메뉴 건너뛰기




Volumn 64, Issue 4, 2016, Pages 1072-1085

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; HETERODIMER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; OBETICHOLIC ACID; OXYGENASE; STEROL 12ALPHA HYDROXYLASE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR;

EID: 84979774653     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.28712     Document Type: Article
Times cited : (129)

References (44)
  • 1
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009;89:147–191.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 2
    • 84952978609 scopus 로고    scopus 로고
    • Farnesoid X receptor—acting through bile acids to treat metabolic disorders
    • Zhang Y. Farnesoid X receptor—acting through bile acids to treat metabolic disorders. Drugs Future 2010;35:635–641.
    • (2010) Drugs Future , vol.35 , pp. 635-641
    • Zhang, Y.1
  • 3
    • 84925507991 scopus 로고    scopus 로고
    • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
    • Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 2015;21:159–165.
    • (2015) Nat Med , vol.21 , pp. 159-165
    • Fang, S.1    Suh, J.M.2    Reilly, S.M.3    Yu, E.4    Osborn, O.5    Lackey, D.6
  • 4
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A 2006;103:1006–1011.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5    Gonzalez, F.J.6
  • 5
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013;145:574–582.e1.
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3    Morrow, L.4    Marschall, H.U.5    Kipnes, M.6
  • 6
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006;116:1102–1109.
    • (2006) J Clin Invest , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 7
    • 84887477319 scopus 로고    scopus 로고
    • Bile acid receptors in non-alcoholic fatty liver disease
    • Li Y, Jadhav K, Zhang Y. Bile acid receptors in non-alcoholic fatty liver disease. Biochem Pharmacol 2013;86:1517–1524.
    • (2013) Biochem Pharmacol , vol.86 , pp. 1517-1524
    • Li, Y.1    Jadhav, K.2    Zhang, Y.3
  • 8
    • 77449123194 scopus 로고    scopus 로고
    • Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia
    • Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA. Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. J Biol Chem 2010;285:3035–3043.
    • (2010) J Biol Chem , vol.285 , pp. 3035-3043
    • Zhang, Y.1    Yin, L.2    Anderson, J.3    Ma, H.4    Gonzalez, F.J.5    Willson, T.M.6    Edwards, P.A.7
  • 9
    • 33745132444 scopus 로고    scopus 로고
    • Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?
    • Cuchel M, Rader DJ. Macrophage reverse cholesterol transport: key to the regression of atherosclerosis? Circulation 2006;113:2548–2555.
    • (2006) Circulation , vol.113 , pp. 2548-2555
    • Cuchel, M.1    Rader, D.J.2
  • 10
    • 84859760161 scopus 로고    scopus 로고
    • Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport
    • Rosenson RS, Brewer HB, Jr., Davidson WS, Fayad ZA, Fuster V, Goldstein J, et al. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation 2012;125:1905–1919.
    • (2012) Circulation , vol.125 , pp. 1905-1919
    • Rosenson, R.S.1    Brewer, H.B.2    Davidson, W.S.3    Fayad, Z.A.4    Fuster, V.5    Goldstein, J.6
  • 12
    • 64349115048 scopus 로고    scopus 로고
    • Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)
    • Flatt B, Martin R, Wang TL, Mahaney P, Murphy B, Gu XH, et al. Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR). J Med Chem 2009;52:904–907.
    • (2009) J Med Chem , vol.52 , pp. 904-907
    • Flatt, B.1    Martin, R.2    Wang, T.L.3    Mahaney, P.4    Murphy, B.5    Gu, X.H.6
  • 13
    • 84887477319 scopus 로고    scopus 로고
    • Bile acid receptors in non-alcoholic fatty liver disease
    • Li Y, Jadhav K, Zhang Y. Bile acid receptors in non-alcoholic fatty liver disease. Biochem Pharmacol 2013;86:1517–1524.
    • (2013) Biochem Pharmacol , vol.86 , pp. 1517-1524
    • Li, Y.1    Jadhav, K.2    Zhang, Y.3
  • 14
    • 37349010675 scopus 로고    scopus 로고
    • FXR signaling in metabolic disease
    • Zhang Y, Edwards PA. FXR signaling in metabolic disease. FEBS Lett 2008;582:10–18.
    • (2008) FEBS Lett , vol.582 , pp. 10-18
    • Zhang, Y.1    Edwards, P.A.2
  • 15
    • 84864861866 scopus 로고    scopus 로고
    • Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
    • Porez G, Prawitt J, Gross B, Staels B. Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. J Lipid Res 2012;53:1723–1737.
    • (2012) J Lipid Res , vol.53 , pp. 1723-1737
    • Porez, G.1    Prawitt, J.2    Gross, B.3    Staels, B.4
  • 16
    • 0037414757 scopus 로고    scopus 로고
    • Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    • Zhang Y, Kast-Woelbern HR, Edwards PA. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J Biol Chem 2003;278:104–110.
    • (2003) J Biol Chem , vol.278 , pp. 104-110
    • Zhang, Y.1    Kast-Woelbern, H.R.2    Edwards, P.A.3
  • 17
    • 11144357090 scopus 로고    scopus 로고
    • Scavenger receptor type BI potentiates reverse cholesterol transport system by removing cholesterol ester from HDL
    • Kinoshita M, Fujita M, Usui S, Maeda Y, Kudo M, Hirota D, et al. Scavenger receptor type BI potentiates reverse cholesterol transport system by removing cholesterol ester from HDL. Atherosclerosis 2004;173:197–202.
    • (2004) Atherosclerosis , vol.173 , pp. 197-202
    • Kinoshita, M.1    Fujita, M.2    Usui, S.3    Maeda, Y.4    Kudo, M.5    Hirota, D.6
  • 18
    • 26444546843 scopus 로고    scopus 로고
    • Shifting gears: liver SR-BI drives reverse cholesterol transport in macrophages
    • van der Velde AE, Groen AK. Shifting gears: liver SR-BI drives reverse cholesterol transport in macrophages. J Clin Invest 2005;115:2699–2701.
    • (2005) J Clin Invest , vol.115 , pp. 2699-2701
    • van der Velde, A.E.1    Groen, A.K.2
  • 20
    • 84917691001 scopus 로고    scopus 로고
    • Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice
    • Huang Y, Wang J, Quan G, Wang X, Yang L, Zhong L. Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice. Appl Environ Microbiol 2014;80:7496–7504.
    • (2014) Appl Environ Microbiol , vol.80 , pp. 7496-7504
    • Huang, Y.1    Wang, J.2    Quan, G.3    Wang, X.4    Yang, L.5    Zhong, L.6
  • 21
    • 84884509078 scopus 로고    scopus 로고
    • Inhibition of intestinal cholesterol absorption with ezetimibe increases components of reverse cholesterol transport in humans
    • Davidson MH, Voogt J, Luchoomun J, Decaris J, Killion S, Boban D, et al. Inhibition of intestinal cholesterol absorption with ezetimibe increases components of reverse cholesterol transport in humans. Atherosclerosis 2013;230:322–329.
    • (2013) Atherosclerosis , vol.230 , pp. 322-329
    • Davidson, M.H.1    Voogt, J.2    Luchoomun, J.3    Decaris, J.4    Killion, S.5    Boban, D.6
  • 22
    • 0041965752 scopus 로고    scopus 로고
    • Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse
    • Wang DQ, Tazuma S, Cohen DE, Carey MC. Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse. Am J Physiol Gastrointest Liver Physiol 2003;285:G494–G502.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285 , pp. G494-G502
    • Wang, D.Q.1    Tazuma, S.2    Cohen, D.E.3    Carey, M.C.4
  • 24
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000;102:731–744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 25
    • 18444377348 scopus 로고    scopus 로고
    • Redundant pathways for negative feedback regulation of bile acid production
    • Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, et al. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell 2002;2:721–731.
    • (2002) Dev Cell , vol.2 , pp. 721-731
    • Wang, L.1    Lee, Y.K.2    Bundman, D.3    Han, Y.4    Thevananther, S.5    Kim, C.S.6
  • 27
    • 0034743930 scopus 로고    scopus 로고
    • Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo
    • Pandak WM, Bohdan P, Franklund C, Mallonee DH, Eggertsen G, Bjorkhem I, et al. Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo. Gastroenterology 2001;120:1801–1809.
    • (2001) Gastroenterology , vol.120 , pp. 1801-1809
    • Pandak, W.M.1    Bohdan, P.2    Franklund, C.3    Mallonee, D.H.4    Eggertsen, G.5    Bjorkhem, I.6
  • 28
    • 0142060202 scopus 로고    scopus 로고
    • SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes
    • Zhang Y, Yin L, Hillgartner FB. SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes. J Lipid Res 2003;44:356–368.
    • (2003) J Lipid Res , vol.44 , pp. 356-368
    • Zhang, Y.1    Yin, L.2    Hillgartner, F.B.3
  • 29
    • 84899493129 scopus 로고    scopus 로고
    • Hepatic carboxylesterase 1 is essential for both normal and farnesoid X-receptor-controlled lipid homeostasis
    • Xu J, Li Y, Chen W, Xu Y, Yin L, Ge X, et al. Hepatic carboxylesterase 1 is essential for both normal and farnesoid X-receptor-controlled lipid homeostasis. Hepatology 2014;59:1761–1771.
    • (2014) Hepatology , vol.59 , pp. 1761-1771
    • Xu, J.1    Li, Y.2    Chen, W.3    Xu, Y.4    Yin, L.5    Ge, X.6
  • 30
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911–917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 31
    • 84935009342 scopus 로고    scopus 로고
    • A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism
    • Xu Y, Zalzala M, Xu J, Li Y, Yin L, Zhang Y. A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism. Nat Commun 2015;6:7466.
    • (2015) Nat Commun , vol.6 , pp. 7466
    • Xu, Y.1    Zalzala, M.2    Xu, J.3    Li, Y.4    Yin, L.5    Zhang, Y.6
  • 32
    • 84920401295 scopus 로고    scopus 로고
    • Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
    • Jiang C, Xie C, Li F, Zhang L, Nichols RG, Krausz KW, Cai J, et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest 2015;125:386–402.
    • (2015) J Clin Invest , vol.125 , pp. 386-402
    • Jiang, C.1    Xie, C.2    Li, F.3    Zhang, L.4    Nichols, R.G.5    Krausz, K.W.6    Cai, J.7
  • 33
    • 33644865172 scopus 로고    scopus 로고
    • Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo
    • Naik SU, Wang X, Da Silva JS, Jaye M, Macphee CH, Reilly MP, et al. Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation 2006;113:90–97.
    • (2006) Circulation , vol.113 , pp. 90-97
    • Naik, S.U.1    Wang, X.2    Da Silva, J.S.3    Jaye, M.4    Macphee, C.H.5    Reilly, M.P.6
  • 34
    • 0028157731 scopus 로고
    • Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster
    • Turley SD, Herndon MW, Dietschy JM. Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster. J Lipid Res 1994;35:328–339.
    • (1994) J Lipid Res , vol.35 , pp. 328-339
    • Turley, S.D.1    Herndon, M.W.2    Dietschy, J.M.3
  • 35
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005;2:217–225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5    McDonald, J.G.6
  • 36
    • 84865540426 scopus 로고    scopus 로고
    • Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
    • Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, Guo GL. Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology 2012;56:1034–1043.
    • (2012) Hepatology , vol.56 , pp. 1034-1043
    • Kong, B.1    Wang, L.2    Chiang, J.Y.3    Zhang, Y.4    Klaassen, C.D.5    Guo, G.L.6
  • 37
    • 0036086509 scopus 로고    scopus 로고
    • Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
    • Kerr TA, Saeki S, Schneider M, Schaefer K, Berdy S, Redder T, et al. Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell 2002;2:713–720.
    • (2002) Dev Cell , vol.2 , pp. 713-720
    • Kerr, T.A.1    Saeki, S.2    Schneider, M.3    Schaefer, K.4    Berdy, S.5    Redder, T.6
  • 38
    • 80051552124 scopus 로고    scopus 로고
    • Reverse cholesterol transport revisited: contribution of biliary versus intestinal cholesterol excretion
    • Brufau G, Groen AK, Kuipers F. Reverse cholesterol transport revisited: contribution of biliary versus intestinal cholesterol excretion. Arterioscler Thromb Vasc Biol 2011;31:1726–1733.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1726-1733
    • Brufau, G.1    Groen, A.K.2    Kuipers, F.3
  • 40
    • 84874723362 scopus 로고    scopus 로고
    • Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters
    • Jove M, Ayala V, Ramirez-Nunez O, Serrano JC, Cassanye A, Arola L, et al. Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters. Cardiovasc Res 2013;97:642–652.
    • (2013) Cardiovasc Res , vol.97 , pp. 642-652
    • Jove, M.1    Ayala, V.2    Ramirez-Nunez, O.3    Serrano, J.C.4    Cassanye, A.5    Arola, L.6
  • 41
    • 0034762627 scopus 로고    scopus 로고
    • Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding
    • Schwarz M, Russell DW, Dietschy JM, Turley SD. Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding. J Lipid Res 2001;42:1594–1603.
    • (2001) J Lipid Res , vol.42 , pp. 1594-1603
    • Schwarz, M.1    Russell, D.W.2    Dietschy, J.M.3    Turley, S.D.4
  • 42
    • 10744223501 scopus 로고    scopus 로고
    • Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice
    • Erickson SK, Lear SR, Deane S, Dubrac S, Huling SL, Nguyen L, et al. Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice. J Lipid Res 2003;44:1001–1009.
    • (2003) J Lipid Res , vol.44 , pp. 1001-1009
    • Erickson, S.K.1    Lear, S.R.2    Deane, S.3    Dubrac, S.4    Huling, S.L.5    Nguyen, L.6
  • 43
  • 44
    • 78149353724 scopus 로고    scopus 로고
    • Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice
    • Slatis K, Gafvels M, Kannisto K, Ovchinnikova O, Paulsson-Berne G, Parini P, et al. Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice. J Lipid Res 2010;51:3289–3298.
    • (2010) J Lipid Res , vol.51 , pp. 3289-3298
    • Slatis, K.1    Gafvels, M.2    Kannisto, K.3    Ovchinnikova, O.4    Paulsson-Berne, G.5    Parini, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.