Correlation of CpG island methylation of the cytochrome P450 2E1/2D6 genes with liver injury induced by anti-tuberculosis drugs: A nested case-control study

International Journal of Environmental Research and Public Health

Volumn 13, Issue 8, 2016, Pages

  Zhang, Jinling ^a   Zhu, Xuebin ^a   Li, Yuhong ^a   Zhu, Lingyan ^a   Li, Shiming ^b   Zheng, Guoying ^a   Ren, Qi ^a   Xiao, Yonghong ^a   Feng, Fumin ^a  

^a NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Department of Respiratory Medicine   (China)

Author keywords

Anti TB drug induced liver injury; Case control study; Cytochrome P450 2D6; Cytochrome P450 2E1; Methylation; Tuberculosis

Indexed keywords

CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; ETHAMBUTOL; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT;

CORRELATION; CYTOCHROME; DISEASE TREATMENT; DRUG; GENETIC ANALYSIS; GENOME; INJURY; METHYLATION; TUBERCULOSIS;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATIONAL STUDY; CPG ISLAND; CYP2D6 GENE; CYP2E1 GENE; DNA METHYLATION; DNA POLYMORPHISM; EPIGENETICS; FEMALE; FOLLOW UP; GENOTYPE; HUMAN; LIVER INJURY; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; PATIENT RISK; ASIAN CONTINENTAL ANCESTRY GROUP; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; METHYLATION; MIDDLE AGED; ODDS RATIO; RISK; TOXIC HEPATITIS; TUBERCULOSIS; YOUNG ADULT;

CHINA;

ADULT; AGED; ANTITUBERCULAR AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHEMICAL AND DRUG INDUCED LIVER INJURY; CPG ISLANDS; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP2E1; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; METHYLATION; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; RISK; TUBERCULOSIS; YOUNG ADULT;

EID: 84980322302     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph13080776     Document Type: Article

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