Protein-protein interactions, not substrate recognition, dominate the turnover of chimeric assembly line polyketide synthases

Journal of Biological Chemistry

Volumn 291, Issue 31, 2016, Pages 16404-16415

  Klaus, Maja ^a   Ostrowski, Matthew P ^a   Austerjost, Jonas ^a   Robbins, Thomas ^a   Lowry, Brian ^a   Cane, David E ^b   Khosla, Chaitan ^a  

^a STANFORD UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; KETONES; PLANTS (BOTANY);

ACYL CARRIER PROTEINS; ENZYME SUBSTRATES; POLYKETIDE SYNTHASES; PROCESSING RATES; PROTEIN-PROTEIN INTERACTIONS; RELATIVE CONTRIBUTION; SPECIFIC ACTIVITY; SUBSTRATE RECOGNITION;

PROTEINS;

ACYL CARRIER PROTEIN; ERYTHROMYCIN SYNTHASE; POLYKETIDE SYNTHASE; RAPAMYCIN SYNTHASE; RIFAMYCIN SYNTHASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; HYBRID PROTEIN;

ARTICLE; CHIMERA; CONTROLLED STUDY; ENANTIOMER; ENZYME ACTIVITY; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; STEREOCHEMISTRY; CHEMISTRY; GENETICS; METABOLISM;

BACTERIAL PROTEINS; POLYKETIDE SYNTHASES; PROTEIN DOMAINS; RECOMBINANT FUSION PROTEINS;

EID: 84979745053     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.730531     Document Type: Article

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