Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: A multi-centre, randomized, dose-response study

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 61, Issue 2, 2006, Pages 202-205

  Werfel, T ^a   Breuer, K ^a   Rueff F ^b   Przybilla, B ^b   Worm, M ^c   Grewe, M ^d   Ruzicka, T ^d   Brehler, R ^e   Wolf, H ^f   Schnitker, J ^g   Kapp, A ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^f ALK SCHERAX Arzneimittel GmbH   (Germany)

^g Institut für Angewandte Statistik IAS   (Germany)

Author keywords

Atopic dermatitis; Eczema; House dust mite; Hyposensitization; Specific immunotherapy

Indexed keywords

CORTICOSTEROID; HOUSE DUST ALLERGEN;

ADULT; ARTICLE; ATOPIC DERMATITIS; CHI SQUARE TEST; CHRONIC DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMATOPHAGOIDES; DISEASE COURSE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; DRUG USE; ECZEMA; FEMALE; HUMAN; IMMUNOTHERAPY; MAINTENANCE DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MANTEL HAENSZEL TEST; MULTICENTER STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SKIN SENSITIZATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; URTICARIA;

ADOLESCENT; ADULT; ALLERGENS; ANTIGENS, DERMATOPHAGOIDES; DERMATITIS, ATOPIC; DESENSITIZATION, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; HYPERSENSITIVITY; MALE; MIDDLE AGED; PYROGLYPHIDAE;

EID: 33644914465     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2006.00974.x     Document Type: Article

References (15)

1. Werfel T Kapp A Environmental and other major provocation factors in atopic dermatitis Allergy 1998 53 731 739
2. Mitchell EB Crow J Chapman MD Jouhal SS Pope FM Platts-Mills TA Basophils in allergen-induced patch test sites in atopic dermatitis Lancet 1982 16 127 130
3. Sager N Feldmann A Schilling G Kreitsch P Neumann C House dust mite-specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test J Allergy Clin Immunol 1992 89 801 810
4. Di Prisco de Fuenmayor MC Champion RH Specific hyposensitization in atopic dermatitis Br J Dermatol 1979 101 697 700
5. Ring J Successful hyposensitization treatment in atopic eczema: results of a trial in monozygotic twins Br J Dermatol 1982 107 597 602
6. Zachariae H Cramers M Herlin T Jensen J Kragballe K Ternowitz T et al. Non-specific immunotherapy and specific hyposensitization in severe atopic dermatitis Acta Derm Venereol Suppl (Stockh) 1985 114 48 54
7. Seidenari S Mosca M Taglietti M Manco S Nume G Specific hyposensitization in atopic dermatitis Dermatologica 1986 172 229
8. Pacor ML Biasi D Maleknia T The efficacy of long-term specific immunotherapy for Dermatophagoides pteronyssinus in patients with atopic dermatitis Recenti Prog Med 1994 85 273 277
9. Trofimowicz A Rzepecka E Hofman J Clinical effects of specific immunotherapy in children with atopic dermatitis Rocz Akad Med Bialymst 1995 40 414 422
10. Galli E Chini L Nardi S Benincori N Panei P Fraioli G et al. Use of a specific oral hyposensitization therapy to Dermatophagoides pteronyssinus in children with atopic dermatitis Allergol Immunopathol 1994 22 18 22
11. Leroy BP Boden G Lachapelle JM Jacquemin MG Saint-Remy JM A novel therapy for atopic dermatitis with allergen-antibody complexes: a double-blind, placebo-controlled study J Am Acad Dermatol 1993 28 232 239
12. Consensus Report of the European Task Force on Atopic Dermatitis Dermatology. Severity scoring of atopic dermatitis: The SCORAD index Dermatology 1993 186 23 31
13. Mastrandrea F Immunotherapy in atopic dermatitis Expert Opin Investig Drugs 2001 10 49 63
14. Werfel T Morita A Grewe M Renz H Wahn U Krutmann J et al. Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis J Invest Dermatol 1996 107 871 876
15. Grewe M Bruijnzeel-Koomen CA Schopf E Thepen T Langeveld-Wildschut AG Ruzicka T et al. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis Immunol Today 1998 19 359 361