H. pylori-Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-κB Target Gene Expression

Cell Reports

Volumn 13, Issue 1, 2015, Pages 70-79

  Hartung, Mara L ^a   Gruber, Dorothea C ^a   Koch, Katrin N ^a   Grüter, Livia ^a   Rehrauer, Hubert ^a   Tegtmeyer, Nicole ^b   Backert, Steffen ^b   Müller, Anne ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; ENDONUCLEASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; XPF PROTEIN; XPG PROTEIN; CHROMATIN; DNA BINDING PROTEIN; DNA EXCISION REPAIR PROTEIN ERCC-5; I KAPPA B; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 8; NF-KAPPAB INHIBITOR ALPHA; NUCLEAR PROTEIN; RELA PROTEIN, HUMAN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TYPE IV SECRETION SYSTEM; XERODERMA PIGMENTOSUM GROUP F PROTEIN;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA END JOINING REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; EXCISION REPAIR; GENE ACTIVATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE TARGETING; GENOME ANALYSIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN TRANSPORT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; TYPE IV SECRETION SYSTEM; CHEMISTRY; CHROMATIN; DOUBLE STRANDED DNA BREAK; EPITHELIUM CELL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANTIGENS, CD29; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATIN; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA-BINDING PROTEINS; ENDONUCLEASES; EPITHELIAL CELLS; HELICOBACTER PYLORI; HOST-PATHOGEN INTERACTIONS; HUMANS; I-KAPPA B PROTEINS; INHIBITOR OF APOPTOSIS PROTEINS; INTERLEUKIN-8; NF-KAPPA B; NUCLEAR PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TYPE IV SECRETION SYSTEMS;

EID: 84943267755     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.08.074     Document Type: Article

References (21)

1. Arnold I.C., Lee J.Y., Amieva M.R., Roers A., Flavell R.A., Sparwasser T., Müller A. Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 2011, 140:199-209.
2. Backert S., Tegtmeyer N., Fischer W. Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system. Future Microbiol. 2015, 10:955-965.
3. Barrozo R.M., Cooke C.L., Hansen L.M., Lam A.M., Gaddy J.A., Johnson E.M., Cariaga T.A., Suarez G., Peek R.M., Cover T.L., Solnick J.V. Functional plasticity in the type IV secretion system of Helicobacter pylori. PLoS Pathog. 2013, 9:e1003189.
4. Chang P.C., Wang C.J., You C.K., Kao M.C. Effects of a HP0859 (rfaD) knockout mutation on lipopolysaccharide structure of Helicobacter pylori 26695 and the bacterial adhesion on AGS cells. Biochem. Biophys. Res. Commun. 2011, 405:497-502.
5. Chumduri C., Gurumurthy R.K., Zadora P.K., Mi Y., Meyer T.F. Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response. Cell Host Microbe 2013, 13:746-758.
6. Fischer W., Püls J., Buhrdorf R., Gebert B., Odenbreit S., Haas R. Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol. Microbiol. 2001, 42:1337-1348.
7. Gorrell R.J., Guan J., Xin Y., Tafreshi M.A., Hutton M.L., McGuckin M.A., Ferrero R.L., Kwok T. A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system. Cell. Microbiol. 2013, 15:554-570.
8. Haffner M.C., Aryee M.J., Toubaji A., Esopi D.M., Albadine R., Gurel B., Isaacs W.B., Bova G.S., Liu W., Xu J., et al. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nat. Genet. 2010, 42:668-675.
9. Hanada K., Uchida T., Tsukamoto Y., Watada M., Yamaguchi N., Yamamoto K., Shiota S., Moriyama M., Graham D.Y., Yamaoka Y. Helicobacter pylori infection introduces DNA double-strand breaks in host cells. Infect. Immun. 2014, 82:4182-4189.
10. Jiménez-Soto L.F., Kutter S., Sewald X., Ertl C., Weiss E., Kapp U., Rohde M., Pirch T., Jung K., Retta S.F., et al. Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. PLoS Pathog. 2009, 5:e1000684.
11. Jinks-Robertson S., Bhagwat A.S. Transcription-associated mutagenesis. Annu. Rev. Genet. 2014, 48:341-359.
12. Kwok T., Zabler D., Urman S., Rohde M., Hartig R., Wessler S., Misselwitz R., Berger J., Sewald N., König W., Backert S. Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 2007, 449:862-866.
13. Le May N., Mota-Fernandes D., Vélez-Cruz R., Iltis I., Biard D., Egly J.M. NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack. Mol. Cell 2010, 38:54-66.
14. Le May N., Fradin D., Iltis I., Bougnères P., Egly J.M. XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes. Mol. Cell 2012, 47:622-632.
15. Matsumoto Y., Marusawa H., Kinoshita K., Endo Y., Kou T., Morisawa T., Azuma T., Okazaki I.M., Honjo T., Chiba T. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat. Med. 2007, 13:470-476.
16. Nougayrède J.P., Homburg S., Taieb F., Boury M., Brzuszkiewicz E., Gottschalk G., Buchrieser C., Hacker J., Dobrindt U., Oswald E. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 2006, 313:848-851.
17. Salama N.R., Shepherd B., Falkow S. Global transposon mutagenesis and essential gene analysis of Helicobacter pylori. J. Bacteriol. 2004, 186:7926-7935.
18. Samba-Louaka A., Pereira J.M., Nahori M.A., Villiers V., Deriano L., Hamon M.A., Cossart P. Listeria monocytogenes dampens the DNA damage response. PLoS Pathog. 2014, 10:e1004470.
19. Shaffer C.L., Gaddy J.A., Loh J.T., Johnson E.M., Hill S., Hennig E.E., McClain M.S., McDonald W.H., Cover T.L. Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog. 2011, 7:e1002237.
20. Toller I.M., Neelsen K.J., Steger M., Hartung M.L., Hottiger M.O., Stucki M., Kalali B., Gerhard M., Sartori A.A., Lopes M., Müller A. Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Proc. Natl. Acad. Sci. USA 2011, 108:14944-14949.
21. Van Antwerp D.J., Martin S.J., Kafri T., Green D.R., Verma I.M. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 1996, 274:787-789.