Astrocyte elevated gene-1 overexpression in hepatocellular carcinoma: An independent prognostic factor

Annals of Surgical Treatment and Research

Volumn 88, Issue 2, 2015, Pages 77-85

  Jung, Hae Il ^a   Ahn, Taesung ^a   Bae, Sang Ho ^a   Chung, Jun Chul ^a   Kim, Hyungjoo ^a   Chin, Susie ^a   Jeong, Dongjun ^a   Cho, Hyon Doek ^a   Lee, Moon Soo ^a   Kim, Hyung Chul ^a   Kim, Chang Ho ^a   Baek, Moo Jun ^a  

^a Soonchunhyang University   (South Korea)

Author keywords

Hepatocellular carcinoma; Human MTDH protein; Neoplasm metastasis

Indexed keywords

EID: 84982175008     PISSN: 22886575     EISSN: 22886796     Source Type: Journal    
DOI: 10.4174/astr.2015.88.2.77     Document Type: Article

References (29)

1. El-Serag HB. Hepatocellular carcinoma. N Engl JM ed 2011; 365:1118-27.
2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11-30.
3. Korea Central Cancer Registry. Cancer reference information [Internet]. Goyang: Korea Central Cancer Registry; c2012 [cited 2012 Dec 27]. Available from: http://www.cancer.go.kr.
4. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362: 1907-17.
5. Sarkar D. AEG-1/MTDH/LYRIC in liver cancer. Adv Cancer Res 2013; 120:193-221.
6. Britt DE, Yang DF, Yang D.Q., Flanagan D., Callanan H, Lim Y P, et al. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res 2004; 300:134-48.
7. Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W., Volsky DJ, et al. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 2002; 21:3592-602.
8. Hu G, Chong RA, Yang Q, Wei Y., Blanco MA, Li F, et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009; 15:9-20.
9. Sarkar D, Fisher PB AEG-1/MTDH/LYRIC: clinical significance. Adv Cancer Res 2013; 120:39-74.
10. Yoo BK, Emdad L, Su Z.Z., Villanueva A., Chiang DY, Mukhopadhyay ND, et al. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 2009; 119:465-77.
11. Lee SG, Su ZZ, Emdad L, Sarkar D., Fisher PB. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci U S A 2006; 103:17390-5.
12. Guo J, Xia B, Meng F., Lou G. miR-137 suppresses cell growth in ovarian cancer by targeting AEG-1. Biochem Biophys Res Commun 2013; 441:357-63.
13. Yang Y, Wu J, Guan H., Cai J, Fang L, Li J., et al. MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2. FEBS Lett 2012; 586:3608-12.
14. He XX, Chang Y, Meng F.Y., Wang MY, Xie QH, Tang F, et al MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene 2012; 31:3357-69.
15. Yoo BK, Emdad L, Lee S.G., Su ZZ, Santhekadur P, Chen D, et al Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacol Ther 2011; 130:1-8.
16. Ma J, Xie SL, Geng Y.J., Jin S., Wang GY, Lv GY. In vitro regulation of hepatocellular carcinoma cell viability, apoptosis, invasion, and AEG-1 expression by LY294002. Clin Res Hepatol Gastroenterol 2014; 38:73-80.
17. Li C, Chen K, Cai J., Shi QT, Li Y, Li L, et al Astrocyte elevated gene-1: a novel independent prognostic biomarker for metastatic ovarian tumors. Tumour Biol 2014; 35:3079-85.
18. Chen X, Dong K, Long M., Lin F, Wang X, Wei J., et al. Serum anti-AEG-1 auto-antibody is a potential novel biomarker for malignant tumors. Oncol Lett 2012; 4:319-23.
19. Jian-bo X., Hui W, Yu-long H, Chang-hua Z, Long-juan Z, Shi-rong C, et al. Astrocyte elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 2011; 28:455-62.
20. Song H, Li C, Li R., Geng J. Prognostic signi ficance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis 2010; 25:1201-9.
21. Deng H, Zhou Z, Tu W., Xia Y, Huang H, Tian D. Knockdown of astrocyte elevated gene-1 inhibits growth through suppression of IL-6 secretion in HepG2 human hepatoma cells. Oncol Lett 2014; 7:101-6.
22. Zheng J, Li C, Wu X., Yang Y, Hao M, Sheng S., et al. Astrocyte elevated gene-1 is a novel biomarker of epithelial-mesen-chymal transition and progression of hepatocellular carcinoma in two China regions. Tumour Biol 2014; 35:2265-9.
23. Zheng J, Li C, Wu X., Liu M, Sun X, Yang Y., et al. Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cellmediated immune response. Tumour Biol 2014; 35:4219-24.
24. Srivastava J, Siddiq A, Emdad L., Santhekadur PK, Chen D, Gredler R, et al Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology 2012; 56:1782-91.
25. Llovet JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999; 19:329-38.
26. Yoo BK, Gredler R, Vozhilla N., Su ZZ, Chen D, Forcier T, et al Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci U S A 2009; 106:12938-43.
27. Llovet JM, Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 2008; 48:1312-27.
28. Villanueva A, Llovet JM Targeted therapies for hepatocellular carcinoma. Gast Roenterology 2011; 140:1410-26.
29. Caron M, Choquet-Kastylevsky G, Joubert Caron R. Cancer immunomics using autoantibody signatures for bio marker discovery. Mol Cell Proteomics 2007; 6:1115-22.