Helicobacter pylori activates and expands Lgr5+ stem cells through direct colonization of the gastric glands

Gastroenterology

Volumn 148, Issue 7, 2015, Pages 1392-1404.e21

  Sigal, Michael ^a,b,c   Rothenberg, Michael E ^a,b   Logan, Catriona Y ^b,d   Lee, Josephine Y ^b   Honaker, Ryan W ^a,b   Cooper, Rachel L ^a,b   Passarelli, Ben ^b   Camorlinga, Margarita ^e   Bouley, Donna M ^b   Alvarez, Guillermo ^e,f   Nusse, Roeland ^b,d   Torres, Javier ^e   Amieva, Manuel R ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^f Endobariatric Surgery   (Mexico)

Author keywords

CagA; Infection; Progenitor Cells; Proliferation

Indexed keywords

BIOLOGICAL MARKER; CAGA PROTEIN; G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; UNCLASSIFIED DRUG; VIRULENCE FACTOR; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI; LGR5 PROTEIN, HUMAN; LGR5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; BACTERIUM COLONY; BACTERIUM MUTANT; CELL ACTIVATION; CELL FUNCTION; CELL LINEAGE; CELL PROLIFERATION; CHEMOTAXIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GASTRIC STEM CELL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPLASIA; IMAGE RECONSTRUCTION; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; STEM CELL; STEM CELL EXPANSION; STOMACH ANTRUM; STOMACH EPITHELIUM; STOMACH GLAND; THREE DIMENSIONAL IMAGING; UPREGULATION; ANIMAL; C57BL MOUSE; CYTOPLASM; DISEASE MODEL; GASTRIC MUCOSA; GENETICS; GENOTYPE; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; IMMUNOLOGY; KINETICS; METABOLISM; MICROBIOLOGY; MUTATION; PATHOGENICITY; PATHOLOGY; PHENOTYPE; TISSUE CULTURE TECHNIQUE; TRANSGENIC MOUSE; VIRULENCE;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BIOMARKERS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; GASTRIC MUCOSA; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOST-PATHOGEN INTERACTIONS; HUMANS; HYPERPLASIA; KINETICS; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; ORGANOIDS; PHENOTYPE; RECEPTORS, G-PROTEIN-COUPLED; STEM CELLS; TISSUE CULTURE TECHNIQUES; VIRULENCE;

EID: 84929211886     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.02.049     Document Type: Article

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