Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

Oncotarget

Volumn 7, Issue 26, 2016, Pages 39065-39081

  Bai, Bo ^a,c   Man, Andy W C ^a   Kangmin Yang, ^a   Yumeng Guo, ^a   Cheng Xu, ^a   Tse, Hung Fat ^b   Han, Weiping ^c   Bloksgaard, Maria ^d   De Mey, Jo G R ^d   Vanhoutte, Paul M ^a   Xu, Aimin ^a,b   Wang, Yu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c AGENCY FOR SCIENCE   (Singapore)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Blood vessel remodeling; Endothelial senescence; Gerotarget; Hypertension; LKB1; SIRT1

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN PROTEIN LIGASE 2; PROTEIN KINASE; PROTEIN KINASE LKB1; SIRTUIN 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HERC2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SIRT1 PROTEIN, HUMAN; STK11 PROTEIN, HUMAN; UBIQUITIN;

AGING; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOACCUMULATION; CELL AGING; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE FUNCTION; GENE IDENTIFICATION; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN PROTEIN LIGASE 2 GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; SIRTUIN 1 GENE; SITE DIRECTED MUTAGENESIS; VASCULAR AGING; VASCULAR REMODELING; VASCULAR SMOOTH MUSCLE CELL; 3T3-L1 CELL LINE; ACETYLATION; ANIMAL; ARTERY; CAROTID ARTERY; CHEMISTRY; ENDOTHELIUM CELL; GENETICS; HOMEOSTASIS; METABOLISM; PATHOLOGY; PROTEIN PROCESSING; TRANSGENIC MOUSE; TUMOR CELL LINE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

3T3-L1 CELLS; ACETYLATION; ANIMALS; ARTERIES; CAROTID ARTERIES; CELL LINE, TUMOR; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HOMEOSTASIS; HUMANS; MICE; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; MUTAGENESIS, SITE-DIRECTED; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; SIRTUIN 1; UBIQUITIN; VASCULAR REMODELING;

EID: 84982903048     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9687     Document Type: Article

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