Atopic dermatitis: New evidence on the role of allergic inflammation

Current Opinion in Allergy and Clinical Immunology

Volumn 16, Issue 5, 2016, Pages 458-464

  Heratizadeh, Annice ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

adaptive immune response; allergen; atopic dermatitis; T cell

Indexed keywords

ALLERGEN; FOOD ALLERGEN; HOUSE DUST ALLERGEN; POLLEN ANTIGEN; AUTOANTIGEN; BACTERIAL ANTIGEN;

ADAPTIVE IMMUNITY; ALLERGY; ATOPIC DERMATITIS; DERMATOPHAGOIDES; FOOD ALLERGY; GRASS POLLEN; HOUSE DUST ALLERGY; HUMAN; IN VITRO STUDY; INFLAMMATION; MALASSEZIA; MULTICENTER STUDY (TOPIC); NONHUMAN; POLLEN ALLERGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STAPHYLOCOCCUS AUREUS; SYSTEMATIC REVIEW (TOPIC); ANIMAL; CROSS REACTION; IMMUNOLOGY; PERSONALIZED MEDICINE; TH17 CELL; TH2 CELL;

ADAPTIVE IMMUNITY; ALLERGENS; ANIMALS; ANTIGENS, BACTERIAL; AUTOANTIGENS; CROSS REACTIONS; DERMATITIS, ATOPIC; HUMANS; INFLAMMATION; PRECISION MEDICINE; TH17 CELLS; TH2 CELLS;

EID: 84982843546     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0000000000000308     Document Type: Review

References (52)

1. Paternoster L, Standl M, Waage J, et al. Multiancestry genome-wide association study of 21 000 cases and 95 000 controls identifies new risk loci for atopic dermatitis. Nat Genet 2015; 47:1449-1456.
2. Heratizadeh A, Wichmann K, Werfel T. Food allergy and atopic dermatitis: how are they connected? Curr Allergy Asthma Rep 2011; 11:284-291.
3. Flohr C, Perkin M, Logan K, et al. Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants. J Invest Dermatol 2014; 134:345-350.
4. Reekers R, Busche M, Wittmann M, et al. Birch pollen-related foods trigger atopic dermatitis in patients with specific cutaneous T-cell responses to birch pollen antigens. J Allergy Clin Immunol 1999; 104:466-472.
5. Werfel T, Asero R, Ballmer-Weber BK, et al. Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens. Allergy 2015; 70:1079-1090.
6. Bohle B, Zwolfer B, Heratizadeh A, et al. Cooking birch pollen-related food: divergent consequences for IgE-and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol 2006; 118:242-249.
7. Manam S, Tsakok T, Till S, et al. The association between atopic dermatitis and food allergy in adults. Curr Opin Allergy Clin Immunol 2014; 14:423-429.
8. Tsakok T, Marrs T, Mohsin M, et al. Does atopic dermatitis cause food allergy? A systematic review. J Allergy Clin Immunol 2016; 137:1071-1078.
9. Muraro A, Agache I, Clark A, et al. EAACI food allergy and anaphylaxis guidelines: managing patients with food allergy in the community. Allergy 2014; 69:1046-1057.
10. Kramer U, Weidinger S, Darsow U, et al. Seasonality in symptom severity influenced by temperature or grass pollen: results of a panel study in children with eczema. J Invest Dermatol 2005; 124:514-523.
11. Fö lster-Holst R, Galecka J, Weissmantel S, et al. Birch pollen influence the severity of atopic eczema: prospective clinical cohort pilot study and ex vivo penetration study. Clin Cosmet Investig Dermatol 2015; 8:539-548.
12. Dharmage SC, Lowe AJ, Matheson MC, et al. Atopic dermatitis and the atopic march revisited. Allergy 2014; 69:17-27.
13. Marenholz I, Esparza-Gordillo J, Ruschendorf F, et al. Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat Commun 2015; 6:8804.
14. Turjanmaa K, Darsow U, Niggemann B, et al. EAACI/GA2LEN position paper: present status of the atopy patch test. Allergy 2006; 61:1377-1384.
15. Pfaar O, van Twuijver E, Boot JD, et al. A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT-birch pollen extract for the treatment of allergic rhinitis: results of a phase II study. Allergy 2016; 71:99-107.
16. Tupker RA, De Monchy JG, Coenraads PJ, et al. Induction of atopic dermatitis by inhalation of house dust mite. J Allergy Clin Immunol 1996; 97:1064-1070.
17. Werfel T, Heratizadeh A, Aberer W, et al. S2k guideline on diagnosis and treatment of atopic dermatitis. J Dtsch Dermatol Ges 2016; 14:92-106.
18. Novak N, Bieber T, Hoffmann M, et al. Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis. J Allergy Clin Immunol 2012; 130:925-931.
19. Werfel T, Breuer K, Rueff F, et al. Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multicentre, randomized, dose-response study. Allergy 2006; 61:202-205.
20. Tam H, Calderon MA, Manikam L, et al. Specific allergen immunotherapy for the treatment of atopic eczema. Cochrane Database Syst Rev 2016; 2:CD008774.
21. Roesner LM, Werfel T, Heratizadeh A. The adaptive immune system in atopic dermatitis and implications on therapy. Expert Rev Clin Immunol 2016; 12:787-796.
22. Roesner LM, Heratizadeh A, Begemann G, et al. Der p1 and der p2-specific T cells display a Th2, Th17, and Th2/Th17 phenotype in atopic dermatitis. J Invest Dermatol 2015; 135:2324-2327.
23. Banerjee S, Resch Y, Chen KW, et al. Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis. J Invest Dermatol 2015; 135:102-109.
24. Rost GA. Experience with an allergen-free chamber adapted from Storm van Leeuwen; particularly during the late phase of exudative diathesis [in German]. Arch Dermatol Syphilol 1928; 155:297-308.
25. Darsow U, Laifaoui J, Kerschenlohr K, et al. The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study. Allergy 2004; 59:1318-1325.
26. Werfel T, Heratizadeh A, Niebuhr M, et al. Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber. J Allergy Clin Immunol 2015; 136:96-103.
27. Lueer K, Biller H, Casper A, et al. Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber. Allergy 2016. doi: 10.1111/all.12947.
28. Thijs J, Krastev T, Weidinger S, et al. Biomarkers for atopic dermatitis: a systematic review and meta-analysis. Curr Opin Allergy Clin Immunol 2015; 15:453-460.
29. Till SJ, Raynsford EJ, Reynolds CJ, et al. Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation. Thorax 2014; 69:335-345.
30. Gilles-Stein S, Beck I, Chaker A, et al. Pollen derived low molecular compounds enhance the human allergen specific immune response in vivo. Clin Exp Allergy 2016. doi: 10.1111/cea.12739.
31. Tauber M, Balica S, Hsu CY, et al. Staphylococcus aureus density on lesional and nonlesional skin is strongly associated with disease severity in atopic dermatitis. J Allergy Clin Immunol 2016; 137:1272-1274.
32. Wichmann K, Uter W, Weiss J, et al. Isolation of alpha-toxin-producing Staphylococcus aureus from the skin of highly sensitized adult patients with severe atopic dermatitis. Br J Dermatol 2009; 161:300-305.
33. Breuer K, Wittmann M, Bosche B, et al. Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB). Allergy 2000; 55:551-555.
34. Sonkoly E, Muller A, Lauerma AI, et al. IL-31: a newlink between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 2006; 117:411-417.
35. Nakajima S, Kitoh A, Egawa G, et al. IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models. J Invest Dermatol 2014; 134:2122-2130.
36. Reginald K, Westritschnig K, Linhart B, et al. Staphylococcus aureus fibronectin-binding protein specifically binds IgE from patients with atopic dermatitis and requires antigen presentation for cellular immune responses. J Allergy Clin Immunol 2011; 128:82-91.
37. Kong HH, Oh J, Deming C, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res 2012; 22:850-859.
38. Kekki OM, Scheynius A, Poikonen S, et al. Sensitization to Malassezia in children with atopic dermatitis combined with food allergy. Pediatr Allergy Immunol 2013; 24:244-249.
39. Gaitanis G, Velegraki A, Mayser P, et al. Skin diseases associated with Malassezia yeasts: facts and controversies.Clin Dermatol 2013; 31:455-463.
40. Brodska P, Panzner P, Pizinger K, et al. IgE-mediated sensitization to malassezia in atopic dermatitis: more common in male patients and in head and neck type. Dermatitis 2014; 25:120-126.
41. Glatz M, Buchner M, von Bartenwerffer W, et al. Malassezia spp.-specific immunoglobulin E level is a marker for severity of atopic dermatitis in adults. Acta Derm Venereol 2015; 95:191-196.
42. Johansson C, Sandstrom MH, Bartosik J, et al. Atopy patch test reactions to Malassezia allergens differentiate subgroups of atopic dermatitis patients. Br J Dermatol 2003; 148:479-488.
43. Johansson C, Ahlborg N, Andersson A, et al. Elevated peripheral allergenspecific T cell response is crucial for a positive atopy patch test reaction. Int Arch Allergy Immunol 2009; 150:51-58.
44. Balaji H, Heratizadeh A, Wichmann K, et al. Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. J Allergy Clin Immunol 2011; 128:92-99.
45. Limacher A, Glaser AG, Meier C, et al. Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family. J Immunol 2007; 178:389-396.
46. Tang TS, Bieber T, Williams HC. Does 'autoreactivity' play a role in atopic dermatitis? J Allergy Clin Immunol 2012; 129:1209-1215.
47. Valenta R, Seiberler S, Natter S, et al. Autoallergy: a pathogenetic factor in atopic dermatitis? J Allergy Clin Immunol 2000; 105:432-437.
48. Werfel T, Allam JP, Biedermann T, et al. Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J Allergy Clin Immunol 2016. (in press)
49. Storm van Leeuwen W, Bien Z, Varekamp H. Skin reactions to human dandruff extracts in allergic diseases [in German]. Klin Wochenschr 1926; 5:1023-1225.
50. Heratizadeh A, Mittermann I, Balaji H, et al. The role of T-cell reactivity towards the autoantigen a-NAC in atopic dermatitis. Br J Dermatol 2011; 164:316-324.
51. Roesner LM, Heratizadeh A, Wieschowski S, et al. a-NAC-specific autoreactive CD8\+ T cells in atopic dermatitis are of an effector memory type and secrete IL-4 and IFN-g. J Immunol 2016; 196:3245-3252.
52. Hradetzky S, Roesner LM, Balaji H, et al. Cytokine effects induced by the human autoallergen a-NAC. J Invest Dermatol 2014; 134:1570-1578.