Methylation of the glutathione-S-transferase M3 gene promoter is associated with oxidative stress in acute-on-chronic hepatitis B liver failure

Tohoku Journal of Experimental Medicine

Volumn 228, Issue 1, 2012, Pages 43-51

  Qi, Li ^a,b   Zou, Zhi Qiang ^c   Wang, Li Yuan ^a   Gao, Shuai ^a   Fan, Yu Chen ^a,b   Long, Bo ^c   Guo, Yan Mei ^c   Xu, Ai Ling ^c   Han, Jie ^a   Li, Tao ^a   Wang, Kai ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c Yantai Infectious Disease Hospital   (China)

Author keywords

Acute on chronic hepatitis B Liver failure; Glutathione S transferase; Malondialdehyde; Oxidative stress; Promoter methylation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GLUTATHIONE TRANSFERASE M3; MALONALDEHYDE; VIRUS DNA;

ACUTE ON CHRONIC HEPATITIS B LIVER FAILURE; ACUTE ON CHRONIC LIVER FAILURE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA METHYLATION; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE DOSAGE; GLUTATHIONE TRANSFERASE M3 GENE; HUMAN; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; METHYLATION SPECIFIC POLYMERASE CHAIN REACTION; MODEL FOR END STAGE LIVER DISEASE SCORE; MORTALITY; OXIDATIVE STRESS; PREDICTIVE VALUE; PROGNOSIS; PROMOTER REGION; PROTHROMBIN TIME; SCORING SYSTEM;

DNA METHYLATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUTATHIONE TRANSFERASE; HEPATITIS B, CHRONIC; HUMANS; LIVER FAILURE, ACUTE; MALONDIALDEHYDE; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC;

EID: 84867874615     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.228.43     Document Type: Article

References (44)

1. Acar, A., Görenek, L., Aydin, A., Eyigün, C.P., Eken, A., Sayal, A. & Pahsa, A. (2009) Investigation of oxidative stress and antioxidant defense in patients with hepatitis B virus infection and the effect of interferon-alpha plus lamivudine combination therapy on oxidative stress. Mikrobiyol. Bul., 43, 411-423.
2. Armstrong, R.N. (1997) Structure, catalytic mechanism, and evolution of the glutathione transferases. Chem. Res. Toxicol., 10, 2-18.
3. Arslan, M., Kurtipek, O., Dogan, A.T., Unal, Y., Kizil, Y., Nurlu, N., Kamaci, S. & Kavutcu, M. (2009) Comparison of effects of anaesthesia with desfurane and enfurane on liver function. Singapore Med. J., 50, 73-77.
4. Bolukbas, C., Bolukbas, F.F., Horoz, M., Aslan, M., Celik, H. & Erel, O. (2005) Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect. Dis., 5, 95-102.
5. Chinese Society of Infectious Diseases and Parasitology & the Chinese Society of Hepatology of the Chinese Medical Association (2000) Management scheme of diagnostic and therapy criteria of viral hepatitis. Chin. J. Hepatol., 8, 324-329.
6. Choi, J. & Ou, J.H. (2006) Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am. J. Physiol. Gastrointest. Liver Physiol., 290, G847-851.
7. Clement, G., Braunschweig, R., Pasquier, N., Bosman, F.T. & Benhattar, J. (2006) Methylation of APC, TIMP3, and TERT: a new predictive marker to distinguish Barrett's oesophagus patients at risk for malignant transformation. J. Pathol., 208, 100-107.
8. Dröge, W. (2003) Oxidative stress and aging. Adv. Exp. Med. Biol., 543, 191-200.
9. Eads, C.A., Lord, R.V., Wickramasinghe, K., Long, T.I., Kurumboor, S.K., Bernstein, L., Peters, J.H., DeMeester, S.R., DeMeester, T.R., Skinner, K.A. & Laird, P.W. (2001) Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res., 61, 3410-3418.
10. Esteller, M., Corn, P.G., Baylin, S.B. & Herman, J.G. (2001) A gene hypermethylation profile of human cancer. Cancer Res., 61, 3225-3229.
11. Ha, H.L., Shin, H.J., Feitelson, M.A. & Yu, D.Y. (2010) Oxidative stress and antioxidants in hepatic pathogenesis. World J. Gastroenterol., 16, 6035-6043.
12. Hagen, T.M., Huang, S., Curnutte, J., Fowler, P., Martinez, V., Wehr, C.M., Ames, B.N. & Chisari, F.V. (1994) Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA, 91, 12808-12812.
13. Hayes, J.D., Flanagan, J.U. & Jowsey, I.R. (2005) Glutathione transferases. Annu. Rev. Pharmacol. Toxicol., 45, 51-88.
14. Hayes, J.D. & McLellan, L.I. (1999) Glutathione and glutathionedependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic. Res., 31, 273-300.
15. Hayes, J.D. & Pulford, D.J. (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol., 30, 445-600.
16. Hopkins, T.G., Burns, P.A. & Routledge, M.N. (2007) DNA methylation of GSTP1 as biomarker in diagnosis of prostate cancer. Urology, 69, 11-16.
17. Inskip, A., Elexperu-Camiruaga, J., Buxton, N., Dias, P.S., MacIntosh, J., Campbell, D., Jones, P.W., Yengi, L., Talbot, J.A., Strange, R.C. & Fryer, A.A. (1995) Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A. Biochem. J., 312, 713-716.
18. Jackson, A.L. & Loeb, L.A. (2001) The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat. Res., 477, 7-21.
19. Jung, J.K., Arora, P., Pagano, J.S. & Jang, K.L. (2007) Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway. Cancer Res., 67, 5771-5778.
20. Kamath, P.S., Wiesner, R.H., Malinchoc, M., Kremers, W., Therneau, T.M., Kosberg, C.L., D'Amico, G., Dickson, E.R. & Kim, W.R. (2001) A model to predict survival in patients with end-stage liver disease. Hepatology, 33, 464-470.
21. Ladero, J.M., Martínez, C., Fernández, J.M., Martín, F., García-Martín, E., Ropero, P., Villegas, A., Díaz-Rubio, M. & Agúndez, J.A. (2007) Glutathione S-transferases pi 1, alpha 1 and M3 genetic polymorphisms and the risk of hepatocellular carcinoma in humans. Pharmacogenomics, 8, 895-899.
22. Lee, J.O., Kwun, H.J., Jung, J.K., Choi, K.H., Min, D.S. & Jang, K.L. (2005) Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene, 24, 6617-6625.
23. Li, T., Meng, Q.H., Zou, Z.Q., Fan, Y.C., Long, B., Guo, Y.M., Hou, W., Zhao, J., Li, J., Yu, H.W., Zhu, Y.K. & Wang, K. (2011) Correlation between promoter methylation of glutathione-S-tranferase P1 and oxidative stress in acute-on-chronic hepatitis B liver failure. J. Viral. Hepat., 18, e226-231.
24. Liver Failure and Artificial Liver Group., Chinese Society of Infectious Diseases., Chinese Medical Association. & Severe Liver Diseases and Artificial Liver Group., Chinese Society of Hepatology., Chinese Medical Association. (2006) Diagnostic and treatment guidelines for liver failure. Chin. J. Hepatol., 14, 321-324.
25. Loft, S. & Poulsen, H.E. (1996) Cancer risk and oxidative DNA damage in man. J. Mol. Med., 74, 297-312.
26. McClune, A.C. & Tong, M.J. (2010) Chronic hepatitis B and hepatocellular carcinoma. Clin. Liver Dis., 14, 461-476.
27. Medeiros, R., Vasconcelos, A., Costa, S., Pinto, D., Ferreira, P., Lobo, F., Morais, A., Oliveira, J. & Lopes, C. (2004) Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms. Prostate, 58, 414-420.
28. Nair, J., Srivatanakul, P., Haas, C., Jedpiyawongse, A., Khuhaprema, T., Seitz, H.K. & Bartsch, H. (2010) High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases. Mutat. Res., 683, 23-28.
29. Palmisano, W.A., Divine, K.K., Saccomanno, G., Gilliland, F.D., Baylin, S.B., Herman, J.G. & Belinsky, S.A. (2000) Predicting Lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res., 60, 5954-5958.
30. Peng, D.F., Razvi, M., Chen, H., Washington, K., Roessner, A., Schneider-Stock, R. & El-Rifai, W. (2009) DNA hypermethylation regulates the expression of members of the Mu-class glutathione-S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Gut, 58, 5-15.
31. Said, A., Williams, J., Holden, J., Remington, P., Gangnon, R., Musat, A. & Lucey, M.R. (2004) Model for end stage liver disease score predicts mortality across a broad spectrum of liver disease. J. Hepatol., 40, 897-903.
32. Sarin, S.K., Kumar, A., Almeida, J.A., Chawla, Y.K., Fan, S.T., Garg, H., de Silva, H.J., Hamid, S.S., Jalan, R., Komolmit, P., Lau, G.K., Liu, Q., Madan, K., Mohamed, R., Ning, Q., Rahman, S., Rastogi, A., Riordan, S.M., Sakhuja, P., Samuel, D., Shah, S., Sharma, B.C., Sharma, P., Takikawa, Y., Thapa, B.R., Wai, C.T. & Yuen, M.F. (2009) Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol. Int., 3, 269-282.
33. Schmidt, C.C., Suttner, S.W., Piper, S.N., Nagel, D. & Boldt, J. (1999) Comparision of the effects of desfurane anaesthesia on hepatocelluler function assessed by alpha gluthatii{dotless}ne S-transferase. Anaesthesia, 54, 1207-1211.
34. Schnakenberg, E., Brener, R., Werdin, R., Dreikorn, K. & Schloot, W. (2000) Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer. Cytogenet. Cell. Genet., 91, 234-238.
35. Schulmann, K., Sterian, A., Berki, A., Yin, J., Sato, F., Xu, Y., Olaru, A., Wang, S., Mori, Y., Deacu, E., Hamilton, J., Kan, T., Krasna, M.J., Beer, D.G., Pepe, M.S., Abraham, J.M., Feng, Z., Schmiegel, W., Greenwald, B.D. & Meltzer, S.J. (2005) Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett'sassociated neoplastic progression and predicts progression risk. Oncogene, 24, 4138-4148.
36. Sen, S., Davies, N.A., Mookerjee, R.P., Cheshire, L.M., Hodges, S.J., Williams, R. & Jalan, R. (2004) Pathophysiological Effects of Albumin Dialysis in Acute-on-Chronic Liver Failure: A Randomized Controlled Study. Liver Transplantation., 10, 1109-1119.
37. Shi, Y., Lee, J.S. & Galvin, K.M. (1997) Everything you have ever wanted to know about Yin Yang 1. Biochim. Biophys. Acta., 1332, F49-F66.
38. Storz, P. (2005) Reactive oxygen species in tumor progression. Front. Biosci., 10, 1881-1896.
39. Strange, R.C., Spiteri, M.A., Ramachandran, S. & Fryer, A.A. (2001) Glutathione-S-transferase family of enzymes. Mutat. Res., 482, 21-26.
40. Suehiro, T., Matsumata, T., Shikada, Y., Shimada, M., Shirabe, K. & Sugimachi, K. (2004) Change in alpha glutathione s-transferase levels during liver resection. Hepatogastroenterology, 51, 1747-1750.
41. Wang, J., Qin, Y., Li, B., Sun, Z. & Yang, B. (2006) Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients. Clin. Biochem., 39, 344-348.
42. White, D.L., Li, D., Nurgalieva, Z. & El-Serag, H.B. (2008) Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis. Am. J. Epidemiol., 167, 377-389.
43. Wu, Q., Hou, J.G., Du, W.B., Chang, W.J., Zhai, Y.J., Lin, L.P., Tan, X.J. & Cao, G.W. (2008) Expression of glutathione-Stransferase M3 in clear cell renal cell carcinoma and its promoter CpG methylation. Academic Journal of Second Military Medical University, 29, 1273-1278.
44. Zou, Z., Li, B., Xu, D., Zhang, Z., Zhao, J.M., Zhou, G., Sun, Y., Huang, L., Fu, J., Yang, Y., Jin, L., Zhang, W., Zhao, J., Sun, Y., Xin, S. & Wang, F.S. (2008) Imbalanced intrahepatic cytokine expression of interferon-c, tumor necrosis factor-a, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection. J. Clin. Gastroenterol., 43, 182-190.