Pathogenesis of Helicobacter pylori infection

Helicobacter

Volumn 21, Issue , 2016, Pages 19-25

  Backert, Steffen ^a   Neddermann, Matthias ^a   Maubach, Gunter ^b   Naumann, Michael ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

CagA; CagL; gastric cancer; gastroids; HtrA; inflammation; pathogenicity island; signaling; TlpB; type IV secretion system; urease; VacA

Indexed keywords

ABO GLYCAN; BABA PROTEIN; GLYCAN; HTRA PROTEIN; SERINE PROTEINASE; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

APOPTOSIS; BACTERIAL COLONIZATION; BACTERIAL OUTER MEMBRANE; CRYSTAL STRUCTURE; DNA DAMAGE; DNA METHYLATION; DNA POLYMORPHISM; EXOSOME; HELICOBACTER INFECTION; HUMAN; INFECTION CONTROL; INNATE IMMUNITY; INTESTINE FLORA; INTRACELLULAR SIGNALING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW; TYPE IV SECRETION SYSTEM;

EID: 84982091092     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/hel.12335     Document Type: Review

References (65)

1. Huang JY, Sweeney EG, Sigal M, et al. Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium. Cell Host Microbe. 2015;18:147–156.
2. Sigal M, Rothenberg ME, Logan CY, et al. Helicobacter pylori activates and expands Lgr5+ stem cells through direct colonization of the gastric glands. Gastroenterology. 2015;148:1392–1404. e21.
3. Müller SA, Pernitzsch SR, Haange S-B, et al. Stable isotope labeling by amino acids in cell culture based proteomics reveals differences in protein abundances between spiral and coccoid forms of the gastric pathogen Helicobacter pylori. J Proteomics. 2015;126:34–45.
4. De Bruyne E, Ducatelle R, Foss D, et al. Oral glutathione supplementation drastically reduces Helicobacter-induced gastric pathologies. Sci Rep. 2016;6:20169.
5. Hammond CE, Beeson C, Suarez G, Peek RM, Backert S, Smolka AJ. Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. Am J Physiol Gastrointest Liver Physiol. 2015;309:G193–G201.
6. Zhang L, Wu WK, Gallo RL, et al. Critical role of antimicrobial peptide cathelicidin for controlling Helicobacter pylori survival and infection. J Immunol. 2016;196:1799–1809.
7. Jung SW, Lee SW. The antibacterial effect of fatty acids on Helicobacter pylori infection. Korean J Intern Med. 2016;31:30.
8. Gaddy JA, Radin JN, Cullen TW, et al. Helicobacter pylori resists the antimicrobial activity of calprotectin via lipid A modification and associated biofilm formation. MBio. 2015;6:e01349-15.
9. Pachathundikandi SK, Lind J, Tegtmeyer N, El-Omar EM, Backert S. Interplay of the gastric pathogen Helicobacter pylori with toll-like receptors. Biomed Res Int. 2015;2015:192420.
10. Nagashima H, Iwatani S, Cruz M, et al. Toll-like receptor 10 in Helicobacter pylori infection. J Infect Dis. 2015;212:1666–1676.
11. Pachathundikandi SK, Backert S. Differential expression of IL-1β during Helicobacter pylori infection of TLR2- and TLR10-expressing HEK293 cell lines. J Infect Dis. 2016;214:166–167.
12. Obayashi N, Ohtsuka Y, Hosoi K, et al. Comparison of gene expression between pediatric and adult gastric mucosa with Helicobacter pylori infection. Helicobacter. 2016;21:114–123.
13. Kienesberger S, Cox LM, Livanos A, et al. Gastric Helicobacter pylori infection affects local and distant microbial populations and host responses. Cell Rep. 2016;14:1395–1407.
14. Gagnière J, Raisch J, Veziant J, et al. Gut microbiota imbalance and colorectal cancer. World J Gastroenterol. 2016;22:501–518.
15. Earle KA, Billings G, Sigal M, et al. Quantitative imaging of gut microbiota spatial organization. Cell Host Microbe. 2015;18:478–488.
16. Wang L, Zhou J, Xin Y, et al. Bacterial overgrowth and diversification of microbiota in gastric cancer. Eur J Gastroenterol Hepatol. 2016;28:261–266.
17. Schlaermann P, Toelle B, Berger H, et al. A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro. Gut. 2016;65:202–213.
18. Bartfeld S, Clevers H. Organoids as model for infectious diseases: culture of human and murine stomach organoids and microinjection of Helicobacter pylori. J Vis Exp. 2015;105:e53359-e.
19. Wroblewski LE, Piazuelo MB, Chaturvedi R, et al. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut. 2015;64:720–730.
20. Shimoda A, Ueda K, Nishiumi S, et al. Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA. Sci Rep. 2016;6:18346.
21. Turkina MV, Olofsson A, Magnusson K-E, Arnqvist A, Vikström E. Helicobacter pylori vesicles carrying CagA localize in the vicinity of cell–cell contacts and induce histone H1 binding to ATP in epithelial cells. FEMS Microbiol Lett. 2015;362:fnv076.
22. Grande R, Di Marcantonio MC, Robuffo I, et al. Helicobacter pylori ATCC 43629/NCTC 11639 outer membrane vesicles (OMVs) from biofilm and planktonic phase associated with extracellular DNA (eDNA). Front Microbiol. 2015;6:1369.
23. Hage N, Howard T, Phillips C, et al. Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA. Sci Adv. 2015;1:e1500315.
24. Moonens K, Gideonsson P, Subedi S, et al. Structural insights into polymorphic ABO glycan binding by Helicobacter pylori. Cell Host Microbe. 2016;19:55–66.
25. Frick-Cheng AE, Pyburn TM, Voss BJ, McDonald WH, Ohi MD, Cover TL. Molecular and structural analysis of the Helicobacter pylori cag type IV secretion system core complex. MBio. 2016;7:e02001-15.
26. Choi JM, Choi YH, Sudhanva MS, et al. Crystal structure of CagL from Helicobacter pylori K74 strain. Biochem Biophys Res Commun. 2015;460:964–970.
27. Bonsor AD, Pham KT, Beadenkopf R, et al. Integrin engagement by the helical RGD motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix. J Biol Chem. 2015;290:12929–12940.
28. Shariq M, Kumar N, Kumari R, Kumar A, Subbarao N, Mukhopadhyay G. Biochemical analysis of CagE: A VirB4 homologue of Helicobacter pylori Cag-T4SS. PLoS ONE. 2015;10:e0142606.
29. Kern B, Jain U, Utsch C, et al. Characterization of Helicobacter pylori VacA-containing vacuoles (VCVs), VacA intracellular trafficking and interference with calcium signalling in T lymphocytes. Cell Microbiol. 2015;17:1811–1832.
30. Amilon KR, Letley DP, Winter JA, Robinson K, Atherton JC. Expression of the Helicobacter pylori virulence factor vacuolating cytotoxin A (vacA) is influenced by a potential stem-loop structure in the 5′ untranslated region of the transcript. Mol Microbiol. 2015;98:831–846.
31. Chang H, Chen D, Ni B, et al. Cortactin mediates apoptosis of gastric epithelial cells induced by VacA protein of Helicobacter pylori. Dig Dis Sci. 2016;61:80–90.
32. Yahiro K, Hirayama T, Moss J, Noda M. Helicobacter pylori VacA toxin causes cell death by inducing accumulation of cytoplasmic connexin 43. Cell Death Dis. 2015;6:e1971.
33. Nakashima S, Kakugawa T, Yura H, et al. Identification of Helicobacter pylori VacA in human lung and its effects on lung cells. Biochem Biophys Res Commun. 2015;460:721–726.
34. Ferreira RM, Pinto-Ribeiro I, Wen X, et al. Helicobacter pylori cagA promoter region sequences influence CagA expression and interleukin 8 secretion. J Infect Dis. 2016;213:669–673.
35. Schindele R, Weiss E, Haas RH, Fischer W. Quantitative analysis of CagA type IV secretion by Helicobacter pylori reveals substrate recognition and translocation requirements. Mol Microbiol. 2015;100:188–203.
36. Lind J, Backert S, Hoffmann R, et al. Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East-Asian-type Helicobacter pylori strains. BMC Microbiol. 2016; (in press).
37. Schmidt TP, Perna AM, Fugmann T, et al. Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA. Sci Rep. 2016;6:23264.
38. Tegtmeyer N, Moodley Y, Yamaoka Y, et al. Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA. Mol Microbiol. 2016;99:925–944.
39. Perna AM, Rodrigues T, Schmidt TP, et al. Fragment-based de novo design reveals a small-molecule inhibitor of Helicobacter pylori HtrA. Angew Chem Int Ed Engl. 2015;54:10244–10248.
40. Mocellin S, Verdi D, Pooley KA, Nitti D. Genetic variation and gastric cancer risk: a field synopsis and meta-analysis. Gut. 2015;64:1209–1219.
41. Ying HY, Yu BW, Yang Z, et al. Interleukin-1B 31 C>T polymorphism combined with Helicobacter pylori-modified gastric cancer susceptibility: evidence from 37 studies. J Cell Mol Med. 2016;20:526–536.
42. Mayerle J, den Hoed CM, Schurmann C, et al. Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA. 2013;309:1912–1920.
43. Ravishankar Ram M, Goh KL, Leow AH, et al. Polymorphisms at locus 4p14 of toll-like receptors TLR-1 and TLR-10 confer susceptibility to gastric carcinoma in Helicobacter pylori infection. PLoS ONE. 2015;10:e0141865.
44. Tang FB, Li ZX, Wang YM, et al. Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric lesions in a high-risk Chinese population. Infect Gen Evol. 2015;31:263–269.
45. He C, Tu H, Sun L, et al. SNP interactions of Helicobacter pylori-related host genes PGC, PTPN11, IL1B, and TLR4 in susceptibility to gastric carcinogenesis. Oncotarget. 2015;6:19017–19026.
46. Koeppel M, Garcia-Alcalde F, Glowinski F, Schlaermann P, Meyer TF. Helicobacter pylori infection causes characteristic DNA damage patterns in human cells. Cell Rep. 2015;11:1703–1713.
47. Wang K, Yuen ST, Xu J, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet. 2014;46:573–582.
48. Hartung ML, Gruber DC, Koch KN, et al. H. pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote NF-kappa B target gene expression. Cell Rep. 2015;13:70–79.
49. Le May N, Fradin D, Iltis I, Bougnères P, Egly JM. XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes. Mol Cell. 2012;47:622–632.
50. Sokolova O, Maubach G, Naumann M. MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection. Biochim Biophys Acta. 2014;1843:715–724.
51. Maeda S, Yoshida H, Mitsuno Y, et al. Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori. Mol Pathol. 2002;55:286–293.
52. Rath S, Das L, Kokate SB, et al. Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells. FASEB J. 2015;29:796–806.
53. Yang Z, Xie C, Xu W, et al. Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway. Oncotarget. 2015;6:31916–31926.
54. Cheng AS, Li MS, Kang W, et al. Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology. 2013;144:122–133 e9.
55. Sepulveda JL, Gutierrez-Pajares JL, Luna A, et al. High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing. Mod Pathol. 2016;29:182–193.
56. Zhang BG, Hu L, Zang MD, et al. Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFkappaB pathway in gastric cancer development. Oncotarget. 2016;9788–9800.
57. Ling Z-Q, Ge M-H, Lu X-X, et al. Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma. Oncotarget. 2015;6:8210–8225.
58. Kosumi K, Baba Y, Ishimoto T, et al. Relationship between LINE-1 hypomethylation and Helicobacter pylori infection in gastric mucosae. Med Oncol. 2015;32:117.
59. Vidal AF, Cruz AMP, Magalhaes L, et al. hsa-miR-29c and hsa-miR-135b differential expression as potential biomarker of gastric carcinogenesis. World J Gastroenterol. 2016;22:2060–2070.
60. Fassan M, Saraggi D, Balsamo L, et al. Let-7c down-regulation in Helicobacter pylori-related gastric carcinogenesis. Oncotarget. 2016;7:4915.
61. Kong D, Piao YS, Yamashita S, et al. Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. Oncogene. 2012;31:3949–3960.
62. Zhao XD, Lu YY, Guo H, et al. MicroRNA-7/NF-κB signaling regulatory feedback circuit regulates gastric carcinogenesis. J Cell Biol. 2015;210:613–627.
63. Liu W, Song N, Yao H, Zhao L, Liu H, Li G. miR-221 and miR-222 simultaneously target RECK and regulate growth and invasion of gastric cancer cells. Med Sci Monit. 2015;21:2718
64. Iyer MK, Niknafs YS, Malik R, et al. The landscape of long noncoding RNAs in the human transcriptome. Nat Genet. 2015;47:199–208.
65. Zhu H, Wang Q, Yao Y, et al. Microarray analysis of Long non-coding RNA expression profiles in human gastric cells and tissues with Helicobacter pylori Infection. BMC Med Genomics. 2015;8:84.