메뉴 건너뛰기




Volumn 22, Issue 15, 2016, Pages 3915-3923

PD-L1 Negative Status is Associated with Lower Mutation Burden, Differential Expression of Immune-Related Genes, and Worse Survival in Stage III Melanoma

Author keywords

[No Author keywords available]

Indexed keywords

PROGRAMMED DEATH 1 LIGAND 1; TRANSCRIPTOME; CD274 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84980047539     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-1714     Document Type: Article
Times cited : (91)

References (41)
  • 1
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002;8:793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 7
    • 84946488591 scopus 로고    scopus 로고
    • Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck
    • Thierauf J, Veit JA, Affolter A, Bergmann C, Grunow J, Laban S, et al. Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck. Melanoma Res 2015; 25:503-9.
    • (2015) Melanoma Res , vol.25 , pp. 503-509
    • Thierauf, J.1    Veit, J.A.2    Affolter, A.3    Bergmann, C.4    Grunow, J.5    Laban, S.6
  • 8
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127ra37.
    • (2012) Sci Transl Med , vol.4 , pp. 127-137
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6
  • 9
    • 84941966146 scopus 로고    scopus 로고
    • Characterization of PD-L1 expression and associated t-cell infiltrates in metastatic melanoma samples from variable anatomic sites
    • Kluger HM, Zito CR, Barr ML, Baine MK, Chiang VL, Sznol M, et al. Characterization of PD-L1 expression and associated t-cell infiltrates in metastatic melanoma samples from variable anatomic sites. Clin Cancer Res 2015;21:3052-60.
    • (2015) Clin Cancer Res , vol.21 , pp. 3052-3060
    • Kluger, H.M.1    Zito, C.R.2    Barr, M.L.3    Baine, M.K.4    Chiang, V.L.5    Sznol, M.6
  • 10
    • 84941637917 scopus 로고    scopus 로고
    • The status of PD-L1 and tumor-infiltrating immune cells predict resistance and poor prognosis in BRAFi-treated melanoma patients harboring mutant BRAFV600
    • Massi D, Brusa D, Merelli B, Falcone C, Xue G, Carobbio A, et al. The status of PD-L1 and tumor-infiltrating immune cells predict resistance and poor prognosis in BRAFi-treated melanoma patients harboring mutant BRAFV600. Ann Oncol 2015;26:1980-7.
    • (2015) Ann Oncol , vol.26 , pp. 1980-1987
    • Massi, D.1    Brusa, D.2    Merelli, B.3    Falcone, C.4    Xue, G.5    Carobbio, A.6
  • 11
    • 84927613720 scopus 로고    scopus 로고
    • PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics
    • Massi D, Brusa D, Merelli B, Ciano M, Audrito V, Serra S, et al. PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics. Ann Oncol 2014;25:2433-42.
    • (2014) Ann Oncol , vol.25 , pp. 2433-2442
    • Massi, D.1    Brusa, D.2    Merelli, B.3    Ciano, M.4    Audrito, V.5    Serra, S.6
  • 12
    • 77950283280 scopus 로고    scopus 로고
    • Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
    • Hino R, Kabashima K, Kato Y, Yagi H, Nakamura M, Honjo T, et al. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer 2010;116:1757-66.
    • (2010) Cancer , vol.116 , pp. 1757-1766
    • Hino, R.1    Kabashima, K.2    Kato, Y.3    Yagi, H.4    Nakamura, M.5    Honjo, T.6
  • 13
    • 84926678589 scopus 로고    scopus 로고
    • PD-L1 expression in melanoma shows marked heterogeneity within and between patients: Implications for anti-PD-1/PD-L1 clinical trials
    • Madore J, Vilain RE, Menzies AM, Kakavand H, Wilmott JS, Hyman J, et al. PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials. Pigment Cell Melanoma Res 2015;28:245-53.
    • (2015) Pigment Cell Melanoma Res , vol.28 , pp. 245-253
    • Madore, J.1    Vilain, R.E.2    Menzies, A.M.3    Kakavand, H.4    Wilmott, J.S.5    Hyman, J.6
  • 14
    • 84935009372 scopus 로고    scopus 로고
    • Genomic classification of cutaneous melanoma
    • The Cancer Genome Atlas Network
    • The Cancer Genome Atlas Network. Genomic classification of cutaneous melanoma. Cell 2015;161:1681-96.
    • (2015) Cell , vol.161 , pp. 1681-1696
  • 15
    • 75249087100 scopus 로고    scopus 로고
    • EdgeR: A Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 2010;26:139-40.
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 16
    • 84903146127 scopus 로고    scopus 로고
    • Robustly detecting differential expression in RNA sequencing data using observation weights
    • Zhou X, Lindsay H, Robinson MD. Robustly detecting differential expression in RNA sequencing data using observation weights. Nucleic Acids Res 2014;42:e91.
    • (2014) Nucleic Acids Res , vol.42 , pp. e91
    • Zhou, X.1    Lindsay, H.2    Robinson, M.D.3
  • 19
    • 84871342666 scopus 로고    scopus 로고
    • Cutoff Finder: A comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization
    • Budczies J, Klauschen F, Sinn BV, Gyorffy B, Schmitt WD, Darb-Esfahani S, et al. Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization. PLoS One 2012;7:e51862.
    • (2012) PLoS One , vol.7 , pp. e51862
    • Budczies, J.1    Klauschen, F.2    Sinn, B.V.3    Gyorffy, B.4    Schmitt, W.D.5    Darb-Esfahani, S.6
  • 21
    • 84865957345 scopus 로고    scopus 로고
    • Number of primary melanomas is an independent predictor of survival in patients with metastatic melanoma
    • Murali R, Brown PT, Kefford RF, Scolyer RA, Thompson JF, Atkins MB, et al. Number of primary melanomas is an independent predictor of survival in patients with metastatic melanoma. Cancer 2012;118:4519-29.
    • (2012) Cancer , vol.118 , pp. 4519-4529
    • Murali, R.1    Brown, P.T.2    Kefford, R.F.3    Scolyer, R.A.4    Thompson, J.F.5    Atkins, M.B.6
  • 24
    • 0035070697 scopus 로고    scopus 로고
    • Regulation of proteasome complexes by gamma-interferon and phosphorylation
    • Rivett AJ, Bose S, Brooks P, Broadfoot KI. Regulation of proteasome complexes by gamma-interferon and phosphorylation. Biochimie 2001; 83:363-6.
    • (2001) Biochimie , vol.83 , pp. 363-366
    • Rivett, A.J.1    Bose, S.2    Brooks, P.3    Broadfoot, K.I.4
  • 25
    • 84872595484 scopus 로고    scopus 로고
    • BRAF mutation, NRAS mutation, and the absence of an immune-related expressed gene profile predict poor outcome in patients with stage III melanoma
    • Mann GJ, Pupo GM, Campain AE, Carter CD, Schramm SJ, Pianova S, et al. BRAF mutation, NRAS mutation, and the absence of an immune-related expressed gene profile predict poor outcome in patients with stage III melanoma. J Invest Dermatol 2013;133:509-17.
    • (2013) J Invest Dermatol , vol.133 , pp. 509-517
    • Mann, G.J.1    Pupo, G.M.2    Campain, A.E.3    Carter, C.D.4    Schramm, S.J.5    Pianova, S.6
  • 26
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 2014;20: 5064-74.
    • (2014) Clin Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3    Xu, H.4    Pan, X.5    Kim, J.H.6
  • 27
    • 4344671644 scopus 로고    scopus 로고
    • Effector function of human tumor-specific CD8 T cells in melanoma lesions: A state of local functional tolerance
    • Zippelius A, Batard P, Rubio-Godoy V, Bioley G, Lienard D, Lejeune F, et al. Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res 2004;64:2865-73.
    • (2004) Cancer Res , vol.64 , pp. 2865-2873
    • Zippelius, A.1    Batard, P.2    Rubio-Godoy, V.3    Bioley, G.4    Lienard, D.5    Lejeune, F.6
  • 28
    • 84863928141 scopus 로고    scopus 로고
    • Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity
    • Loo D, Alderson RF, Chen FZ, Huang L, Zhang W, Gorlatov S, et al. Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity. Clin Cancer Res 2012;18:3834-45.
    • (2012) Clin Cancer Res , vol.18 , pp. 3834-3845
    • Loo, D.1    Alderson, R.F.2    Chen, F.Z.3    Huang, L.4    Zhang, W.5    Gorlatov, S.6
  • 29
    • 12444262173 scopus 로고    scopus 로고
    • Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy
    • Chang CC, Campoli M, Restifo NP, Wang X, Ferrone S. Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy. J Immunol 2005;174:1462-71.
    • (2005) J Immunol , vol.174 , pp. 1462-1471
    • Chang, C.C.1    Campoli, M.2    Restifo, N.P.3    Wang, X.4    Ferrone, S.5
  • 30
    • 84920774335 scopus 로고    scopus 로고
    • Exploiting natural killer cells for therapy of melanoma
    • H€olsken O, Miller M, Cerwenka A. Exploiting natural killer cells for therapy of melanoma. J Dtsch Dermatol Ges 2015;13:23-9.
    • (2015) J Dtsch Dermatol Ges , vol.13 , pp. 23-29
    • Holsken, O.1    Miller, M.2    Cerwenka, A.3
  • 31
    • 84956958113 scopus 로고    scopus 로고
    • HLA class I downregulation is associated with enhanced NK-cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors
    • Sottile R, Pangigadde PN, Tan T, Anichini A, Sabbatino F, Trecroci F, et al. HLA class I downregulation is associated with enhanced NK-cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors. Eur J Immunol 2016;46:409-19.
    • (2016) Eur J Immunol , vol.46 , pp. 409-419
    • Sottile, R.1    Pangigadde, P.N.2    Tan, T.3    Anichini, A.4    Sabbatino, F.5    Trecroci, F.6
  • 34
    • 84880276438 scopus 로고    scopus 로고
    • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
    • Robbins PF, Lu YC, El-Gamil M, Li YF, Gross C, Gartner J, et al. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat Med 2013;19:747-52.
    • (2013) Nat Med , vol.19 , pp. 747-752
    • Robbins, P.F.1    Lu, Y.C.2    El-Gamil, M.3    Li, Y.F.4    Gross, C.5    Gartner, J.6
  • 35
    • 84872841412 scopus 로고    scopus 로고
    • Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
    • van Rooij N, van Buuren MM, Philips D, Velds A, Toebes M, Heemskerk B, et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J Clin Oncol 2013;31:e439-42.
    • (2013) J Clin Oncol , vol.31 , pp. e439-e442
    • Van Rooij, N.1    Van Buuren, M.M.2    Philips, D.3    Velds, A.4    Toebes, M.5    Heemskerk, B.6
  • 36
    • 84961323160 scopus 로고    scopus 로고
    • High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4? T cells in human melanoma
    • Linnemann C, van Buuren MM, Bies L, Verdegaal EM, Schotte R, Calis JJ, et al. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4? T cells in human melanoma. Nat Med 2015; 21:81-5.
    • (2015) Nat Med , vol.21 , pp. 81-85
    • Linnemann, C.1    Van Buuren, M.M.2    Bies, L.3    Verdegaal, E.M.4    Schotte, R.5    Calis, J.J.6
  • 37
    • 84903846565 scopus 로고    scopus 로고
    • Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions
    • Lu YC, Yao X, Crystal JS, Li YF, El-Gamil M, Gross C, et al. Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions. Clin Cancer Res 2014;20:3401-10.
    • (2014) Clin Cancer Res , vol.20 , pp. 3401-3410
    • Lu, Y.C.1    Yao, X.2    Crystal, J.S.3    Li, Y.F.4    El-Gamil, M.5    Gross, C.6
  • 38
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • Rooney MS, Shukla SA, Wu CJ, Getz G, Hacohen N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 2015;160:48-61.
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 39
    • 84899836282 scopus 로고    scopus 로고
    • Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
    • Brown SD, Warren RL, Gibb EA, Martin SD, Spinelli JJ, Nelson BH, et al. Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival. Genome Res 2014;24:743-50.
    • (2014) Genome Res , vol.24 , pp. 743-750
    • Brown, S.D.1    Warren, R.L.2    Gibb, E.A.3    Martin, S.D.4    Spinelli, J.J.5    Nelson, B.H.6
  • 40
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015;348:124-8.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3    Kvistborg, P.4    Makarov, V.5    Havel, J.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.