New biochemical insights into the mechanisms of pulmonary arterial hypertension in humans

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Bujak, Renata ^a,b   Mateo, Jesús ^c,f   Blanco, Isabel ^d,f   Izquierdo García, José Luis ^c,f   Dudzik, Danuta ^a   Markuszewski, Michał J ^b   Peinado, Victor Ivo ^d,f   Laclaustra, Martín ^c,e   Barberá, Joan Albert ^d,f   Barbas, Coral ^a   Ruiz Cabello, Jesús ^c,f,g  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

^g UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

THREITOL; BIOLOGICAL MARKER;

ACCURACY; AMINO ACID METABOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ELECTROSPRAY MASS SPECTROMETRY; FATTY ACID METABOLISM; GAS CHROMATOGRAPHY; GLYCOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IONIZATION; LIPID METABOLISM; METABOLOMICS; PREDICTIVE VALUE; PULMONARY HYPERTENSION; VALIDITY; ADULT; BLOOD; BLOOD ANALYSIS; CASE CONTROL STUDY; FEMALE; HYPERTENSION, PULMONARY; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; PROCEDURES; SPAIN;

ADULT; BIOMARKERS; BLOOD CHEMICAL ANALYSIS; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYPERTENSION, PULMONARY; MALE; METABOLOMICS; SPAIN;

EID: 84982187308     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0160505     Document Type: Article

References (41)

1. Dweik RA, Rounds S, Erzurum SC, Archer S, Fagan K, Hassoun PM, et al. An official American Thoracic Society Statement: pulmonary hypertension phenotypes. Am J Respir Crit Care Med. 2014; 189: 345-355. doi: 10.1164/rccm.201311-1954ST PMID: 24484330
2. Pak O, Janssen W, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, et al. Animal models of pulmonary hypertension: role in translational research. Drug Discov Today. 2010; 7: 89-97.
3. Jurasz P, Courtman D, Babaie S, Stewart DJ. Role of apoptosis in pulmonary hypertension: From experimental models to clinical trials. Pharmacol Therapeut. 2010; 126: 1-8.
4. Nicholson JK, Lindon JC, Holmes E. "Metabonomics": understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999; 29: 1181-1189. PMID: 10598751
5. Fiehn O. Combining genomics, metabolome analysis, and biochemical modeling to understand metabolic networks. Comp Funct Genom. 2001; 2: 155-168.
6. Sutendra G, Michelakis ED. The metabolic basis of pulmonary arterial hypertension. Cell Metab. 2014; 19: 558-573 doi: 10.1016/j.cmet.2014.01.004 PMID: 24508506
7. Zhao Y, Peng J, Lu C, Hsin M, Mura M, Wu L, et al. Metabolomic heterogeneity of pulmonary arterial hypertension. PLoS One. 2014; 9: e88727. doi: 10.1371/ journal.pone.0088727 PMID: 24533144
8. Cottrill KA, Chan SY. Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect. Eur J Clin Invest. 2013; 43: 855-865. doi: 10.1111/eci.12104 PMID: 23617881
9. Xu W, Koeck T, Lara AR, Neumann D, DiFilippo FP, Koo M, et al. Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc Natl Acad Sci U S A. 2007; 104: 1342-1347. PMID: 17227868
10. Pitkänen E. The conversion of D-xylose into D-threitol in patients without liver disease and in patients with portal liver cirrhosis. Clin Chim Acta. 1977; 80: 49-54. PMID: 908147
11. Aloia JF. Monosaccharides and polyols in diabetes mellitus and uremia. J Lab Clin Med. 1973; 82: 809-817. PMID: 4746819
12. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer. 2011; 11: 85-95. doi: 10.1038/nrc2981 PMID: 21258394
13. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003; 423: 550-555. PMID: 12754525
14. Rinaldo P, Cowan TM, Matern D. Acylcarnitine profile analysis. Genet Med. 2008; 10: 151-156. doi: 10.1097/GIM.0b013e3181614289 PMID: 18281923
15. Adams SH, Hoppel CL, Lok KH, Zhao L, Wong SW, Minkler PE, et al. Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr. 2009; 139: 1073-1081. doi: 10.3945/jn.108.103754 PMID: 19369366
16. Archer SL, Fang YH, Ryan JJ, Piao L. Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension. Pulm Circ. 2013; 3: 144-152. doi: 10.4103/2045-8932.109960 PMID: 23662191
17. Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant. 2011; 30: 904-911. doi: 10.1016/j.healun.2011.02.016 PMID: 21493097
18. Fijalkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, et al. Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells. Am J Pathol. 2010; 176: 1130-1138. doi: 10.2353/ajpath.2010.090832 PMID: 20110409
19. Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, et al. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation. 2006; 113: 2630-2641. PMID: 16735674
20. Pillarisetti S, Alexander CW, Khanna I. Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases. Drug Discov Today. 2009; 14: 1098-1111. doi: 10.1016/j.drudis.2009.08.002 PMID: 19716430
21. Sudhahar V, Shaw S, Imig JD. Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. Eur J Pharmacol. 2009; 607: 143-150. PMID: 19326479
22. Guzman M, Lo Verme J, Fu J, Oveisi F, Blázquez C, Piomelli D. Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J Biol Chem. 2004; 279: 27849-27854. PMID: 15123613
23. Overton HA, Fyfe MC, Reynet C. GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. Br J Pharmacol. 2008; 153: 76-81.
24. Bartke N, Hannun YA. Bioactive sphingolipids: metabolism and function. J Lipid Res. 2009; 50: 91-96.
25. Van Veldhoven PP, Mannaerts GP, Declercq P, Baes M. Do sphingoid bases interact with the peroxisome proliferator activated receptor alpha (PPAR-alpha)? Cell Signal. 2000; 12: 475-479. PMID: 10989283
26. van Raalte DH, Li M, Pritchard PH, Wasan KM. Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future. Pharm Res. 2004; 21: 1531-1538. PMID: 15497675
27. Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, et al. The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014; 190(9):1032-1043. doi: 10.1164/rccm.201401-0121OC PMID: 25180446
28. de Aguiar Vallim TQ, Tarling EJ, Edwards PA. Pleiotropic roles of bile acids in metabolism. Cell Metab. 2013; 17: 657-669. doi: 10.1016/j.cmet.2013.03.013 PMID: 23602448
29. Zhao YD, Yun HZ, Peng J, Yin L, Chu L, Wu L, et al. De novo synthesize of bile acids in pulmonary arterial hypertension lung. Metabolomics. 2014; 10: 1169-1175. PMID: 25374487
30. Dang CV. Glutaminolysis: supplying carbon or nitrogen or both for cancer cells? Cell Cycle. 2010; 9: 3884-3886. PMID: 20948290
31. Piao L, Fang YH, Parikh K, Ryan JJ, Toth PT, Archer SL. Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. J Mol Med (Berl). 2013; 91: 1185-1197.
32. MacLean MR, Herve P, Eddahibi S, Adnot S. 5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension. Br J Pharmacol. 2000; 131: 161-168. PMID: 10991906
33. Walther DJ, Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol. 2003; 66: 1673-1680. PMID: 14563478
34. Eddahibi S, Guignabert C, Barlier-Mur AM, Dewachter L, Fadel E, Dartevelle P, et al. Cross talk between endothelial and smooth muscle cells in pulmonary hypertension - critical role for serotonin-induced smooth muscle hyperplasia. Circulation. 2006; 113: 1857-1864. PMID: 16606791
35. Morecroft I, Dempsie Y, Bader M, Walther DJ, Kotnik K, Loughlin L, et al. Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. Hypertension. 2007; 49: 232-236. PMID: 17130306
36. Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, et al. The human serum metabolome. PLoS One. 2011; 6(2): e16957. doi: 10.1371/journal.pone.0016957 PMID: 21359215
37. Van Buskirk JJ, Kirsch WM, Kleyer DL, Barkley RM, Koch TH. Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A. 1984; 81: 722-725. PMID: 6366787
38. Chakrabarti M, Cheng KT, Spicer KM, Kirsch WM, Fowler SD, Kelln W, et al. Biodistribution and radioimmunopharmacokinetics of 131I-Ama monoclonal antibody in atherosclerotic rabbits. Nucl Med Biol. 1995; 22: 693-697. PMID: 8535329
39. Dean RT, Fu S, Stocker R, Davies MJ. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J. 1997; 324 (Pt 1): 1-18. PMID: 9164834
40. Rupérez FJ, Ramos-Mozo P, Teul J, Martinez-Pinna R, Garcia A, Malet-Martino M, et al. Metabolomic study of plasma of patients with abdominal aortic aneurysm. Anal Bioanal Chem. 2012; 403: 1651-1660. doi: 10.1007/s00216-012-5982-y PMID: 22543712
41. Bowers R, Cool C, Murphy RC, Tuder RM, Hopken MW, Flores SC, et al. Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med. 2004; 169: 764-769. PMID: 14701708