Baicalein Attenuates Neurological Deficits and Preserves Blood–Brain Barrier Integrity in a Rat Model of Intracerebral Hemorrhage

Neurochemical Research

Volumn 41, Issue 11, 2016, Pages 3095-3102

  Chen, Min ^a,b   Lai, Lingfeng ^a   Li, Xifeng ^a   Zhang, Xin ^a   He, Xuying ^a   Liu, Wenchao ^a   Li, Ran ^a   Ke, Xunchang ^a   Fu, Chuanyi ^c   Huang, Zhiwei ^d   Duan, Chuanzhi ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

^c Department of Neurology   (China)

^d Liuzhou Worker Hospital   (China)

Author keywords

Baicalein; Blood brain barrier; Inducible nitric oxide synthase; Intracerebral hemorrhage; MAPKs; NF B

Indexed keywords

BAICALEIN; CASPASE 3; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; PROTEIN ZO1; TRANSCRIPTION FACTOR RELA; FLAVANONE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR CHANGE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN WATER; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG MECHANISM; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RAT MODEL; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; ANIMAL; CEREBRAL HEMORRHAGE; DISEASE MODEL; DRUG EFFECTS; METABOLISM; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; FLAVANONES; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; RATS, SPRAGUE-DAWLEY;

EID: 84982084212     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-016-2032-8     Document Type: Article

References (53)

1. Nakamura T, Kuroda Y, Yamashita S et al (2008) Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. Stroke 39(2):463–469
2. Xi G, Keep RF, Hoff JT (2006) Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 5(1):53–63
3. Wu J, Hua Y, Keep RF, Schallert T, Hoff JT, Xi G (2002) Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage. Brain Res 953(1–2):45–52
4. Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G (2005) Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res 1039(1–2):30–36
5. Shang H, Cui D, Yang D, Liang S, Zhang W, Zhao W (2015) The radical scavenger edaravone improves neurologic function and perihematomal glucose metabolism after acute intracerebral hemorrhage. J Stroke Cerebrovasc Dis 24(1):215–222
6. Chan PH (2001) Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 21(1):2–14
7. Hall CN, Reynell C, Gesslein B et al (2014) Capillary pericytes regulate cerebral blood flow in health and disease. Nature 508(7494):55–60
8. Armulik A, Genove G, Mae M et al (2010) Pericytes regulate the blood–brain barrier. Nature 468(7323):557–561
9. Lukic-Panin V, Deguchi K, Yamashita T et al (2010) Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage. Curr Neurovasc Res 7(4):319–329
10. Zlokovic BV (2008) The blood–brain barrier in health and chronic neurodegenerative disorders. Neuron 57(2):178–201
11. Bolton C, Wood EG, Scott GS, Flower RJ (2009) A comparative evaluation of the response to peroxynitrite by a brain endothelial cell line and control of the effects by drug targeting. Cell Mol Neurobiol 29(5):707–717
12. Torreilles F, Salman-Tabcheh S, Guerin M, Torreilles J (1999) Neurodegenerative disorders: the role of peroxynitrite. Brain Res Brain Res Rev 30(2):153–163
13. Knepler JJ, Taher LN, Gupta MP et al (2001) Peroxynitrite causes endothelial cell monolayer barrier dysfunction. Am J Physiol Cell Physiol 281(3):C1064–C1075
14. Bochorakova H, Paulova H, Slanina J, Musil P, Taborska E (2003) Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother Res 17(6):640–644
15. Zhang DY, Wu J, Ye F et al (2003) Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res 63(14):4037–4043
16. Liu B, Jian Z, Li Q et al (2012) Baicalein protects human melanocytes from H(2)O(2)-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway. Free Radic Biol Med 53(2):183–193
17. Shen YC, Chiou WF, Chou YC, Chen CF (2003) Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes. Eur J Pharmacol 465(1–2):171–181
18. Liu A, Huang L, Fan H et al (2015) Baicalein pretreatment protects against liver ischemia/reperfusion injury via inhibition of NF-kappaB pathway in mice. Int Immunopharmacol 24(1):72–79
19. Cui L, Zhang X, Yang R et al (2010) Baicalein is neuroprotective in rat MCAO model: role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2. Pharmacol Biochem Behav 96(4):469–475
20. Wang AW, Song L, Miao J et al (2015) Baicalein attenuates angiotensin II-induced cardiac remodeling via inhibition of AKT/mTOR, ERK1/2, NF-kappaB, and calcineurin signaling pathways in mice. Am J Hypertens 28(4):518–526
21. Zhang R, Liu Y, Yan K et al (2013) Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury. J Neuroinflammation 10:106
22. Rosenberg GA, Mun-Bryce S, Wesley M, Kornfeld M (1990) Collagenase-induced intracerebral hemorrhage in rats. Stroke 21(5):801–807
23. Shen LH, Li Y, Chen J et al (2007) One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke. Stroke 38(7):2150–2156
24. Chu K, Jeong SW, Jung KH et al (2004) Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. J Cereb Blood Flow Metab 24(8):926–933
25. Jung KH, Chu K, Jeong SW et al (2004) HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage. Stroke 35(7):1744–1749
26. Khan M, Sakakima H, Dhammu TS et al (2011) S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats. J Neuroinflammation 8:78
27. Zhong Z, Wang B, Dai M et al (2013) Carvacrol alleviates cerebral edema by modulating AQP4 expression after intracerebral hemorrhage in mice. Neurosci Lett 555:24–29
28. Yang S, Chen Y, Deng X et al (2013) Hemoglobin-induced nitric oxide synthase overexpression and nitric oxide production contribute to blood–brain barrier disruption in the rat. J Mol Neurosci 51(2):352–363
29. Lee EJ, Hung YC, Lee MY (1999) Early alterations in cerebral hemodynamics, brain metabolism, and blood–brain barrier permeability in experimental intracerebral hemorrhage. J Neurosurg 91(6):1013–1019
30. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH (2002) Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 33(8):2100–2104
31. Benchenane K, Berezowski V, Fernandez-Monreal M et al (2005) Oxygen glucose deprivation switches the transport of tPA across the blood–brain barrier from an LRP-dependent to an increased LRP-independent process. Stroke 36(5):1065–1070
32. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ (2010) Structure and function of the blood–brain barrier. Neurobiol Dis 37(1):13–25
33. Genovese T, Mazzon E, Esposito E et al (2007) Beneficial effects of FeTSPP, a peroxynitrite decomposition catalyst, in a mouse model of spinal cord injury. Free Radic Biol Med 43(5):763–780
34. Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87(1):315–424
35. Chang CC, Wang YH, Chern CM et al (2011) Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia. Toxicol Appl Pharmacol 257(1):137–147
36. Scott GS, Virag L, Szabo C, Hooper DC (2003) Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation. Glia 41(2):105–116
37. Scott GS, Szabo C, Hooper DC (2004) Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro. J Neurotrauma 21(9):1255–1263
38. Cross AH, Manning PT, Stern MK, Misko TP (1997) Evidence for the production of peroxynitrite in inflammatory CNS demyelination. J Neuroimmunol 80(1–2):121–130
39. Jack C, Antel J, Bruck W, Kuhlmann T (2007) Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosis. Glia 55(9):926–934
40. Ding R, Chen Y, Yang S et al (2014) Blood–brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation. Brain Res 1571:25–38
41. Moskowitz MA, Lo EH, Iadecola C (2010) The science of stroke: mechanisms in search of treatments. Neuron 67(2):181–198
42. Dominguez C, Delgado P, Vilches A et al (2010) Oxidative stress after thrombolysis-induced reperfusion in human stroke. Stroke 41(4):653–660
43. Adibhatla RM, Hatcher JF (2010) Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 12(1):125–169
44. Sahu BD, Mahesh KJ, Sistla R (2015) Baicalein, a bioflavonoid, prevents cisplatin-induced acute kidney injury by up-regulating antioxidant defenses and down-regulating the MAPKs and NF-kappaB pathways. PLoS One 10(7):e134139
45. Lee E, Park HR, Ji ST, Lee Y, Lee J (2014) Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson’s disease model by downregulating the activations of nuclear factor-kappaB, ERK, and JNK. J Neurosci Res 92(1):130–139
46. He X, Wei Z, Zhou E et al (2015) Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-kappaB and MAPK signaling pathways in LPS-induced mastitis in mice. Int Immunopharmacol 28(1):470–476
47. Bowie A, O’Neill LA (2000) Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59(1):13–23
48. Wu HJ, Yiu WH, Li RX et al (2014) Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis. PLoS One 9(3):e90883
49. Liu Y, Zhang R, Yan K et al (2014) Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6. J Neuroinflammation 11:135
50. Wang W, Zhou PH, Xu CG, Zhou XJ, Hu W, Zhang J (2015) Baicalein attenuates renal fibrosis by inhibiting inflammation via down-regulating NF-kappaB and MAPK signal pathways. J Mol Histol 46(3):283–290
51. Chen SF, Hsu CW, Huang WH, Wang JY (2008) Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury. Br J Pharmacol 155(8):1279–1296
52. Hwang KY, Oh YT, Yoon H et al (2008) Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells. Neurosci Lett 444(3):264–269
53. Liu C, Wu J, Xu K et al (2010) Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochem 112(6):1500–1512