-
1
-
-
79955399340
-
Definition and classification of cancer cachexia: An international consensus
-
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011;12:489-95.
-
(2011)
Lancet Oncol
, vol.12
, pp. 489-495
-
-
Fearon, K.1
Strasser, F.2
Anker, S.D.3
Bosaeus, I.4
Bruera, E.5
Fainsinger, R.L.6
-
2
-
-
0030688961
-
ABC of palliative care. Anorexia, cachexia, and nutrition
-
Bruera E. ABC of palliative care. Anorexia, cachexia, and nutrition. BMJ 1997;315:1219-22.
-
(1997)
BMJ
, vol.315
, pp. 1219-1222
-
-
Bruera, E.1
-
3
-
-
0031012340
-
Changes in nutritional status associated with unresectable pancreatic cancer
-
Wigmore SJ, Plester CE, Richardson RA, Fearon KC. Changes in nutritional status associated with unresectable pancreatic cancer. Br J Cancer 1997; 75:106-9.
-
(1997)
Br J Cancer
, vol.75
, pp. 106-109
-
-
Wigmore, S.J.1
Plester, C.E.2
Richardson, R.A.3
Fearon, K.C.4
-
4
-
-
0032033321
-
Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?
-
Andreyev HJ, Norman AR, Oates J, Cunningham D. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? Eur J Cancer 1998;34:503-9.
-
(1998)
Eur J Cancer
, vol.34
, pp. 503-509
-
-
Andreyev, H.J.1
Norman, A.R.2
Oates, J.3
Cunningham, D.4
-
5
-
-
84906069822
-
Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: From sarcopenic obesity to cachexia
-
Biolo G, Cederholm T, Muscaritoli M. Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia. Clin Nutr 2014;33:737-48.
-
(2014)
Clin Nutr
, vol.33
, pp. 737-748
-
-
Biolo, G.1
Cederholm, T.2
Muscaritoli, M.3
-
6
-
-
77955702860
-
Reversing cachexia
-
Tisdale MJ. Reversing cachexia. Cell 2010;142:511-2.
-
(2010)
Cell
, vol.142
, pp. 511-512
-
-
Tisdale, M.J.1
-
7
-
-
84885174406
-
Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential
-
Han HQ, Zhou X, Mitch WE, Goldberg AL. Myostatin/activin pathway antagonism: molecular basis and therapeutic potential. Int J Biochem Cell Biol 2013;45:2333-47.
-
(2013)
Int J Biochem Cell Biol
, vol.45
, pp. 2333-2347
-
-
Han, H.Q.1
Zhou, X.2
Mitch, W.E.3
Goldberg, A.L.4
-
8
-
-
84864646651
-
Cancer cachexia: Mediators, signaling, and metabolic pathways
-
Fearon KC, Glass DJ, Guttridge DC. Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab 2012;16:153-66.
-
(2012)
Cell Metab
, vol.16
, pp. 153-166
-
-
Fearon, K.C.1
Glass, D.J.2
Guttridge, D.C.3
-
9
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman MH, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002; 82:373-428.
-
(2002)
Physiol Rev
, vol.82
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
10
-
-
36448968532
-
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
-
Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, et al. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 2007;6:472-83.
-
(2007)
Cell Metab
, vol.6
, pp. 472-483
-
-
Zhao, J.1
Brault, J.J.2
Schild, A.3
Cao, P.4
Sandri, M.5
Schiaffino, S.6
-
11
-
-
0036295676
-
Molecular regulation of muscle cachexia: It may be more than the proteasome
-
Hasselgren PO, Wray C, Mammen J. Molecular regulation of muscle cachexia: it may be more than the proteasome. Biochem Biophys Res Commun 2002;290:1-10.
-
(2002)
Biochem Biophys Res Commun
, vol.290
, pp. 1-10
-
-
Hasselgren, P.O.1
Wray, C.2
Mammen, J.3
-
12
-
-
84925454325
-
Role of interleukin-6 in cachexia: Therapeutic implications
-
Narsale AA, Carson JA. Role of interleukin-6 in cachexia: therapeutic implications. Curr Opin Support Palliat Care 2014;8:321-7.
-
(2014)
Curr Opin Support Palliat Care
, vol.8
, pp. 321-327
-
-
Narsale, A.A.1
Carson, J.A.2
-
13
-
-
0033696398
-
NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes
-
Li YP, Reid MB. NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am J Physiol Regul Integr Comp Physiol 2000;279:R1165-70.
-
(2000)
Am J Physiol Regul Integr Comp Physiol
, vol.279
, pp. R1165-R1170
-
-
Li, Y.P.1
Reid, M.B.2
-
14
-
-
0027372066
-
Acute treatment with tumour necrosis factor-alpha induces changes in protein metabolism in rat skeletal muscle
-
Garcia-Martinez C, Lopez-Soriano FJ, Argiles JM. Acute treatment with tumour necrosis factor-alpha induces changes in protein metabolism in rat skeletal muscle. Mol Cell Biochem 1993;125:11-8.
-
(1993)
Mol Cell Biochem
, vol.125
, pp. 11-18
-
-
Garcia-Martinez, C.1
Lopez-Soriano, F.J.2
Argiles, J.M.3
-
15
-
-
0000498853
-
Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins
-
Fong Y, Moldawer LL, Marano M, Wei H, Barber A, Manogue K, et al. Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. Am J Physiol 1989;256:R659-65.
-
(1989)
Am J Physiol
, vol.256
, pp. R659-R665
-
-
Fong, Y.1
Moldawer, L.L.2
Marano, M.3
Wei, H.4
Barber, A.5
Manogue, K.6
-
16
-
-
0031802331
-
Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha
-
Li YP, Schwartz RJ, Waddell ID, Holloway BR, Reid MB. Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. FASEB J 1998;12: 871-80.
-
(1998)
FASEB J
, vol.12
, pp. 871-880
-
-
Li, Y.P.1
Schwartz, R.J.2
Waddell, I.D.3
Holloway, B.R.4
Reid, M.B.5
-
17
-
-
0036208356
-
Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy
-
Hunter RB, Stevenson E, Koncarevic A, Mitchell-Felton H, Essig DA, Kandarian SC. Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy. FASEB J 2002;16:529-38.
-
(2002)
FASEB J
, vol.16
, pp. 529-538
-
-
Hunter, R.B.1
Stevenson, E.2
Koncarevic, A.3
Mitchell-Felton, H.4
Essig, D.A.5
Kandarian, S.C.6
-
18
-
-
5444262078
-
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
-
Cai D, Frantz JD, Tawa NEJr, Melendez PA, Oh BC, Lidov HG, et al. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 2004;119:285-98.
-
(2004)
Cell
, vol.119
, pp. 285-298
-
-
Cai, D.1
Frantz, J.D.2
Tawa, N.E.3
Melendez, P.A.4
Oh, B.C.5
Lidov, H.G.6
-
19
-
-
84864515569
-
JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
-
Bonetto A, Aydogdu T, Jin X, Zhang Z, Zhan R, Puzis L, et al. JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia.AmJ Physiol Endocrinol Metab 2012;303: E410-21.
-
(2012)
AmJ Physiol Endocrinol Metab
, vol.303
, pp. E410-E421
-
-
Bonetto, A.1
Aydogdu, T.2
Jin, X.3
Zhang, Z.4
Zhan, R.5
Puzis, L.6
-
20
-
-
0031010050
-
Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
-
McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 1997;387:83-90.
-
(1997)
Nature
, vol.387
, pp. 83-90
-
-
McPherron, A.C.1
Lawler, A.M.2
Lee, S.J.3
-
21
-
-
2942735123
-
Myostatin mutation associated with gross muscle hypertrophy in a child
-
Schuelke M, Wagner KR, Stolz LE, Hubner C, Riebel T, Komen W, et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 2004;350:2682-8.
-
(2004)
N Engl J Med
, vol.350
, pp. 2682-2688
-
-
Schuelke, M.1
Wagner, K.R.2
Stolz, L.E.3
Hubner, C.4
Riebel, T.5
Komen, W.6
-
22
-
-
0036486076
-
Regulation of cell proliferation, apoptosis, and carcinogenesis by activin
-
Chen YG, Lui HM, Lin SL, Lee JM, Ying SY. Regulation of cell proliferation, apoptosis, and carcinogenesis by activin. Exp Biol Med (Maywood) 2002;227:75-87.
-
(2002)
Exp Biol Med (Maywood)
, vol.227
, pp. 75-87
-
-
Chen, Y.G.1
Lui, H.M.2
Lin, S.L.3
Lee, J.M.4
Ying, S.Y.5
-
23
-
-
33744982427
-
Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis
-
Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Ying SY. Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Exp Biol Med (Maywood) 2006;231:534-44.
-
(2006)
Exp Biol Med (Maywood)
, vol.231
, pp. 534-544
-
-
Chen, Y.G.1
Wang, Q.2
Lin, S.L.3
Chang, C.D.4
Chuang, J.5
Ying, S.Y.6
-
24
-
-
66749167618
-
Smad2 and 3 transcription factors control muscle mass in adulthood
-
Sartori R, Milan G, Patron M, Mammucari C, Blaauw B, Abraham R, et al. Smad2 and 3 transcription factors control muscle mass in adulthood. Am J Physiol Cell Physiol 2009;296:C1248-57.
-
(2009)
Am J Physiol Cell Physiol
, vol.296
, pp. C1248-C1257
-
-
Sartori, R.1
Milan, G.2
Patron, M.3
Mammucari, C.4
Blaauw, B.5
Abraham, R.6
-
25
-
-
4544293878
-
IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophyrelated ubiquitin ligases, atrogin-1 and MuRF1
-
Sacheck JM, Ohtsuka A, McLary SC, Goldberg AL. IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophyrelated ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 2004;287:E591-601.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
, pp. E591-E601
-
-
Sacheck, J.M.1
Ohtsuka, A.2
McLary, S.C.3
Goldberg, A.L.4
-
26
-
-
0035735902
-
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/ mTOR and PI(3)K/Akt/GSK3 pathways
-
Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, et al. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/ mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol 2001;3:1009-13.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 1009-1013
-
-
Rommel, C.1
Bodine, S.C.2
Clarke, B.A.3
Rossman, R.4
Nunez, L.5
Stitt, T.N.6
-
27
-
-
38649091396
-
Fast/ glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice
-
Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, et al. Fast/ glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab 2008;7:159-72.
-
(2008)
Cell Metab
, vol.7
, pp. 159-172
-
-
Izumiya, Y.1
Hopkins, T.2
Morris, C.3
Sato, K.4
Zeng, L.5
Viereck, J.6
-
29
-
-
84906794310
-
TGFbeta and BMP signaling in skeletal muscle: Potential significance for muscle-related disease
-
Sartori R, Gregorevic P, Sandri M. TGFbeta and BMP signaling in skeletal muscle: potential significance for muscle-related disease. Trends Endocrinol Metab 2014;25:464-71.
-
(2014)
Trends Endocrinol Metab
, vol.25
, pp. 464-471
-
-
Sartori, R.1
Gregorevic, P.2
Sandri, M.3
-
30
-
-
66749188280
-
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size
-
Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ. Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. Am J Physiol Cell Physiol 2009;296: C1258-70.
-
(2009)
Am J Physiol Cell Physiol
, vol.296
, pp. C1258-C1270
-
-
Trendelenburg, A.U.1
Meyer, A.2
Rohner, D.3
Boyle, J.4
Hatakeyama, S.5
Glass, D.J.6
-
31
-
-
84949895181
-
Cachexia: The last illness
-
Lok C. Cachexia: the last illness. Nature 2015;528:182-3.
-
(2015)
Nature
, vol.528
, pp. 182-183
-
-
Lok, C.1
-
33
-
-
0032867672
-
Use of recombinant human soluble TNF receptor in anorectic tumorbearing rats
-
Torelli GF, Meguid MM, Moldawer LL, Edwards CKIII, Kim HJ, Carter JL, et al. Use of recombinant human soluble TNF receptor in anorectic tumorbearing rats. Am J Physiol 1999;277:R850-5.
-
(1999)
Am J Physiol
, vol.277
, pp. R850-R855
-
-
Torelli, G.F.1
Meguid, M.M.2
Moldawer, L.L.3
Edwards, C.K.4
Kim, H.J.5
Carter, J.L.6
-
34
-
-
34548732637
-
A placebo-controlled double blind trial of etanercept for the cancer anorexia/ weight loss syndrome: Results from N00C1 from the North Central Cancer Treatment Group
-
Jatoi A, Dakhil SR, Nguyen PL, Sloan JA, Kugler JW, Rowland KMJr, et al. A placebo-controlled double blind trial of etanercept for the cancer anorexia/ weight loss syndrome: results from N00C1 from the North Central Cancer Treatment Group. Cancer 2007;110:1396-403.
-
(2007)
Cancer
, vol.110
, pp. 1396-1403
-
-
Jatoi, A.1
Dakhil, S.R.2
Nguyen, P.L.3
Sloan, J.A.4
Kugler, J.W.5
Rowland, K.M.6
-
35
-
-
77950459905
-
A placebo-controlled, double-blind trial of infliximab for cancer-associated weight loss in elderly and/or poor performance non-small cell lung cancer patients (N01C9)
-
Jatoi A, Ritter HL, Dueck A, Nguyen PL, Nikcevich DA, Luyun RF, et al. A placebo-controlled, double-blind trial of infliximab for cancer-associated weight loss in elderly and/or poor performance non-small cell lung cancer patients (N01C9). Lung Cancer 2010;68:234-9.
-
(2010)
Lung Cancer
, vol.68
, pp. 234-239
-
-
Jatoi, A.1
Ritter, H.L.2
Dueck, A.3
Nguyen, P.L.4
Nikcevich, D.A.5
Luyun, R.F.6
-
36
-
-
38949086148
-
A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia
-
Wiedenmann B, Malfertheiner P, Friess H, Ritch P, Arseneau J, Mantovani G, et al. A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia. J Support Oncol 2008;6:18-25.
-
(2008)
J Support Oncol
, vol.6
, pp. 18-25
-
-
Wiedenmann, B.1
Malfertheiner, P.2
Friess, H.3
Ritch, P.4
Arseneau, J.5
Mantovani, G.6
-
37
-
-
84941342886
-
Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival
-
Johnston AJ, Murphy KT, Jenkinson L, Laine D, Emmrich K, Faou P, et al. Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival. Cell 2015;162:1365-78.
-
(2015)
Cell
, vol.162
, pp. 1365-1378
-
-
Johnston, A.J.1
Murphy, K.T.2
Jenkinson, L.3
Laine, D.4
Emmrich, K.5
Faou, P.6
-
38
-
-
84899989426
-
MABp1, a first-in-class true human antibody targeting interleukin-1alpha in refractory cancers: An open-label, phase 1 dose-escalation and expansion study
-
Hong DS, Hui D, Bruera E, Janku F, Naing A, Falchook GS, et al. MABp1, a first-in-class true human antibody targeting interleukin-1alpha in refractory cancers: an open-label, phase 1 dose-escalation and expansion study. Lancet Oncol 2014;15:656-66.
-
(2014)
Lancet Oncol
, vol.15
, pp. 656-666
-
-
Hong, D.S.1
Hui, D.2
Bruera, E.3
Janku, F.4
Naing, A.5
Falchook, G.S.6
-
39
-
-
84982184187
-
A phase III study of xilonix in refractory colorectal cancer patients with weight loss
-
suppl 3; abstr 685
-
Fisher GA. A phase III study of xilonix in refractory colorectal cancer patients with weight loss. J Clin Oncol 33, 2015(suppl 3; abstr 685).
-
(2015)
J Clin Oncol
, vol.33
-
-
Fisher, G.A.1
-
40
-
-
71649084751
-
A phase I, pharmacokinetic (PK), and preliminary efficacy assessment of ALD518, a humanized anti-IL-6 antibody, in patients with advanced cancer
-
suppl; abstr 3025
-
Clarke SJ, Smith JT, Gebbie C, Sweeney C, Olszewski N. A phase I, pharmacokinetic (PK), and preliminary efficacy assessment of ALD518, a humanized anti-IL-6 antibody, in patients with advanced cancer. J Clin Oncol 27:15s, 2009(suppl; abstr 3025).
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Clarke, S.J.1
Smith, J.T.2
Gebbie, C.3
Sweeney, C.4
Olszewski, N.5
-
41
-
-
78651506680
-
Effect of ALD518, a humanized anti-IL-6 antibody, on lean bodymass loss and symptoms in patients with advanced non-small cell lung cancer (NSCLC): Results of a phase II randomized, double-blind safety and efficacy trial
-
suppl; abstr 7622
-
Rigas JR, Schuster M, Orlov SV, Milovanovic B, Prabhash K, Smith JT, et al. Effect of ALD518, a humanized anti-IL-6 antibody, on lean bodymass loss and symptoms in patients with advanced non-small cell lung cancer (NSCLC): results of a phase II randomized, double-blind safety and efficacy trial. J Clin Oncol 28:15s, 2010(suppl; abstr 7622).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Rigas, J.R.1
Schuster, M.2
Orlov, S.V.3
Milovanovic, B.4
Prabhash, K.5
Smith, J.T.6
-
42
-
-
78651506680
-
ALD518, a humanized anti-IL-6 antibody, treats anemia in patients with advanced non-small cell lung cancer (NSCLC): Results of a phase II, randomized, double-blind, placebo-controlled trial
-
suppl; abstr 7631
-
Schuster M, Rigas JR, Orlov SV, Milovanovic B, Prabhash K, Smith JT, et al. ALD518, a humanized anti-IL-6 antibody, treats anemia in patients with advanced non-small cell lung cancer (NSCLC): results of a phase II, randomized, double-blind, placebo-controlled trial. J Clin Oncol 28:15s, 2010(suppl; abstr 7631).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Schuster, M.1
Rigas, J.R.2
Orlov, S.V.3
Milovanovic, B.4
Prabhash, K.5
Smith, J.T.6
-
43
-
-
84877673645
-
Bladder cancer-induced skeletal muscle wasting: Disclosing the role of mitochondria plasticity
-
Padrao AI, Oliveira P, Vitorino R, Colaco B, Pires MJ, Marquez M, et al. Bladder cancer-induced skeletal muscle wasting: disclosing the role of mitochondria plasticity. Int J Biochem Cell Biol 2013;45: 1399-409.
-
(2013)
Int J Biochem Cell Biol
, vol.45
, pp. 1399-1409
-
-
Padrao, A.I.1
Oliveira, P.2
Vitorino, R.3
Colaco, B.4
Pires, M.J.5
Marquez, M.6
-
44
-
-
84929359457
-
Role of activin A and myostatin in human cancer cachexia
-
Loumaye A, de Barsy M, Nachit M, Lause P, Frateur L, van Maanen A, et al. Role of activin A and myostatin in human cancer cachexia. J Clin Endocrinol Metab 2015;100:2030-8.
-
(2015)
J Clin Endocrinol Metab
, vol.100
, pp. 2030-2038
-
-
Loumaye, A.1
De Barsy, M.2
Nachit, M.3
Lause, P.4
Frateur, L.5
Van Maanen, A.6
-
45
-
-
84866527529
-
Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance
-
Busquets S, Toledo M, Orpi M, Massa D, Porta M, Capdevila E, et al. et al. Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance. J Cachexia Sarcopenia Muscle 2012;3:37-43.
-
(2012)
J Cachexia Sarcopenia Muscle
, vol.3
, pp. 37-43
-
-
Busquets, S.1
Toledo, M.2
Orpi, M.3
Massa, D.4
Porta, M.5
Capdevila, E.6
-
46
-
-
73949143033
-
Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia
-
Benny Klimek ME, Aydogdu T, Link MJ, Pons M, Koniaris LG, Zimmers TA. Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. Biochem Biophys Res Commun 2010;391:1548-54.
-
(2010)
Biochem Biophys Res Commun
, vol.391
, pp. 1548-1554
-
-
Benny Klimek, M.E.1
Aydogdu, T.2
Link, M.J.3
Pons, M.4
Koniaris, L.G.5
Zimmers, T.A.6
-
47
-
-
77955642517
-
Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival
-
Zhou X, Wang JL, Lu J, Song Y, Kwak KS, Jiao Q, et al. Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell 2010;142:531-43.
-
(2010)
Cell
, vol.142
, pp. 531-543
-
-
Zhou, X.1
Wang, J.L.2
Lu, J.3
Song, Y.4
Kwak, K.S.5
Jiao, Q.6
-
48
-
-
80052415879
-
Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice
-
Murphy KT, Chee A, Gleeson BG, Naim T, Swiderski K, Koopman R, et al. Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice. Am J Physiol Regul Integr Comp Physiol 2011;301:R716-26.
-
(2011)
Am J Physiol Regul Integr Comp Physiol
, vol.301
, pp. R716-R726
-
-
Murphy, K.T.1
Chee, A.2
Gleeson, B.G.3
Naim, T.4
Swiderski, K.5
Koopman, R.6
-
49
-
-
84887911950
-
Safety of the antimyostatin monoclonal antibody LY2495655 in healthy subjects and patients with advanced cancer
-
suppl; abstr 2516
-
Jameson GS, Von Hoff DD, Weiss GJ, Richards DA, Smith DA, Becerra C, et al. Safety of the antimyostatin monoclonal antibody LY2495655 in healthy subjects and patients with advanced cancer. J Clin Oncol 30, 2012 (suppl; abstr 2516).
-
(2012)
J Clin Oncol
, vol.30
-
-
Jameson, G.S.1
Von Hoff, D.D.2
Weiss, G.J.3
Richards, D.A.4
Smith, D.A.5
Becerra, C.6
-
50
-
-
84924156115
-
Treatment of sporadic inclusion body myositis with bimagrumab
-
Amato AA, Sivakumar K, Goyal N, David WS, Salajegheh M, Praestgaard J, et al. Treatment of sporadic inclusion body myositis with bimagrumab. Neurology 2014;83:2239-46.
-
(2014)
Neurology
, vol.83
, pp. 2239-2246
-
-
Amato, A.A.1
Sivakumar, K.2
Goyal, N.3
David, W.S.4
Salajegheh, M.5
Praestgaard, J.6
-
51
-
-
84862502202
-
Changes in myostatin signaling in non-weight-losing cancer patients
-
Aversa Z, Bonetto A, Penna F, Costelli P, Di Rienzo G, Lacitignola A, et al. et al.Changes in myostatin signaling in non-weight-losing cancer patients. Ann Surg Oncol 2012;19:1350-6.
-
(2012)
Ann Surg Oncol
, vol.19
, pp. 1350-1356
-
-
Aversa, Z.1
Bonetto, A.2
Penna, F.3
Costelli, P.4
Di Rienzo, G.5
Lacitignola, A.6
-
52
-
-
84918544121
-
Myostatin gene inactivation prevents skeletal muscle wasting in cancer
-
Gallot YS, Durieux AC, Castells J, Desgeorges MM, Vernus B, Plantureux L, et al. et al.Myostatin gene inactivation prevents skeletal muscle wasting in cancer. Cancer Res 2014;74:7344-56.
-
(2014)
Cancer Res
, vol.74
, pp. 7344-7356
-
-
Gallot, Y.S.1
Durieux, A.C.2
Castells, J.3
Desgeorges, M.M.4
Vernus, B.5
Plantureux, L.6
-
53
-
-
84958915621
-
Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and beta-2 agonist
-
Toledo M, Busquets S, Penna F, Zhou X, Marmonti E, Betancourt A, et al. Complete reversal of muscle wasting in experimental cancer cachexia: additive effects of activin type II receptor inhibition and beta-2 agonist. Int J Cancer 2016;138:2021-9.
-
(2016)
Int J Cancer
, vol.138
, pp. 2021-2029
-
-
Toledo, M.1
Busquets, S.2
Penna, F.3
Zhou, X.4
Marmonti, E.5
Betancourt, A.6
-
54
-
-
6044261233
-
TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions
-
Mori S, Matsuzaki K, Yoshida K, Furukawa F, Tahashi Y, Yamagata H, et al. TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions. Oncogene 2004;23: 7416-29.
-
(2004)
Oncogene
, vol.23
, pp. 7416-7429
-
-
Mori, S.1
Matsuzaki, K.2
Yoshida, K.3
Furukawa, F.4
Tahashi, Y.5
Yamagata, H.6
|