Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

Nature Communications

Volumn 7, Issue , 2016, Pages

  Gerling, Marco ^a   Büller, Nikè V J A ^b   Kirn, Leonard M ^a,c   Joost, Simon ^a   Frings, Oliver ^a   Englert, Benjamin ^a,c   Bergström, Åsa ^a   Kuiper, Raoul V ^a   Blaas, Leander ^a   Wielenga, Mattheus C B ^b   Almer, Sven ^a,d   Kühl, Anja A ^c   Fredlund, Erik ^a   Van Den Brink, Gijs R ^b   Toftgård, Rune ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 5; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 2; DESMIN; GROWTH DIFFERENTIATION FACTOR 10; NOGGIN; PROTEIN PATCHED 1; PROTEIN PATCHED 2; SONIC HEDGEHOG PROTEIN; TOSYLARGININE METHYL ESTER; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG; VIMENTIN; VISMODEGIB; AZOXYMETHANE; CRE RECOMBINASE; DEXTRAN SULFATE; INTEGRASE;

CANCER; CELLS AND CELL COMPONENTS; LIGAND; PROTEIN; SMALL MAMMAL; TUMOR;

ALLELE; ANIMAL CELL; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL DIFFERENTIATION; COLITIS; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GENE EXPRESSION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINAL STEM CELL; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; SIGNAL TRANSDUCTION; STROMA CELL; TERMINAL ILEUM; TUMOR VOLUME; UPREGULATION; WNT SIGNALING PATHWAY; ADENOCARCINOMA; ANIMAL; C57BL MOUSE; CELL PROLIFERATION; COLON; COLON TUMOR; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PATHOLOGY;

ERINACEIDAE; MUS;

ADENOCARCINOMA; ANIMALS; AZOXYMETHANE; BONE MORPHOGENETIC PROTEINS; CARCINOGENESIS; CELL PROLIFERATION; COLON; COLONIC NEOPLASMS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; INTEGRASES; MICE, INBRED C57BL; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION; STROMAL CELLS; TRANSCRIPTION, GENETIC; TUMOR BURDEN;

EID: 84981249348     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12321     Document Type: Article

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