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Volumn 149, Issue , 2016, Pages 1-8

Agmatine ameliorates lipopolysaccharide induced depressive-like behaviour in mice by targeting the underlying inflammatory and oxido-nitrosative mediators

Author keywords

Agmatine; BDNF; Depressive like behaviour; Lipopolysaccharide; Oxidative stress; Pro inflammatory cytokines

Indexed keywords

AGMATINE; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTATHIONE; IMIPRAMINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; AUTACOID;

EID: 84979940411     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2016.07.004     Document Type: Article
Times cited : (48)

References (71)
  • 1
    • 40149097433 scopus 로고    scopus 로고
    • Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy
    • Adachi, M., Barrot, M., Autry, A.E., Theobald, D., Monteggia, L.M., Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol. Psychiatry 63:7 (2008), 642–649.
    • (2008) Biol. Psychiatry , vol.63 , Issue.7 , pp. 642-649
    • Adachi, M.1    Barrot, M.2    Autry, A.E.3    Theobald, D.4    Monteggia, L.M.5
  • 2
    • 84870300271 scopus 로고    scopus 로고
    • Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activity
    • Ahn, S.K., Hong, S., Park, Y.M., Choi, J.Y., Lee, W.T., Park, K.A., Lee, J.E., Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activity. Life Sci. 91 (2012), 1345–1350.
    • (2012) Life Sci. , vol.91 , pp. 1345-1350
    • Ahn, S.K.1    Hong, S.2    Park, Y.M.3    Choi, J.Y.4    Lee, W.T.5    Park, K.A.6    Lee, J.E.7
  • 3
    • 20544435255 scopus 로고    scopus 로고
    • Agmatine attenuates stress-and lipopolysaccharide induced fever in rats
    • Aricioglu, F., Regunathan, S., Agmatine attenuates stress-and lipopolysaccharide induced fever in rats. Physiol. Behav. 85 (2005), 370–375.
    • (2005) Physiol. Behav. , vol.85 , pp. 370-375
    • Aricioglu, F.1    Regunathan, S.2
  • 4
    • 1342326712 scopus 로고    scopus 로고
    • Effect of agmatine on electrically and chemically induced seizures in mice
    • Aricioglu, F., Kan, B., Yıllar, O., Korcegez, E., Berkman, K., Effect of agmatine on electrically and chemically induced seizures in mice. Ann. N. Y. Acad. Sci. 1009 (2003), 141–146.
    • (2003) Ann. N. Y. Acad. Sci. , vol.1009 , pp. 141-146
    • Aricioglu, F.1    Kan, B.2    Yıllar, O.3    Korcegez, E.4    Berkman, K.5
  • 5
    • 0028863828 scopus 로고
    • Selective inhibition of inducible nitric oxide synthase by agmatine
    • August, M., Viossat, I., Marin, J.G., Chabrier, P.E., Selective inhibition of inducible nitric oxide synthase by agmatine. Jpn. J. Pharmacol. 69 (1995), 285–287.
    • (1995) Jpn. J. Pharmacol. , vol.69 , pp. 285-287
    • August, M.1    Viossat, I.2    Marin, J.G.3    Chabrier, P.E.4
  • 7
    • 84857783771 scopus 로고    scopus 로고
    • Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats
    • Bhutada, P., Mundhada, Y., Humane, V., Rahigude, A., Deshmukh, P., Latad, S., Jain, K., Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 37:1 (2012), 96–105.
    • (2012) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.37 , Issue.1 , pp. 96-105
    • Bhutada, P.1    Mundhada, Y.2    Humane, V.3    Rahigude, A.4    Deshmukh, P.5    Latad, S.6    Jain, K.7
  • 9
    • 54049141605 scopus 로고    scopus 로고
    • Antidepressant-like effect of folic acid: involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway
    • Brocardo, P.D., Budni, J., Lobato, K.R., Kaster, M.P., Rodrigues, A.L.S., Antidepressant-like effect of folic acid: involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway. Eur. J. Pharmacol. 598 (2008), 37–42.
    • (2008) Eur. J. Pharmacol. , vol.598 , pp. 37-42
    • Brocardo, P.D.1    Budni, J.2    Lobato, K.R.3    Kaster, M.P.4    Rodrigues, A.L.S.5
  • 11
    • 55549139122 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression
    • Brunoni, A.R., Lopes, M., Fregni, F., A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int. J. Neuropsychopharmacol. 11:8 (2008), 1169–1180.
    • (2008) Int. J. Neuropsychopharmacol. , vol.11 , Issue.8 , pp. 1169-1180
    • Brunoni, A.R.1    Lopes, M.2    Fregni, F.3
  • 12
    • 77649259349 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment
    • Castrén, E., Rantamäki, T., Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment. CNS Drugs 24:1 (2010), 1–7.
    • (2010) CNS Drugs , vol.24 , Issue.1 , pp. 1-7
    • Castrén, E.1    Rantamäki, T.2
  • 13
    • 19944380200 scopus 로고    scopus 로고
    • The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice
    • Cryan, J.F., Mombereau, C., Vassout, A., The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 29 (2005), 571–625.
    • (2005) Neurosci. Biobehav. Rev. , vol.29 , pp. 571-625
    • Cryan, J.F.1    Mombereau, C.2    Vassout, A.3
  • 14
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: when the immune system subjugates the brain
    • Dantzer, R., O'Connor, J.C., Freund, G.G., Johnson, R.W., Kelley, K.W., From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9 (2008), 46–56.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 16
    • 0027366166 scopus 로고
    • A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials
    • Draper, H.H., Squires, E.J., Mahmoodi, H., Wu, J., Agarwal, S., Hadley, M., A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radic. Biol. Med. 15 (1993), 353–363.
    • (1993) Free Radic. Biol. Med. , vol.15 , pp. 353-363
    • Draper, H.H.1    Squires, E.J.2    Mahmoodi, H.3    Wu, J.4    Agarwal, S.5    Hadley, M.6
  • 17
    • 84901604292 scopus 로고    scopus 로고
    • Protective effects of agmatine against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice
    • El-Agamy, D., Makled, M., Gamil, N., Protective effects of agmatine against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice. Inflammopharmacology 22 (2014), 187–194.
    • (2014) Inflammopharmacology , vol.22 , pp. 187-194
    • El-Agamy, D.1    Makled, M.2    Gamil, N.3
  • 18
    • 3042934967 scopus 로고
    • Tissue sulfhydryl groups
    • Ellman, G.L., Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82 (1959), 70–77.
    • (1959) Arch. Biochem. Biophys. , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 19
    • 0031723196 scopus 로고    scopus 로고
    • Extracellular glutamate levels are chronically elevated in the brains of LP-BM5-infected mice: a mechanism of retrovirus-induced encephalopathy
    • Espey, M.G., Kustova, Y., Sei, Y., Basile, A.S., Extracellular glutamate levels are chronically elevated in the brains of LP-BM5-infected mice: a mechanism of retrovirus-induced encephalopathy. J. Neurochem. 71 (1998), 2079–2087.
    • (1998) J. Neurochem. , vol.71 , pp. 2079-2087
    • Espey, M.G.1    Kustova, Y.2    Sei, Y.3    Basile, A.S.4
  • 20
    • 84864759986 scopus 로고    scopus 로고
    • Neuroplastic changes in depression: a role for the immune system
    • Eyre, H., Baune, B.T., Neuroplastic changes in depression: a role for the immune system. Psychoneuroendocrinology 37 (2012), 1397–1416.
    • (2012) Psychoneuroendocrinology , vol.37 , pp. 1397-1416
    • Eyre, H.1    Baune, B.T.2
  • 23
    • 67651148093 scopus 로고    scopus 로고
    • Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment
    • Gałecki, P., Szemraj, J., Bieńkiewicz, M., Florkowski, A., Gałecka, E., Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment. Pharmacol. Rep. 61:3 (2009), 436–447.
    • (2009) Pharmacol. Rep. , vol.61 , Issue.3 , pp. 436-447
    • Gałecki, P.1    Szemraj, J.2    Bieńkiewicz, M.3    Florkowski, A.4    Gałecka, E.5
  • 25
    • 84952879798 scopus 로고    scopus 로고
    • Involvement of nitric oxide in anticompulsive-like effect of agmatine on marble-burying behaviour in mice
    • Gawali, N.B., Chowdhury, A.A., Kothavade, P.S., Bulani, V.D., Nagmoti, D.M., Juvekar, A.R., Involvement of nitric oxide in anticompulsive-like effect of agmatine on marble-burying behaviour in mice. Eur. J. Pharmacol. 770 (2016), 165–171.
    • (2016) Eur. J. Pharmacol. , vol.770 , pp. 165-171
    • Gawali, N.B.1    Chowdhury, A.A.2    Kothavade, P.S.3    Bulani, V.D.4    Nagmoti, D.M.5    Juvekar, A.R.6
  • 26
    • 79952775531 scopus 로고    scopus 로고
    • Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders
    • Gawryluk, J.W., Wang, J.F., Andreazza, A.C., Shao, L., Young, L.T., Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders. Int. J. Neuropsychopharmacol. 14 (2011), 123–130.
    • (2011) Int. J. Neuropsychopharmacol. , vol.14 , pp. 123-130
    • Gawryluk, J.W.1    Wang, J.F.2    Andreazza, A.C.3    Shao, L.4    Young, L.T.5
  • 27
    • 0030040402 scopus 로고    scopus 로고
    • Agmatine treatment is neuroprotective in rodent brain injury models
    • Gilad, G.M., Salame, K., Rabey, J.M., Gilad, V.H., Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci. 58 (1996), 41–46.
    • (1996) Life Sci. , vol.58 , pp. 41-46
    • Gilad, G.M.1    Salame, K.2    Rabey, J.M.3    Gilad, V.H.4
  • 29
    • 29144444066 scopus 로고    scopus 로고
    • Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats
    • Guan, Z., Fang, J., Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats. Brain Behav. Immun. 20 (2006), 64–71.
    • (2006) Brain Behav. Immun. , vol.20 , pp. 64-71
    • Guan, Z.1    Fang, J.2
  • 30
    • 80051471037 scopus 로고    scopus 로고
    • Effects of exogenous agmatine in human leukemia HMC-1 and HL-60 cells on proliferation, polyamine metabolism and cell cycle
    • Haenisch, B., Bönisch, H., Cichon, S., Allam, J.P., Novak, N., Molderings, G.J., Effects of exogenous agmatine in human leukemia HMC-1 and HL-60 cells on proliferation, polyamine metabolism and cell cycle. Leuk. Res. 35:9 (2011), 1248–1253.
    • (2011) Leuk. Res. , vol.35 , Issue.9 , pp. 1248-1253
    • Haenisch, B.1    Bönisch, H.2    Cichon, S.3    Allam, J.P.4    Novak, N.5    Molderings, G.J.6
  • 31
    • 35048891421 scopus 로고    scopus 로고
    • Agmatine metabolic pathway and spectrum of activity in brain
    • Halaris, A., Plietz, J., Agmatine metabolic pathway and spectrum of activity in brain. CNS Drugs 21:11 (2007), 885–900.
    • (2007) CNS Drugs , vol.21 , Issue.11 , pp. 885-900
    • Halaris, A.1    Plietz, J.2
  • 32
    • 0032806929 scopus 로고    scopus 로고
    • Plasma agmatine and platelet imidazoline receptors in depression
    • Halaris, A., Zhu, H., Feng, Y., Piletz, J.E., Plasma agmatine and platelet imidazoline receptors in depression. Ann. N. Y. Acad. Sci. 881 (1999), 445–451.
    • (1999) Ann. N. Y. Acad. Sci. , vol.881 , pp. 445-451
    • Halaris, A.1    Zhu, H.2    Feng, Y.3    Piletz, J.E.4
  • 34
    • 0035003814 scopus 로고    scopus 로고
    • Protective effect of vitamin E, beta-carotene and N-acetylcysteine from the brain oxidative stress induced in rats by lipopolysaccharide
    • Kheir-Eldin, A.A., Motawi, T.K., Gad, M.Z., Abd-ElGawad, H.M., Protective effect of vitamin E, beta-carotene and N-acetylcysteine from the brain oxidative stress induced in rats by lipopolysaccharide. Int. J. Biochem. Cell Biol. 33 (2001), 475–482.
    • (2001) Int. J. Biochem. Cell Biol. , vol.33 , pp. 475-482
    • Kheir-Eldin, A.A.1    Motawi, T.K.2    Gad, M.Z.3    Abd-ElGawad, H.M.4
  • 37
    • 79957815233 scopus 로고    scopus 로고
    • Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: a 24-week follow-up study
    • Kotan, V.O., Sarandol, E., Kirhan, E., Ozkaya, G., Kirli, S., Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: a 24-week follow-up study. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 35:5 (2011), 1284–1290.
    • (2011) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.35 , Issue.5 , pp. 1284-1290
    • Kotan, V.O.1    Sarandol, E.2    Kirhan, E.3    Ozkaya, G.4    Kirli, S.5
  • 38
    • 79958088436 scopus 로고    scopus 로고
    • Animal models of depression: molecular perspectives
    • Krishnan, V., Nestler, E.J., Animal models of depression: molecular perspectives. Curr. Top. Behav. Neurosci. 7 (2011), 121–147.
    • (2011) Curr. Top. Behav. Neurosci. , vol.7 , pp. 121-147
    • Krishnan, V.1    Nestler, E.J.2
  • 39
    • 79551648304 scopus 로고    scopus 로고
    • The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment
    • Lee, B.H., Kim, Y.K., The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Investig 7 (2010), 231–235.
    • (2010) Psychiatry Investig , vol.7 , pp. 231-235
    • Lee, B.H.1    Kim, Y.K.2
  • 40
    • 84856080795 scopus 로고    scopus 로고
    • Review of pharmacological treatment in mood disorders and future directions for drug development
    • Li, X., Frye, M.A., Shelton, R.C., Review of pharmacological treatment in mood disorders and future directions for drug development. Neuropsychopharmacology 37 (2012), 77–101.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 77-101
    • Li, X.1    Frye, M.A.2    Shelton, R.C.3
  • 41
    • 84948649423 scopus 로고    scopus 로고
    • A meta-analysis of oxidative stress markers in depression
    • e0138904
    • Liu, T., Zhong, S., Liao, X., Chen, J., He, T., Lai, S., Jia, Y., A meta-analysis of oxidative stress markers in depression. PLoS One, 10, 2015, e0138904.
    • (2015) PLoS One , vol.10
    • Liu, T.1    Zhong, S.2    Liao, X.3    Chen, J.4    He, T.5    Lai, S.6    Jia, Y.7
  • 42
    • 84886259029 scopus 로고    scopus 로고
    • A review of peripheral biomarkers in major depression: the potential of inflammatory and oxidative stress biomarkers
    • Lopresti, A.L., Maker, G.L., Hood, S.D., Drummond, P.D., A review of peripheral biomarkers in major depression: the potential of inflammatory and oxidative stress biomarkers. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 48 (2014), 102–111.
    • (2014) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.48 , pp. 102-111
    • Lopresti, A.L.1    Maker, G.L.2    Hood, S.D.3    Drummond, P.D.4
  • 43
    • 0028796205 scopus 로고
    • Evidence for an immune response in major depression: a review and hypothesis
    • Maes, M., Evidence for an immune response in major depression: a review and hypothesis. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 19 (1995), 11–38.
    • (1995) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.19 , pp. 11-38
    • Maes, M.1
  • 44
    • 79954598830 scopus 로고    scopus 로고
    • Depression is an inflammatory disease, but cell mediated immune activation is the key component of depression
    • Maes, M., Depression is an inflammatory disease, but cell mediated immune activation is the key component of depression. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 35:3 (2011), 664–675.
    • (2011) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.35 , Issue.3 , pp. 664-675
    • Maes, M.1
  • 45
    • 79954568978 scopus 로고    scopus 로고
    • A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness
    • Maes, M., Galecki, P., Chang, Y.S., Berk, M., A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 35 (2011), 676–692.
    • (2011) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.35 , pp. 676-692
    • Maes, M.1    Galecki, P.2    Chang, Y.S.3    Berk, M.4
  • 47
    • 33646708039 scopus 로고    scopus 로고
    • Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study
    • Mendlewicz, J., Kriwin, P., Oswald, P., Souery, D., Alboni, S., Brunello, N., Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study. Int. Clin. Psychopharmacol. 21 (2006), 227–231.
    • (2006) Int. Clin. Psychopharmacol. , vol.21 , pp. 227-231
    • Mendlewicz, J.1    Kriwin, P.2    Oswald, P.3    Souery, D.4    Alboni, S.5    Brunello, N.6
  • 48
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    • Miller, A.H., Maletic, V., Raison, C.L., Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65 (2009), 732–741.
    • (2009) Biol. Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 50
    • 0029907597 scopus 로고    scopus 로고
    • Evidence-based health policy—lessons from the global burden of disease study
    • Murray, C.J., Lopez, A.D., Evidence-based health policy—lessons from the global burden of disease study. Science 274 (1996), 740–743.
    • (1996) Science , vol.274 , pp. 740-743
    • Murray, C.J.1    Lopez, A.D.2
  • 51
    • 84885788151 scopus 로고    scopus 로고
    • Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis
    • Na, K.S., Lee, K.J., Lee, J.S., Cho, Y.S., Jung, H.Y., Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 20 (2013), 79–85.
    • (2013) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.20 , pp. 79-85
    • Na, K.S.1    Lee, K.J.2    Lee, J.S.3    Cho, Y.S.4    Jung, H.Y.5
  • 52
    • 65349135346 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2, 3-dioxygenase activation in mice
    • O'Connor, J.C., Lawson, M.A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K.W., Dantzer, R., Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2, 3-dioxygenase activation in mice. Mol. Psychiatry 14 (2009), 511–522.
    • (2009) Mol. Psychiatry , vol.14 , pp. 511-522
    • O'Connor, J.C.1    Lawson, M.A.2    André, C.3    Moreau, M.4    Lestage, J.5    Castanon, N.6    Kelley, K.W.7    Dantzer, R.8
  • 53
    • 84872534794 scopus 로고    scopus 로고
    • Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration
    • Ohgi, Y., Futamura, T., Kikuchi, T., Hashimoto, K., Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration. Pharmacol. Biochem. Behav. 103 (2013), 853–859.
    • (2013) Pharmacol. Biochem. Behav. , vol.103 , pp. 853-859
    • Ohgi, Y.1    Futamura, T.2    Kikuchi, T.3    Hashimoto, K.4
  • 54
    • 0017618768 scopus 로고
    • Depression: a new animal model sensitive to antidepressant treatments
    • Porsolt, R.D., Le Pichon, M., Jalfre, M., Depression: a new animal model sensitive to antidepressant treatments. Nat Rev Neurosci 266 (1977), 730–732.
    • (1977) Nat Rev Neurosci , vol.266 , pp. 730-732
    • Porsolt, R.D.1    Le Pichon, M.2    Jalfre, M.3
  • 55
    • 84866146120 scopus 로고    scopus 로고
    • Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia
    • Puntener, U., Booth, S.G., Perry, V.H., Teeling, J.L., Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia. J. Neuroinflammation, 9, 2012, 146.
    • (2012) J. Neuroinflammation , vol.9 , pp. 146
    • Puntener, U.1    Booth, S.G.2    Perry, V.H.3    Teeling, J.L.4
  • 56
    • 0034193104 scopus 로고    scopus 로고
    • Is agmatine a novel neurotransmitter in brain?
    • Reis, D., Regunathan, S., Is agmatine a novel neurotransmitter in brain?. Trends Pharmacol. Sci. 21 (2000), 187–193.
    • (2000) Trends Pharmacol. Sci. , vol.21 , pp. 187-193
    • Reis, D.1    Regunathan, S.2
  • 58
    • 0032521641 scopus 로고    scopus 로고
    • Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines
    • Sastre, M., Galea, E., Feinstein, D., Reis, D., Regunathan, S., Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines. Biochem. J. 330 (1998), 1405–1409.
    • (1998) Biochem. J. , vol.330 , pp. 1405-1409
    • Sastre, M.1    Galea, E.2    Feinstein, D.3    Reis, D.4    Regunathan, S.5
  • 59
    • 25144435958 scopus 로고    scopus 로고
    • Systemic inflammation induces apoptosis with variable vulnerability of different brain regions
    • Semmler, A., Okulla, T., Sastre, M., Dumitrescu-Ozimek, L., Heneka, M.T., Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J. Chem. Neuroanat. 30 (2005), 144–157.
    • (2005) J. Chem. Neuroanat. , vol.30 , pp. 144-157
    • Semmler, A.1    Okulla, T.2    Sastre, M.3    Dumitrescu-Ozimek, L.4    Heneka, M.T.5
  • 61
    • 0021990491 scopus 로고
    • The tail suspension test: a new method for screening antidepressants in mice
    • Steru, L., Chermat, R., Thierry, B., Simon, P., The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:3 (1985), 367–670.
    • (1985) Psychopharmacology , vol.85 , Issue.3 , pp. 367-670
    • Steru, L.1    Chermat, R.2    Thierry, B.3    Simon, P.4
  • 62
    • 84918807004 scopus 로고    scopus 로고
    • Honokiol abrogates lipopolysaccharide-induced depressive-like behaviour by impeding neuroinflammation andoxido-nitrosative stress in mice
    • Sulakhiya, K., Kumar, P., Jangra, A., Dwivedi, S., Hazarika, N.K., Baruah, C.C., Lahkar, M., Honokiol abrogates lipopolysaccharide-induced depressive-like behaviour by impeding neuroinflammation andoxido-nitrosative stress in mice. Eur. J. Pharmacol. 744 (2014), 124–131.
    • (2014) Eur. J. Pharmacol. , vol.744 , pp. 124-131
    • Sulakhiya, K.1    Kumar, P.2    Jangra, A.3    Dwivedi, S.4    Hazarika, N.K.5    Baruah, C.C.6    Lahkar, M.7
  • 63
    • 0028916077 scopus 로고
    • Lipopolysaccharide induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors
    • Tracey, W.R., Tse, J., Carter, G., Lipopolysaccharide induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors. J. Pharmacol. Exp. Ther. 282:3 (1995), 1011–1015.
    • (1995) J. Pharmacol. Exp. Ther. , vol.282 , Issue.3 , pp. 1011-1015
    • Tracey, W.R.1    Tse, J.2    Carter, G.3
  • 65
    • 82855165088 scopus 로고    scopus 로고
    • The pharmacological importance of agmatine in the brain
    • Uzbay, T.I., The pharmacological importance of agmatine in the brain. Neurosci. Biobehav. Rev. 36 (2012), 502–519.
    • (2012) Neurosci. Biobehav. Rev. , vol.36 , pp. 502-519
    • Uzbay, T.I.1
  • 66
    • 84883335706 scopus 로고    scopus 로고
    • Low serum brain derived neurotrophic factor in non-suicidal out-patients with depression: relation to depression scores
    • Varambally, S., Naveen, G.H., Rao, M.G., Thirthalli, J., Sharma, R., Christopher, R., Gangadhar, B.N., Low serum brain derived neurotrophic factor in non-suicidal out-patients with depression: relation to depression scores. Indian J. Psychiatry 55:3 (2013), S397–S399.
    • (2013) Indian J. Psychiatry , vol.55 , Issue.3 , pp. S397-S399
    • Varambally, S.1    Naveen, G.H.2    Rao, M.G.3    Thirthalli, J.4    Sharma, R.5    Christopher, R.6    Gangadhar, B.N.7
  • 67
    • 33646395679 scopus 로고    scopus 로고
    • Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons
    • Wang, W.P., Iyo, A.H., Miguel-Hidalgo, J., Regunathan, S., Zhu, M.Y., Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res. 1084 (2006), 210–216.
    • (2006) Brain Res. , vol.1084 , pp. 210-216
    • Wang, W.P.1    Iyo, A.H.2    Miguel-Hidalgo, J.3    Regunathan, S.4    Zhu, M.Y.5
  • 68
    • 84927639238 scopus 로고    scopus 로고
    • Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation
    • Zhang, J.C., Wu, J., Fujita, Y., Yao, W., Ren, Q., Yang, C., Li, S.X., Shirayama, Y., Hashimoto, K., Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol, 18(4), 2015, pyu077.
    • (2015) Int J Neuropsychopharmacol , vol.18 , Issue.4 , pp. pyu077
    • Zhang, J.C.1    Wu, J.2    Fujita, Y.3    Yao, W.4    Ren, Q.5    Yang, C.6    Li, S.X.7    Shirayama, Y.8    Hashimoto, K.9
  • 69
    • 0041315718 scopus 로고    scopus 로고
    • Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells
    • Zhu, M.Y., Piletz, J.E., Halaris, A., Regunathan, S., Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells. Cell. Mol. Neurobiol. 23 (2003), 865–872.
    • (2003) Cell. Mol. Neurobiol. , vol.23 , pp. 865-872
    • Zhu, M.Y.1    Piletz, J.E.2    Halaris, A.3    Regunathan, S.4
  • 71
    • 4544249477 scopus 로고    scopus 로고
    • Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test
    • Zomkowski, A.D.E., Rosa, A.O., Lin, J., Santos, A.R.S., Calixto, J.B., Rodrigues, A.L.S., Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test. Brain Res. 1023 (2004), 253–263.
    • (2004) Brain Res. , vol.1023 , pp. 253-263
    • Zomkowski, A.D.E.1    Rosa, A.O.2    Lin, J.3    Santos, A.R.S.4    Calixto, J.B.5    Rodrigues, A.L.S.6


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