Development of a fully integrated falling film microreactor for gas–liquid–solid biotransformation with surface immobilized O2-dependent enzyme

Biotechnology and Bioengineering

Volumn 113, Issue 9, 2016, Pages 1862-1872

  Bolivar, Juan M ^a   Krämer, Christina E M ^a   Ungerböck, Birgit ^a   Mayr, Torsten ^a   Nidetzky, Bernd ^a,b  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

Author keywords

falling film microreactor; gas liquid solid biotransformation; immobilized oxidase; microchannel; oxygen mass transfer; Zbasic2 binding module

Indexed keywords

BIOACTIVITY; CHEMICAL REACTORS; ENZYME IMMOBILIZATION; ENZYMES; GASES; LIQUIDS; MICROCHANNELS; MICROSTRUCTURE; PROTEINS;

CONCENTRATION MEASUREMENT; IMMOBILIZATION OF CATALYSTS; IMMOBILIZED OXIDASE; LIQUID-SIDE MASS TRANSFER COEFFICIENTS; MICRO-REACTOR; OVERALL MASS TRANSFER COEFFICIENT; OXYGEN MASS TRANSFER; ZBASIC2-BINDING MODULE;

MASS TRANSFER;

CHIMERIC PROTEIN; DEXTRO AMINO ACID OXIDASE; IMMOBILIZED ENZYME; OXYGEN; STAINLESS STEEL;

ARTICLE; BIOCATALYST; BIOTRANSFORMATION; CAMERA; CONCENTRATION (PARAMETERS); ELECTRIC POTENTIAL; ENZYME IMMOBILIZATION; FALLING FILM MICROREACTOR; FLOW RATE; GAS; HYDRODYNAMICS; IMMOBILIZED ENZYME REACTOR; LIQUID; MASS TRANSFER COEFFICIENT; MICROCHANNEL; OXIDATION; OXYGEN TRANSPORT; PHYSICAL PARAMETERS; PROTEIN PROTEIN INTERACTION; PUMP; SOLID; SURFACE AREA; SURFACE PROPERTY; THICKNESS;

EID: 84979784669     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25969     Document Type: Article

References (58)

1. Bolivar JM, Nidetzky B. 2012a. Oriented and selective enzyme immobilization on functionalized silica carrier using the cationic binding module Z basic2: Design of a heterogeneous D-amino acid oxidase catalyst on porous glass. Biotechnol Bioeng 109:1490–1498.
2. Bolivar JM, Nidetzky B. 2012b. Positively charged mini-protein Zbasic2 as a highly efficient silica binding module: Opportunities for enzyme immobilization on unmodified silica supports. Langmuir 28:10040–10049.
3. Bolivar JM, Nidetzky B. 2013. Multiphase biotransformations in microstructured reactors: Opportunities for biocatalytic process intensification and smart flow processing. Green Process Synth 2:541–559.
4. Bolivar JM, Schelch S, Mayr T, Nidetzky B. 2015. Mesoporous silica materials labeled for optical oxygen sensing and their application to development of a silica-supported oxidoreductase biocatalyst. ACS Catal 5:5984–5993.
5. Bolivar JM, Wiesbauer J, Nidetzky B. 2011. Biotransformations in microstructured reactors: More than flowing with the stream? Trends Biotechnol 29:333–342.
6. Commenge J-M, Obein T, Framboisier X, Rode S, Pitiot P, Matlosz M. 2011. Gas-phase mass-transfer measurements in a falling-film microreactor. Chem Eng Sci 66:1212–1218.
7. Commenge J-M, Obein T, Genin G, Framboisier X, Rode S, Schanen V, Pitiot P, Matlosz M. 2006. Gas-phase residence time distribution in a falling-film microreactor. Chem Eng Sci 61:597–604.
8. Dencic I, Hessel V, de Croon MHJM, Meuldijk J, van der Doelen CWJ, Koch K. 2012. Recent changes in patenting behavior in microprocess technology and its possible use for gas-liquid reactions and the oxidation of glucose. ChemSusChem 5:232–245.
9. Dencic I, Meuldijk J, de Croon M, Hessel V. 2011. From a review of noble metal versus enzyme catalysts for glucose oxidation under conventional conditions towards a process design analysis for continuous-flow operation. J Flow Chem 1:13–23.
10. Dib I, Nidetzky B. 2008. The stabilizing effects of immobilization in D-amino acid oxidase from Trigonopsis variabilis. BMC Biotechnol 8:72.
11. Fercher A, Borisov SM, Zhdanov AV, Klimant I, Papkovsky DB. 2011. Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles. ACS Nano 5:5499–5508.
12. Fernandes P. 2010. Miniaturization in biocatalysis. Int J Mol Sci 11:858–879.
13. Garcia-Ochoa F, Gomez E. 2009. Bioreactor scale-up and oxygen transfer rate in microbial processes: An overview. Biotechnol Adv 27:153–176.
14. Gemoets HPL, Su Y, Shang M, Hessel V, Luque R, Noël T. 2016. Liquid phase oxidation chemistry in continuous-flow microreactors. Chem Soc Rev 45:83–117.
15. Günther A, Jensen KF. 2006. Multiphase microfluidics: From flow characteristics to chemical and materials synthesis. Lab Chip 6:1487–1503.
16. Gutmann B, Cantillo D, Kappe CO. 2015. Continuous-flow technology-a tool for the safe manufacturing of active pharmaceutical ingredients. Angew Chem Int Ed 54:6688–6728.
17. Hall M, Bommarius AS. 2011. Enantioenriched compounds via enzyme-catalyzed redox reactions. Chem Rev 111:4088–4110.
18. Hartman RL, Jensen KF. 2009. Microchemical systems for continuous-flow synthesis. Lab Chip 9:2495–2507.
19. Hessel V, Angeli P, Gavriilidis A, Löwe H. 2005. Gas-liquid and gas-liquid-solid microstructured reactors: Contacting principles and applications. Ind Eng Chem Res 44:9750–9769.
20. Hessel V, Tibhe J, Noël T, Wang Q. 2014. Biotechnical micro-flow processing at the EDGE—Lessons to be learnt for a young Discipline. Chem Biochem Eng Q J 28:167–188.
21. Hollmann F, Arends IWCE, Buehler K, Schallmey A, Bühler B. 2011. Enzyme-mediated oxidations for the chemist. Green Chem 13:226.
22. Illner S, Hofmann C, Löb P, Kragl U. 2014. A falling-film microreactor for enzymatic oxidation of glucose. ChemCatChem 6:1748–1754.
23. Jähnisch K, Hessel V, Löwe H, Baerns M. 2004. Chemistry in microstructured reactors. Angew Chem Int Ed 43:406–446.
24. Karande R, Schmid A, Buehler K. 2016. Applications of multiphasic microreactors for biocatalytic reactions. Org Process Res Dev 20:361–370.
25. Kashid MN, Kiwi-Minsker L. 2009. Microstructured reactors for multiphase reactions: State of the art. Ind Eng Chem Res 48:6465–6485.
26. Kashid MN, Renken A, Kiwi-Minsker L. 2011. Gas-liquid and liquid-liquid mass transfer in microstructured reactors. Chem Eng Sci 66:3876–3897.
27. Kawakami K, Adachi K, Minemura N, Kusunoki K. 1989b. Characteristics of a gas-liquid-solid, three-phase, honey-comb-monolith bioreactor. Oxidation of glucose by immobilized glucose oxidase. Int Chem Eng 29:320–327.
28. Kawakami K, Kawasaki K, Shiraishi F, Kusunoki K. 1989a. Performance of a honeycomb monolith bioreactor in a gas-liquid-solid three-phase system. Ind Eng Chem Res 28:394–400.
29. Lundemo MT, Woodley JM. 2015. Guidelines for development and implementation of biocatalytic P450 processes. Appl Microbiol Biotechnol 99:2465–2483.
30. Mallat T, Baiker A. 2004. Oxidation of alcohols with molecular oxygen on solid catalysts. Chem Rev 104:3037–3058.
31. Mhiri N, Monnier H, Falk L. 2011. Intensification of the G/L absorption in microstructured falling film application to the treatment of chlorinated VOC's. Part III: Influence of gas thickness channel on mass transfer. Chem Eng Sci 66:5989–6001.
32. Monnier H, Falk L. 2011. Intensification of G/L absorption in microstructured falling film. Application to the treatment of chlorinated VOC's—Part II: Modeling and geometric optimization. Chem Eng Sci 66:2475–2490.
33. Monnier H, Falk L, Lapicque F, Hadjoudj R, Roizard C. 2010. Intensification of G/L absorption in microstructured falling film. Application to the treatment of chlorinated VOC's—Part I: Comparison between structured and microstructured packings in absorption devices. Chem Eng Sci 65:6425–6434.
34. Monti D, Ottolina G, Carrea G, Riva S. 2011. Redox reactions catalyzed by isolated enzymes. Chem Rev 111:4111–4140.
35. Moser C, Mayr T, Klimant I. 2006. Microsphere sedimentation arrays for multiplexed bioanalytics. Anal Chim Acta 558:102–109.
36. Pennemann H, Watts P, Haswell SJ, Hessel V, Löwe H. 2004. Benchmarking of microreactor applications. Org Process Res Dev 8:422–439.
37. Podgoršek A, Zupan M, Iskra J. 2009. Oxidative halogenation with “green” oxidants: Oxygen and hydrogen peroxide. Angew Chem Int Ed 48:8424–8450.
38. Punniyamurthy T, Velusamy S, Iqbal J. 2005. Recent advances in transition metal catalyzed oxidation of organic substrates with molecular oxygen. Chem Rev 105:2329–2363.
39. Que L, Tolman WB. 2008. Biologically inspired oxidation catalysis. Nature 455:333–340.
40. Rebrov EV, Duisters T, Löb P, Meuldijk J, Hessel V. 2012. Enhancement of the liquid-side mass transfer in a falling film catalytic microreactor by in-channel mixing structures. Ind Eng Chem Res 51:8719–8725.
41. Schagen A, Modigell M. 2004. Luminescence technique for the measurement of local concentration distribution in thin liquid films. Exp Fluids 38:174–184.
42. Schagen A, Modigell M. 2007. Local film thickness and temperature distribution measurement in wavy liquid films with a laser-induced luminescence technique. Exp Fluids 43:209–221.
43. Sheldon RA. 2015. Recent advances in green catalytic oxidations of alcohols in aqueous media. Catal Today 247:4–13.
44. Sheldon RA, Arends IWCE, Brink GJT, Dijksman A. 2002. Green, catalytic oxidations of alcohols. Acc Chem Res 35:774–781.
45. Shi Z, Zhang C, Tang C, Jiao N. 2012. Recent advances in transition-metal catalyzed reactions using molecular oxygen as the oxidant. Chem Soc Rev 41:3381–3430.
46. Sobieszuk P, Aubin J, Pohorecki R. 2012. Hydrodynamics and mass transfer in gas-liquid flows in microreactors. Chem Eng Technol 35:1346–1358.
47. Tomaszewski B, Lloyd RC, Warr AJ, Buehler K, Schmid A. 2014a. Regioselective biocatalytic aromatic hydroxylation in a gas-liquid multiphase tube-in-tube reactor. ChemCatChem 6:2567–2576.
48. Tomaszewski B, Schmid A, Buehler K. 2014b. Biocatalytic production of catechols using a high pressure tube-in-tube segmented flow microreactor. Org Process Res Dev 18:1516–1526.
49. Tufvesson P, Lima-Ramos J, Haque NA, Gernaey KV, Woodley JM. 2013. Advances in the process development of biocatalytic processes Org Process Res. Dev 17:1233–1238.
50. Turner NJ. 2011. Enantioselective oxidation of C-O and C-N bonds using oxidases. Chem Rev 111:4073–4087.
51. Wiesbauer J, Bolivar JM, Mueller M, Schiller M, Nidetzky B. 2011. Oriented Immobilization of enzymes made fit for applied biocatalysis: Non-covalent attachment to anionic supports using Zbasic2 module. ChemCatChem 3:1299–1303.
52. Wohlgemuth R, Plazl I, Žnidaršič-Plazl P, Gernaey KV, Woodley JM. 2015. Microscale technology and biocatalytic processes: Opportunities and challenges for synthesis. Trends Biotechnol 33:302–314.
53. Woodley JM. 2006. Microbial biocatalytic processes and their development. Adv Appl Microbiol 60:1–15.
54. Yeong KK, Gavriilidis A, Zapf R, Hessel V. 2004. Experimental studies of nitrobenzene hydrogenation in a microstructured falling film reactor. Chem Eng Sci 59:3491–3494.
55. Yeong KK, Gavriilidis A, Zapf R, Kost H-J, Hessel V, Boyde A. 2006. Characterisation of liquid film in a microstructured falling film reactor using laser scanning confocal microscopy. Exp Therm Fluid Sci 30:463–472.
56. Yue J, Chen G, Yuan Q, Luo L, Gonthier Y. 2007. Hydrodynamics and mass transfer characteristics in gas-liquid flow through a rectangular microchannel. Chem Eng Sci 62:2096–2108.
57. Zanfir M, Gavriilidis A, Wille C, Hessel V. 2005. Carbon dioxide absorption in a falling film microstructured reactor: Experiments and modeling. Ind Eng Chem Res 44:1742–1751.
58. Zhang H, Chen G, Yue J, Yuan Q. 2009. Hydrodynamics and mass transfer of gas-liquid flow in a falling film microreactor. AIChE J 55:1110–1120.