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Volumn 7, Issue 1, 2016, Pages 473-489

HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3

Author keywords

EGFR family; HBx; Hepatocellular carcinoma; Lapatinib; Target therapy

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; ERLOTINIB; GEFITINIB; HEPATITIS B VIRUS X PROTEIN; LAPATINIB; ERBB2 PROTEIN, HUMAN; ERBB3 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; TRANSACTIVATOR PROTEIN;

EID: 84979672966     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/ONCOTARGET.6337     Document Type: Article
Times cited : (22)

References (69)
  • 3
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi PA, DePinho RA Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006; 6: 674-687
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 4
    • 79957485296 scopus 로고    scopus 로고
    • Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome
    • Herceg Z, Paliwal A Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome. Mutat Res 2011; 727: 55-61
    • (2011) Mutat Res , vol.727 , pp. 55-61
    • Herceg, Z.1    Paliwal, A.2
  • 5
    • 84862742319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1
    • Xu J, Liu H, Chen L, Wang S, Zhou L, Yun X, Sun L, Wen Y, Gu J Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1. Gastroenterology 2012; 143: 199-212 e194
    • (2012) Gastroenterology , vol.143 , pp. 199-212
    • Xu, J.1    Liu, H.2    Chen, L.3    Wang, S.4    Zhou, L.5    Yun, X.6    Sun, L.7    Wen, Y.8    Gu, J.9
  • 7
    • 77955655051 scopus 로고    scopus 로고
    • Hepatitis B virus X protein prevents apoptosis of hepatocellular carcinoma cells by upregulating SATB1 and HURP expression
    • Kuo TC, Chao CC Hepatitis B virus X protein prevents apoptosis of hepatocellular carcinoma cells by upregulating SATB1 and HURP expression. Biochem Pharmacol 2010; 80: 1093-1102
    • (2010) Biochem Pharmacol , vol.80 , pp. 1093-1102
    • Kuo, T.C.1    Chao, C.C.2
  • 8
    • 80052833369 scopus 로고    scopus 로고
    • Involvement of the NF-kappaB pathway in multidrug resistance induced by HBx in a hepatoma cell line
    • Liu Y, Lou G, Wu W, Zheng M, Shi Y, Zhao D, Chen Z Involvement of the NF-kappaB pathway in multidrug resistance induced by HBx in a hepatoma cell line. J Viral Hepat 2011; 18: e439-446
    • (2011) J Viral Hepat , vol.18 , pp. e439-446
    • Liu, Y.1    Lou, G.2    Wu, W.3    Zheng, M.4    Shi, Y.5    Zhao, D.6    Chen, Z.7
  • 9
    • 0034954277 scopus 로고    scopus 로고
    • X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis
    • Diao J, Garces R, Richardson CD X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis. Cytokine Growth Factor Rev 2001; 12: 189-205
    • (2001) Cytokine Growth Factor Rev , vol.12 , pp. 189-205
    • Diao, J.1    Garces, R.2    Richardson, C.D.3
  • 11
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, Xu J, Sun Y, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009; 10: 25-34
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3    Tsao, C.J.4    Qin, S.5    Kim, J.S.6    Luo, R.7    Feng, J.8    Ye, S.9    Yang, T.S.10    Xu, J.11    Sun, Y.12
  • 15
    • 78650835158 scopus 로고    scopus 로고
    • Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives
    • Shen YC, Hsu C, Cheng AL Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives. J Gastroenterol 2010; 45: 794-807
    • (2010) J Gastroenterol , vol.45 , pp. 794-807
    • Shen, Y.C.1    Hsu, C.2    Cheng, A.L.3
  • 16
    • 0036254553 scopus 로고    scopus 로고
    • Requisite role of VEGF receptors in angiogenesis of hepatocellular carcinoma: a comparison with angiopoietin/Tie pathway
    • Dhar DK, Naora H, Yamanoi A, Ono T, Kohno H, Otani H, Nagasue N Requisite role of VEGF receptors in angiogenesis of hepatocellular carcinoma: a comparison with angiopoietin/Tie pathway. Anticancer Res 2002; 22: 379-386
    • (2002) Anticancer Res , vol.22 , pp. 379-386
    • Dhar, D.K.1    Naora, H.2    Yamanoi, A.3    Ono, T.4    Kohno, H.5    Otani, H.6    Nagasue, N.7
  • 19
    • 84856051012 scopus 로고    scopus 로고
    • Sorafenib: complexities of Rafdependent and Raf-independent signaling are now unveiled
    • Matsuda Y, Fukumoto M Sorafenib: complexities of Rafdependent and Raf-independent signaling are now unveiled. Med Mol Morphol 2011; 44: 183-189
    • (2011) Med Mol Morphol , vol.44 , pp. 183-189
    • Matsuda, Y.1    Fukumoto, M.2
  • 20
    • 77956824960 scopus 로고    scopus 로고
    • Sorafenib for the treatment of unresectable hepatocellular carcinoma
    • Furuse J Sorafenib for the treatment of unresectable hepatocellular carcinoma. Biologics 2008; 2: 779-788
    • (2008) Biologics , vol.2 , pp. 779-788
    • Furuse, J.1
  • 22
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag HB Hepatocellular carcinoma. N Engl J Med 2011; 365: 1118-1127
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 23
    • 84984541581 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells
    • Chen KF, Chen HL, Tai WT, Feng WC, Hsu CH, Chen PJ, Cheng AL Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells. J Pharmacol Exp Ther 2011; 337: 155-161
    • (2011) J Pharmacol Exp Ther , vol.337 , pp. 155-161
    • Chen, K.F.1    Chen, H.L.2    Tai, W.T.3    Feng, W.C.4    Hsu, C.H.5    Chen, P.J.6    Cheng, A.L.7
  • 24
    • 84884327551 scopus 로고    scopus 로고
    • Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma
    • Zhai B, Sun XY Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma. World J Hepatol 2013; 5: 345-352
    • (2013) World J Hepatol , vol.5 , pp. 345-352
    • Zhai, B.1    Sun, X.Y.2
  • 27
    • 84876743991 scopus 로고    scopus 로고
    • Hypoxiamediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1alpha inhibition in hepatocellular carcinoma
    • Liang Y, Zheng T, Song R, Wang J, Yin D, Wang L, Liu H, Tian L, Fang X, Meng X, Jiang H, Liu J, et al. Hypoxiamediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1alpha inhibition in hepatocellular carcinoma. Hepatology 2013; 57: 1847-1857
    • (2013) Hepatology , vol.57 , pp. 1847-1857
    • Liang, Y.1    Zheng, T.2    Song, R.3    Wang, J.4    Yin, D.5    Wang, L.6    Liu, H.7    Tian, L.8    Fang, X.9    Meng, X.10    Jiang, H.11    Liu, J.12
  • 29
    • 84871721735 scopus 로고    scopus 로고
    • Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth
    • van Malenstein H, Dekervel J, Verslype C, Van Cutsem E, Windmolders P, Nevens F, van Pelt J Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth. Cancer Lett 2013; 329: 74-83
    • (2013) Cancer Lett , vol.329 , pp. 74-83
    • van Malenstein, H.1    Dekervel, J.2    Verslype, C.3    Van Cutsem, E.4    Windmolders, P.5    Nevens, F.6    van Pelt, J.7
  • 31
    • 4143076078 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor
    • El-Rayes BF, LoRusso PM Targeting the epidermal growth factor receptor. Br J Cancer 2004; 91: 418-424
    • (2004) Br J Cancer , vol.91 , pp. 418-424
    • El-Rayes, B.F.1    LoRusso, P.M.2
  • 33
    • 27544497021 scopus 로고    scopus 로고
    • EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer
    • Huether A, Hopfner M, Baradari V, Schuppan D, Scherubl H EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. Biochem Pharmacol 2005; 70: 1568-1578
    • (2005) Biochem Pharmacol , vol.70 , pp. 1568-1578
    • Huether, A.1    Hopfner, M.2    Baradari, V.3    Schuppan, D.4    Scherubl, H.5
  • 34
    • 77349125581 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy
    • Gazdar AF Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer Metastasis Rev 2010; 29: 37-48
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 37-48
    • Gazdar, A.F.1
  • 35
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006; 3: 269-280
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 36
    • 38849152398 scopus 로고    scopus 로고
    • Targeted therapies: a new generation of cancer treatments
    • Gerber DE Targeted therapies: a new generation of cancer treatments. Am Fam Physician 2008; 77: 311-319
    • (2008) Am Fam Physician , vol.77 , pp. 311-319
    • Gerber, D.E.1
  • 37
    • 42049110755 scopus 로고    scopus 로고
    • Targeted therapies for hepatocellular carcinoma
    • Skelton MR, O'Neil B Targeted therapies for hepatocellular carcinoma. Clin Adv Hematol Oncol 2008; 6: 209-218
    • (2008) Clin Adv Hematol Oncol , vol.6 , pp. 209-218
    • Skelton, M.R.1    O'Neil, B.2
  • 38
    • 79955433548 scopus 로고    scopus 로고
    • Targeted therapies for hepatocellular carcinoma
    • Villanueva A, Llovet JM Targeted therapies for hepatocellular carcinoma. Gastroenterology 2011; 140: 1410-1426
    • (2011) Gastroenterology , vol.140 , pp. 1410-1426
    • Villanueva, A.1    Llovet, J.M.2
  • 39
    • 70349546374 scopus 로고    scopus 로고
    • Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis
    • Matsuda Y, Ichida T Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis. Med Mol Morphol 2009; 42: 138-142
    • (2009) Med Mol Morphol , vol.42 , pp. 138-142
    • Matsuda, Y.1    Ichida, T.2
  • 40
    • 84864587705 scopus 로고    scopus 로고
    • Hepatitis B virus X protein upregulates mTOR signaling through IKKbeta to increase cell proliferation and VEGF production in hepatocellular carcinoma
    • Yen CJ, Lin YJ, Yen CS, Tsai HW, Tsai TF, Chang KY, Huang WC, Lin PW, Chiang CW, Chang TT Hepatitis B virus X protein upregulates mTOR signaling through IKKbeta to increase cell proliferation and VEGF production in hepatocellular carcinoma. PLoS One 2012; 7: e41931
    • (2012) PLoS One , vol.7
    • Yen, C.J.1    Lin, Y.J.2    Yen, C.S.3    Tsai, H.W.4    Tsai, T.F.5    Chang, K.Y.6    Huang, W.C.7    Lin, P.W.8    Chiang, C.W.9    Chang, T.T.10
  • 43
    • 34249901562 scopus 로고    scopus 로고
    • RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma
    • Cheng AS, Wong N, Tse AM, Chan KY, Chan KK, Sung JJ, Chan HL RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma. Cancer Lett 2007; 253: 43-52
    • (2007) Cancer Lett , vol.253 , pp. 43-52
    • Cheng, A.S.1    Wong, N.2    Tse, A.M.3    Chan, K.Y.4    Chan, K.K.5    Sung, J.J.6    Chan, H.L.7
  • 44
    • 0034682769 scopus 로고    scopus 로고
    • Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
    • Shih WL, Kuo ML, Chuang SE, Cheng AL, Doong SL Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. J Biol Chem 2000; 275: 25858-25864
    • (2000) J Biol Chem , vol.275 , pp. 25858-25864
    • Shih, W.L.1    Kuo, M.L.2    Chuang, S.E.3    Cheng, A.L.4    Doong, S.L.5
  • 45
    • 0035834663 scopus 로고    scopus 로고
    • Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor
    • Hellyer NJ, Kim MS, Koland JG Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor. J Biol Chem 2001; 276: 42153-42161
    • (2001) J Biol Chem , vol.276 , pp. 42153-42161
    • Hellyer, N.J.1    Kim, M.S.2    Koland, J.G.3
  • 46
    • 84862242780 scopus 로고    scopus 로고
    • Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines
    • O'Neill F, Madden SF, Aherne ST, Clynes M, Crown J, Doolan P, O'Connor R Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines. Mol Cancer 2012; 11: 41
    • (2012) Mol Cancer , vol.11 , pp. 41
    • O'Neill, F.1    Madden, S.F.2    Aherne, S.T.3    Clynes, M.4    Crown, J.5    Doolan, P.6    O'Connor, R.7
  • 48
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
    • Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, Ratzkin BJ, Yarden Y A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 1996; 16: 5276-5287
    • (1996) Mol Cell Biol , vol.16 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3    Levkowitz, G.4    Karunagaran, D.5    Lavi, S.6    Ratzkin, B.J.7    Yarden, Y.8
  • 49
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: the biology of ErbB-2 and ErbB-3
    • Citri A, Skaria KB, Yarden Y The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 2003; 284: 54-65
    • (2003) Exp Cell Res , vol.284 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 50
    • 77957784428 scopus 로고    scopus 로고
    • ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
    • Krig SR, Miller JK, Frietze S, Beckett LA, Neve RM, Farnham PJ, Yaswen PI, Sweeney CA ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells. Oncogene 2010; 29: 5500-5510
    • (2010) Oncogene , vol.29 , pp. 5500-5510
    • Krig, S.R.1    Miller, J.K.2    Frietze, S.3    Beckett, L.A.4    Neve, R.M.5    Farnham, P.J.6    Yaswen, P.I.7    Sweeney, C.A.8
  • 51
    • 80052167511 scopus 로고    scopus 로고
    • Liver cell transformation in chronic HBV infection
    • Benhenda S, Cougot D, Neuveut C, Buendia MA Liver cell transformation in chronic HBV infection. Viruses 2009; 1: 630-646
    • (2009) Viruses , vol.1 , pp. 630-646
    • Benhenda, S.1    Cougot, D.2    Neuveut, C.3    Buendia, M.A.4
  • 52
    • 0029982621 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins
    • Su F, Schneider RJ Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins. J Virol 1996; 70: 4558-4566
    • (1996) J Virol , vol.70 , pp. 4558-4566
    • Su, F.1    Schneider, R.J.2
  • 53
    • 0029895723 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases
    • Benn J, Su F, Doria M, Schneider RJ Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. J Virol 1996; 70: 4978-4985
    • (1996) J Virol , vol.70 , pp. 4978-4985
    • Benn, J.1    Su, F.2    Doria, M.3    Schneider, R.J.4
  • 54
    • 84904095383 scopus 로고    scopus 로고
    • Hepatocystin contributes to interferon-mediated antiviral response to hepatitis B virus by regulating hepatocyte nuclear factor 4alpha
    • Shin GC, Ahn SH, Choi HS, Kim J, Park ES, Kim DH, Kim KH Hepatocystin contributes to interferon-mediated antiviral response to hepatitis B virus by regulating hepatocyte nuclear factor 4alpha. Biochim Biophys Acta 2014; 1842: 1648-1657
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 1648-1657
    • Shin, G.C.1    Ahn, S.H.2    Choi, H.S.3    Kim, J.4    Park, E.S.5    Kim, D.H.6    Kim, K.H.7
  • 55
    • 84896317803 scopus 로고    scopus 로고
    • Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells
    • You X, Liu F, Zhang T, Lv N, Liu Q, Shan C, Du Y, Kong G, Wang T, Ye L, Zhang X Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells. Oncogene 2014; 33: 449-460
    • (2014) Oncogene , vol.33 , pp. 449-460
    • You, X.1    Liu, F.2    Zhang, T.3    Lv, N.4    Liu, Q.5    Shan, C.6    Du, Y.7    Kong, G.8    Wang, T.9    Ye, L.10    Zhang, X.11
  • 56
    • 84874607911 scopus 로고    scopus 로고
    • HBx-induced NF-kappaB signaling in liver cells is potentially mediated by the ternary complex of HBx with p22-FLIP and NEMO
    • Lim KH, Choi HS, Park YK, Park ES, Shin GC, Kim DH, Ahn SH, Kim KH HBx-induced NF-kappaB signaling in liver cells is potentially mediated by the ternary complex of HBx with p22-FLIP and NEMO. PLoS One 2013; 8: e57331
    • (2013) PLoS One , vol.8
    • Lim, K.H.1    Choi, H.S.2    Park, Y.K.3    Park, E.S.4    Shin, G.C.5    Kim, D.H.6    Ahn, S.H.7    Kim, K.H.8
  • 57
    • 84922336092 scopus 로고    scopus 로고
    • HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress
    • Cho HK, Kim SY, Kyaw YY, Win AA, Koo SH, Kim HH, Cheong J HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress. Biochem J 2015; 466: 115-121
    • (2015) Biochem J , vol.466 , pp. 115-121
    • Cho, H.K.1    Kim, S.Y.2    Kyaw, Y.Y.3    Win, A.A.4    Koo, S.H.5    Kim, H.H.6    Cheong, J.7
  • 58
    • 79954549230 scopus 로고    scopus 로고
    • Hepatitis B virus X protein regulates the mEZH2 promoter via the E2F1-binding site in AML12 cells
    • Shi XY, Zhang YY, Zhou XW, Lu JS, Guo ZK, Huang PT Hepatitis B virus X protein regulates the mEZH2 promoter via the E2F1-binding site in AML12 cells. Chin J Cancer 2011; 30: 273-279
    • (2011) Chin J Cancer , vol.30 , pp. 273-279
    • Shi, X.Y.1    Zhang, Y.Y.2    Zhou, X.W.3    Lu, J.S.4    Guo, Z.K.5    Huang, P.T.6
  • 59
    • 77957252647 scopus 로고    scopus 로고
    • The IKK complex, a central regulator of NF-kappaB activation
    • Israel A The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol 2010; 2: a000158
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Israel, A.1
  • 60
    • 84862933773 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces IKKalpha nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells
    • Huang WC, Chen WS, Chen YJ, Wang LY, Hsu SC, Chen CC, Hung MC Hepatitis B virus X protein induces IKKalpha nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells. J Cell Physiol 2012; 227: 1446-1454
    • (2012) J Cell Physiol , vol.227 , pp. 1446-1454
    • Huang, W.C.1    Chen, W.S.2    Chen, Y.J.3    Wang, L.Y.4    Hsu, S.C.5    Chen, C.C.6    Hung, M.C.7
  • 61
    • 77951490498 scopus 로고    scopus 로고
    • Novel inhibitors in development for hepatocellular carcinoma
    • Worns MA, Galle PR Novel inhibitors in development for hepatocellular carcinoma. Expert Opin Investig Drugs 2010; 19: 615-629
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 615-629
    • Worns, M.A.1    Galle, P.R.2
  • 62
    • 77951465662 scopus 로고    scopus 로고
    • Beyond sorafenib: novel targeted therapies for advanced hepatocellular carcinoma
    • Zhu AX Beyond sorafenib: novel targeted therapies for advanced hepatocellular carcinoma. Expert Opin Investig Drugs 2010; 19: 663-672
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 663-672
    • Zhu, A.X.1
  • 64
    • 84863067986 scopus 로고    scopus 로고
    • Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways
    • Kim H, Lim HY Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. J Korean Med Sci 2011; 26: 1563-1568
    • (2011) J Korean Med Sci , vol.26 , pp. 1563-1568
    • Kim, H.1    Lim, H.Y.2
  • 65
    • 1942533428 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression
    • Ahn SY, Cho CH, Park KG, Lee HJ, Lee S, Park SK, Lee IK, Koh GY Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression. Am J Pathol 2004; 164: 1663-1672
    • (2004) Am J Pathol , vol.164 , pp. 1663-1672
    • Ahn, S.Y.1    Cho, C.H.2    Park, K.G.3    Lee, H.J.4    Lee, S.5    Park, S.K.6    Lee, I.K.7    Koh, G.Y.8
  • 66
    • 0026355418 scopus 로고
    • Temporal aspects of major viral transcript expression in Hep G2 cells transfected with cloned hepatitis B virus DNA: with emphasis on the X transcript
    • Wu HL, Chen PJ, Lin MH, Chen DS Temporal aspects of major viral transcript expression in Hep G2 cells transfected with cloned hepatitis B virus DNA: with emphasis on the X transcript. Virology 1991; 185: 644-651
    • (1991) Virology , vol.185 , pp. 644-651
    • Wu, H.L.1    Chen, P.J.2    Lin, M.H.3    Chen, D.S.4
  • 67
    • 84872147693 scopus 로고    scopus 로고
    • C-terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by C-Jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma
    • Sze KM, Chu GK, Lee JM, Ng IO C-terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by C-Jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma. Hepatology 2013; 57: 131-139
    • (2013) Hepatology , vol.57 , pp. 131-139
    • Sze, K.M.1    Chu, G.K.2    Lee, J.M.3    Ng, I.O.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.