. J. Immunol. 66: 435-440.
    • (2007) Scand. J. Immunol. , vol.66 , pp. 435-440
    • Zhang, P.1    Gao, F.2    Wang, Q.3    Wang, X.4    Zhu, F.5    Ma, C.6    Sun, W.7    Zhang, L.8
  • 56
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • Melero, I., J. V. Johnston, W. W. Shufford, R. S. Mittler, and L. Chen. 1998. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Immunol. 190: 167-172.
    • (1998) Cell. Immunol. , vol.190 , pp. 167-172
    • Melero, I.1    Johnston, J.V.2    Shufford, W.W.3    Mittler, R.S.4    Chen, L.5
  • 58
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • Ascierto, P. A., E. Simeone, M. Sznol, Y. X. Fu, and I. Melero. 2010. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin. Oncol. 37: 508-516.
    • (2010) Semin. Oncol. , vol.37 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.X.4    Melero, I.5


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