Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy

Clinical Epigenetics

Volumn 7, Issue 1, 2015, Pages

  Jones, Takako I ^a   King, Oliver D ^a,b   Himeda, Charis L ^a,b   Homma, Sachiko ^c   Chen, Jennifer C J ^a,b   Beermann, Mary Lou ^c   Yan, Chi ^a,d   Emerson, Charles P ^a,b   Miller, Jeffrey B ^c   Wagner, Kathryn R ^b,e   Jones, Peter L ^a,b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

D4Z4; Decitabine; Disease modifier; DNA methylation; DUX4; Epiallele; Epigenetic modifier; FSHD; Muscular dystrophy

Indexed keywords

DECITABINE; DNA; HOMEODOMAIN PROTEIN; REGULATOR PROTEIN; TRICHOSTATIN A;

ARTICLE; ASYMPTOMATIC DISEASE; CHROMOSOME 4Q; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; DRUG TARGETING; DUX4 GENE; EPIGENETIC REPRESSION; EPIGENETICS; FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY; FAMILY STUDY; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HETEROCHROMATIN; HOMEOBOX; HUMAN; HUMAN CELL; MUSCLE CELL; PATHOGENESIS; PRIORITY JOURNAL; RELATIVE;

EID: 84983048296     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-015-0072-6     Document Type: Article

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