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Volumn 11, Issue 8, 2016, Pages 1357-1362

Axl receptor axis: A new therapeutic target in lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ASLAN 002; AXL RECEPTOR; BGB 324; BPI 9016; CABOZANTINIB; CRIZOTINIB; ERLOTINIB; FORETINIB; MGCD 265; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SITRAVATINIB; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; AXL RECEPTOR TYROSINE KINASE; ONCOPROTEIN; PROTEIN KINASE INHIBITOR;

EID: 84982083046     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1016/j.jtho.2016.04.015     Document Type: Article
Times cited : (35)

References (36)
  • 1
    • 84896786643 scopus 로고    scopus 로고
    • An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo
    • Subramanian M, Hayes CD, Thome JJ, et al. An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. J Clin Invest. 2014;124:1296-1308.
    • (2014) J Clin Invest , vol.124 , pp. 1296-1308
    • Subramanian, M.1    Hayes, C.D.2    Thome, J.J.3
  • 2
    • 77958559483 scopus 로고    scopus 로고
    • Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization
    • Cosemans JM, Van Kruchten R, Olieslagers S, et al. Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J Thromb Haemost. 2010;8: 1797-1808.
    • (2010) J Thromb Haemost , vol.8 , pp. 1797-1808
    • Cosemans, J.M.1    Van Kruchten, R.2    Olieslagers, S.3
  • 3
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • Lemke G, Rothlin CV. Immunobiology of the TAM receptors. Nat Rev Immunol. 2008;8:327-336.
    • (2008) Nat Rev Immunol , vol.8 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 4
    • 84928015512 scopus 로고    scopus 로고
    • AXL mediates resistance to PI3Kalpha inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas
    • Elkabets M, Pazarentzos E, Juric D, et al. AXL mediates resistance to PI3Kalpha inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas. Cancer Cell. 2015;27: 533-546.
    • (2015) Cancer Cell , vol.27 , pp. 533-546
    • Elkabets, M.1    Pazarentzos, E.2    Juric, D.3
  • 5
    • 0028878702 scopus 로고
    • The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding
    • Bellosta P, Costa M, Lin DA, Basilico C. The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding. Mol Cell Biol. 1995;15:614-625.
    • (1995) Mol Cell Biol , vol.15 , pp. 614-625
    • Bellosta, P.1    Costa, M.2    Lin, D.A.3    Basilico, C.4
  • 6
    • 0032543712 scopus 로고    scopus 로고
    • Determinants for transformation induced by the Axl receptor tyrosine kinase
    • Burchert A, Attar EC, McCloskey P, Fridell YW, Liu ET. Determinants for transformation induced by the Axl receptor tyrosine kinase. Oncogene. 1998;16:3177-3187.
    • (1998) Oncogene , vol.16 , pp. 3177-3187
    • Burchert, A.1    Attar, E.C.2    McCloskey, P.3    Fridell, Y.W.4    Liu, E.T.5
  • 7
    • 84872946587 scopus 로고    scopus 로고
    • YES-associated protein 1 promotes adenocarcinoma growth and metastasis through activation of the receptor tyrosine kinase Axl
    • Cui ZL, Han FF, Peng XH, et al. YES-associated protein 1 promotes adenocarcinoma growth and metastasis through activation of the receptor tyrosine kinase Axl. Int J Immunopathol Pharmacol. 2012;25:989-1001.
    • (2012) Int J Immunopathol Pharmacol , vol.25 , pp. 989-1001
    • Cui, Z.L.1    Han, F.F.2    Peng, X.H.3
  • 8
    • 79959673368 scopus 로고    scopus 로고
    • Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer
    • Mudduluru G, Ceppi P, Kumarswamy R, Scagliotti GV, Papotti M, Allgayer H. Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer. Oncogene. 2011;30:2888-2899.
    • (2011) Oncogene , vol.30 , pp. 2888-2899
    • Mudduluru, G.1    Ceppi, P.2    Kumarswamy, R.3    Scagliotti, G.V.4    Papotti, M.5    Allgayer, H.6
  • 9
    • 84875509079 scopus 로고    scopus 로고
    • Gain-of-function activity of mutant p53 in lung cancer through upregulation of receptor protein tyrosine kinase Axl
    • Vaughan CA, Singh S, Windle B, et al. Gain-of-function activity of mutant p53 in lung cancer through upregulation of receptor protein tyrosine kinase Axl. Genes Cancer. 2012;3:491-502.
    • (2012) Genes Cancer , vol.3 , pp. 491-502
    • Vaughan, C.A.1    Singh, S.2    Windle, B.3
  • 10
    • 84924956411 scopus 로고    scopus 로고
    • AUY922 effectively overcomes MET-and AXL-mediated resistance to EGFR-TKI in lung cancer cells
    • Choi YJ, Kim SY, So KS, et al. AUY922 effectively overcomes MET-and AXL-mediated resistance to EGFR-TKI in lung cancer cells. PLoS One. 2015;10:e0119832.
    • (2015) PLoS One , vol.10 , pp. e0119832
    • Choi, Y.J.1    Kim, S.Y.2    So, K.S.3
  • 11
    • 84982085906 scopus 로고    scopus 로고
    • Evaluation of the MET/AXL receptor tyrosine kinase (RTK) inhibitor MGCD265 in a patient with metastatic non-small cell lung cancer (NSCLC) harboring AXL amplification
    • Paper presented at September 6-9, 2015; Denver, CO
    • Do KT, MacConaill L, Dubuc A, et al. Evaluation of the MET/AXL receptor tyrosine kinase (RTK) inhibitor MGCD265 in a patient with metastatic non-small cell lung cancer (NSCLC) harboring AXL amplification. Paper presented at: 16th World Conference on Lung Cancer. September 6-9, 2015; Denver, CO.
    • 16th World Conference on Lung Cancer
    • Do, K.T.1    MacConaill, L.2    Dubuc, A.3
  • 12
    • 84943411277 scopus 로고    scopus 로고
    • AXL is an oncotarget in human colorectal cancer
    • Martinelli E, Martini G, Cardone C, et al. AXL is an oncotarget in human colorectal cancer. Oncotarget. 2015;6:23281-23296.
    • (2015) Oncotarget , vol.6 , pp. 23281-23296
    • Martinelli, E.1    Martini, G.2    Cardone, C.3
  • 13
    • 84868309107 scopus 로고    scopus 로고
    • The transcriptional landscape and mutational profile of lung adenocarcinoma
    • Seo JS, Ju YS, Lee WC, et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res. 2012;22:2109-2119.
    • (2012) Genome Res , vol.22 , pp. 2109-2119
    • Seo, J.S.1    Ju, Y.S.2    Lee, W.C.3
  • 14
    • 84922481128 scopus 로고    scopus 로고
    • The TAM family: Phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer
    • Graham DK, DeRyckere D, Davies KD, Earp HS. The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer. Nat Rev Cancer. 2014;14: 769-785.
    • (2014) Nat Rev Cancer , vol.14 , pp. 769-785
    • Graham, D.K.1    DeRyckere, D.2    Davies, K.D.3    Earp, H.S.4
  • 15
    • 84938406332 scopus 로고    scopus 로고
    • The AXL Receptor is a sensor of ligand spatial heterogeneity
    • Meyer AS, Zweemer AJ, Lauffenburger DA. The AXL Receptor is a sensor of ligand spatial heterogeneity. Cell Syst. 2015;1:25-36.
    • (2015) Cell Syst , vol.1 , pp. 25-36
    • Meyer, A.S.1    Zweemer, A.J.2    Lauffenburger, D.A.3
  • 16
    • 0030802887 scopus 로고    scopus 로고
    • Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts
    • Goruppi S, Ruaro E, Varnum B, Schneider C. Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts. Mol Cell Biol. 1997;17:4442-4453.
    • (1997) Mol Cell Biol , vol.17 , pp. 4442-4453
    • Goruppi, S.1    Ruaro, E.2    Varnum, B.3    Schneider, C.4
  • 17
    • 0029655520 scopus 로고    scopus 로고
    • Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase
    • Fridell YW, Jin Y, Quilliam LA, et al. Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase. Mol Cell Biol. 1996;16:135-145.
    • (1996) Mol Cell Biol , vol.16 , pp. 135-145
    • Fridell, Y.W.1    Jin, Y.2    Quilliam, L.A.3
  • 18
    • 84920019803 scopus 로고    scopus 로고
    • Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion
    • Abu-Thuraia A, Gauthier R, Chidiac R, et al. Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion. Mol Cell Biol. 2015;35:76-87.
    • (2015) Mol Cell Biol , vol.35 , pp. 76-87
    • Abu-Thuraia, A.1    Gauthier, R.2    Chidiac, R.3
  • 19
    • 0026010027 scopus 로고
    • Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
    • O'Bryan JP, Frye RA, Cogswell PC, et al. Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991;11:5016-5031.
    • (1991) Mol Cell Biol , vol.11 , pp. 5016-5031
    • O'Bryan, J.P.1    Frye, R.A.2    Cogswell, P.C.3
  • 20
    • 84871998076 scopus 로고    scopus 로고
    • An epithelialmesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
    • Byers LA, Diao L, Wang J, et al. An epithelialmesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res. 2013;19:279-290.
    • (2013) Clin Cancer Res , vol.19 , pp. 279-290
    • Byers, L.A.1    Diao, L.2    Wang, J.3
  • 21
  • 22
    • 75749115996 scopus 로고    scopus 로고
    • Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival
    • Gjerdrum C, Tiron C, Hoiby T, et al. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci U S A. 2010;107:1124-1129.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1124-1129
    • Gjerdrum, C.1    Tiron, C.2    Hoiby, T.3
  • 23
    • 84912101447 scopus 로고    scopus 로고
    • The role of Axl in drug resistance and epithelial-to-mesenchymal transition of non-small cell lung carcinoma
    • Wu F, Li J, Jang C, Wang J, Xiong J. The role of Axl in drug resistance and epithelial-to-mesenchymal transition of non-small cell lung carcinoma. Int J Clin Exp Pathol. 2014;7:6653-6661.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 6653-6661
    • Wu, F.1    Li, J.2    Jang, C.3    Wang, J.4    Xiong, J.5
  • 24
    • 84907546631 scopus 로고    scopus 로고
    • AXL mediates resistance to cetuximab therapy
    • Brand TM, Iida M, Stein AP, et al. AXL mediates resistance to cetuximab therapy. Cancer Res. 2014;74:5152-5164.
    • (2014) Cancer Res , vol.74 , pp. 5152-5164
    • Brand, T.M.1    Iida, M.2    Stein, A.P.3
  • 25
    • 84941965392 scopus 로고    scopus 로고
    • AXL Is a logical molecular target in head and neck squamous cell carcinoma
    • Brand TM, Iida M, Stein AP, et al. AXL Is a logical molecular target in head and neck squamous cell carcinoma. Clin Cancer Res. 2015;21:2601-2612.
    • (2015) Clin Cancer Res , vol.21 , pp. 2601-2612
    • Brand, T.M.1    Iida, M.2    Stein, A.P.3
  • 26
    • 84908136008 scopus 로고    scopus 로고
    • AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs
    • Wilson C, Ye X, Pham T, et al. AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs. Cancer Res. 2014;74:5878-5890.
    • (2014) Cancer Res , vol.74 , pp. 5878-5890
    • Wilson, C.1    Ye, X.2    Pham, T.3
  • 27
    • 70349705633 scopus 로고    scopus 로고
    • Axl as a potential therapeutic target in cancer: Role of Axl in tumor growth, metastasis and angiogenesis
    • Li Y, Ye X, Tan C, et al. Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis. Oncogene. 2009;28: 3442-3455.
    • (2009) Oncogene , vol.28 , pp. 3442-3455
    • Li, Y.1    Ye, X.2    Tan, C.3
  • 28
    • 33644876133 scopus 로고    scopus 로고
    • Expression of axl in lung adenocarcinoma and correlation with tumor progression
    • Shieh YS, Lai CY, Kao YR, et al. Expression of axl in lung adenocarcinoma and correlation with tumor progression. Neoplasia. 2005;7:1058-1064.
    • (2005) Neoplasia , vol.7 , pp. 1058-1064
    • Shieh, Y.S.1    Lai, C.Y.2    Kao, Y.R.3
  • 29
    • 84892819211 scopus 로고    scopus 로고
    • Higher expression of receptor tyrosine kinase Axl, and differential expression of its ligand, Gas6, predict poor survival in lung adenocarcinoma patients
    • Ishikawa M, Sonobe M, Nakayama E, et al. Higher expression of receptor tyrosine kinase Axl, and differential expression of its ligand, Gas6, predict poor survival in lung adenocarcinoma patients. Ann Surg Oncol. 2013;20(suppl 3):S467-S476.
    • (2013) Ann Surg Oncol , vol.20 , pp. S467-S476
    • Ishikawa, M.1    Sonobe, M.2    Nakayama, E.3
  • 30
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • Zhang Z, Lee JC, Lin L, et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet. 2012;44:852-860.
    • (2012) Nat Genet , vol.44 , pp. 852-860
    • Zhang, Z.1    Lee, J.C.2    Lin, L.3
  • 31
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3, 75ra26.
    • (2011) Sci Transl Med , vol.3 , pp. 75ra26
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 32
    • 84897954522 scopus 로고    scopus 로고
    • The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
    • Paolino M, Choidas A, Wallner S, et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014;507:508-512.
    • (2014) Nature , vol.507 , pp. 508-512
    • Paolino, M.1    Choidas, A.2    Wallner, S.3
  • 33
    • 84966731058 scopus 로고    scopus 로고
    • AXL inhibitors in cancer: A medicinal chemistry perspective
    • Myers SH, Brunton VG, Unciti-Broceta A. AXL inhibitors in cancer: a medicinal chemistry perspective. J Med Chem. 2015;59:3593-3608.
    • (2015) J Med Chem , vol.59 , pp. 3593-3608
    • Myers, S.H.1    Brunton, V.G.2    Unciti-Broceta, A.3
  • 34
    • 77957109253 scopus 로고    scopus 로고
    • An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
    • Ye X, Li Y, Stawicki S, et al. An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies. Oncogene. 2010;29:5254-5264.
    • (2010) Oncogene , vol.29 , pp. 5254-5264
    • Ye, X.1    Li, Y.2    Stawicki, S.3
  • 35
    • 84870615894 scopus 로고    scopus 로고
    • Targeting Axl with an high-affinity inhibitory aptamer
    • Cerchia L, Esposito CL, Camorani S, et al. Targeting Axl with an high-affinity inhibitory aptamer. Mol Ther. 2012;20:2291-2303.
    • (2012) Mol Ther , vol.20 , pp. 2291-2303
    • Cerchia, L.1    Esposito, C.L.2    Camorani, S.3
  • 36
    • 84942940565 scopus 로고    scopus 로고
    • Warfarin blocks Gas6-mediated Axl activation required for pancreatic cancer epithelial plasticity and metastasis
    • Kirane A, Ludwig KF, Sorrelle N, et al. Warfarin blocks Gas6-mediated Axl activation required for pancreatic cancer epithelial plasticity and metastasis. Cancer Res. 2015;75:3699-3705.
    • (2015) Cancer Res , vol.75 , pp. 3699-3705
    • Kirane, A.1    Ludwig, K.F.2    Sorrelle, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.