The phosphatase calcineurin regulates pathological TDP-43 phosphorylation

Acta Neuropathologica

Volumn 132, Issue 4, 2016, Pages 545-561

  Liachko, Nicole F ^a,b   Saxton, Aleen D ^a   McMillan, Pamela J ^a,b   Strovas, Timothy J ^a   Currey, Heather N ^a   Taylor, Laura M ^b   Wheeler, Jeanna M ^a   Oblak, Adrian L ^c   Ghetti, Bernardino ^c   Montine, Thomas J ^d,e   Keene, C Dirk ^d   Raskind, Murray A ^a,b   Bird, Thomas D ^a,b,d   Kraemer, Brian C ^a,b,d  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyotrophic lateral sclerosis; Calcineurin; FK506; Frontotemporal lobar degeneration; pTDP; Tacrolimus; TARDBP; TDP 43

Indexed keywords

CALCINEURIN; TACROLIMUS; TAR DNA BINDING PROTEIN; CALCINEURIN PHOSPHATASE; DNA BINDING PROTEIN; PHOSPHATASE;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME BINDING; EXPERIMENTAL MODEL; FEMALE; FRONTAL CORTEX; FRONTOTEMPORAL DEMENTIA; HIPPOCAMPAL CA1 REGION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; MOTONEURON; MOTOR DYSFUNCTION; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RNA SPLICING; TDP 43 PROTEINOPATHY; VERY ELDERLY; ANIMAL; BRAIN; CELL INCLUSION; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; BRAIN; CAENORHABDITIS ELEGANS; CALCINEURIN; DNA-BINDING PROTEINS; INCLUSION BODIES; NEURONS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; TDP-43 PROTEINOPATHIES;

EID: 84980017377     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-016-1600-y     Document Type: Article

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