Overexpression of VEGF is associated with positive p53 immunostaining in hepatocellular carcinoma (HCC) and adverse outcome of HCC patients

Journal of Surgical Oncology

Volumn 98, Issue 5, 2008, Pages 349-357

  Tseng, Po Lin ^a   Tai, Ming Hong ^b   Huang, Chao Cheng ^a   Wang, Chih Chi ^a   Lin, Jui Wei ^a   Hung, Chao Hung ^a   Chen, Chien Hung ^a   Wang, Jing Houng ^a   Lu, Sheng Nan ^a   Lee, Chuan Mo ^a   Changchien, Chi Sin ^a   Hu, Tsung Hui ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Hepatocellular carcinoma; Microvessel density; P53; Prognosis; Vascular endothelial growth factor; Viremia

Indexed keywords

ALPHA FETOPROTEIN; VASCULOTROPIN;

ADULT; ADVANCED CANCER; ADVERSE OUTCOME; AGE DISTRIBUTION; AGED; ANGIOGENESIS; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; MICROVESSEL DENSITY; OUTCOME ASSESSMENT; PARAMETER; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SEX DIFFERENCE; TUMOR SUPPRESSOR GENE; VIREMIA;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; FEMALE; GENE EXPRESSION; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; SEX FACTORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 53549085161     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21109     Document Type: Article

References (40)

1. Ziche M, Gullino PM: Angiogenesis and neoplastic progression in vitro. J Natl Cancer Inst 1982;69:483-487.
2. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990;82:4-6.
3. Zetter BR: Angiogenesis and tumor metastasis. Annu Rev Med 1998;49:407-424.
4. Leung DW, Cachianes G, Kuang WJ, et al.: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-1309.
5. Dvorak HF, Brown LF, Detmar M, et al.: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995;146:1029-1039.
6. Li XM, Tang ZY, Zhou G, et al.: Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma. J Exp Clin Cancer Res 1998;17:13-17.
7. El-Assal ON, Yamanoi A, Soda Y, et al.: Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: Possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology 1998;27:1554-1562.
8. An FQ, Matsuda M, Fujii H, et al.: Expression of vascular endothelial growth factor in surgical specimens of hepatocellular carcinoma. J Cancer Res Clin Oncol 2000;126:153-160.
9. Jeng KS, Sheen IS, Wang YC, et al.: Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: A prospective study. World J Gastroenterol 2004;10:643-648.
10. Sun HC, Tang ZY, Li XM, et al.: Microvessel density of hepatocellular carcinoma: Its relationship with prognosis. J Cancer Res Clin Oncol 1999;125:419-426.
11. Yao DF, Wu XH, Zhu Y, et al.: Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopafhologic features in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2005;4:220-226.
12. Miura H, Miyazaki T, Kuroda M, et al.: Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma. J Hepatol 1997;27:854-861.
13. Mise M, Arii S, Higashituji H, et al.: Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology 1996;23:455-464.
14. Yamaguchi R, Yano H, Iemura A, et al.: Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 1998;28:68-77.
15. Staib F, Hussain SP, Hofseth LJ, et al.: TP53 and liver carcinogenesis. Hum Mutat 2003;21:201-216.
16. Buendia MA: Genetics of hepatocellular carcinoma. Semin Cancer Biol 2000;10:185-200.
17. Ng IO, Lai EC, Chan AS, et al.: Overexpression of p53 in hepatocellular carcinomas: A clinicopathological and prognostic correlation. J Gastroenterol Hepatol 1995;10:250-255.
18. Jeng KS, Sheen IS, Chen BF, et al.: Is the p53 gene mutation of prognostic value in hepatocellular carcinoma after resection? Arch Surg 2000;135:1329-1333.
19. Nishida N, Fukuda Y, Kokuryu H, et al.: Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma. Cancer Res 1993;53:368-372.
20. Gullino PM, Ziehe M, Alessandri G: Gangliosides, copper ions and angiogenic capacity of adult tissues. Cancer Metastasis Rev 1990;9:239-251.
21. Weidner N, Carroll PR, Flax J, et al.: Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 1993;143:401-409.
22. Hollingsworth HC, Kohn EC, Steinberg SM, et al.: Tumor angiogenesis in advanced stage ovarian carcinoma. Am J Pathol 1995;147:33-41.
23. Araya M, Terashima M, Takagane A, et al.: Microvessel count predicts metastasis and prognosis in patients with gastric cancer. J Surg Oncol 1997;65:232-236.
24. Tanigawa N, Amaya H, Matsumura M, et al.: Tumor angiogenesis and mode of metastasis in patients with colorectal cancer. Cancer Res 1997;57:1043-1046.
25. Deli G, Jin CH, Mu R, et al.: Immunohistochemical assessment of angiogenesis in hepatocellular carcinoma and surrounding cirrhotic liver tissues. World J Gastroenterol 2005;11:960-963.
26. Shimoda K, Mori M, Shibuta K, et al.: Vascular endothelial growth factor/vascular permeability factor mRNA expression in patients with chronic hepatitis C and hepatocellular carcinoma. Int J Oncol 1999;14:353-359.
27. Ohkubo K, Kato Y, Ichikawa T, et al.: Viral load is a significant prognostic factor for hepatitis B virus-associated hepatocellular carcinoma. Cancer 2002;94:2663-2668.
28. Helaly GF, Abou Shamaa LA: Influence of hepatitis C virus infection on circulating levels of sICAM-1 and VEGF in patients with hepatitis C and hepatocellular carcinoma (HCC) and their role in enhancing detection of HCC. Egypt J Immunol 2006;13:27-38.
29. Kastan MB, Onyekwere O, Sidransky D, et al.: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991;51:6304-6311.
30. Lane DP: Cancer. p53, guardian of the genome. Nature 1992;358:15-16.
31. Farmer G, Bargonetti J, Zhu H, et al.: Wild-type p53 activates transcription in vitro. Nature 1992;358:83-86.
32. Yin Y, Tainsky MA, Bischoff FZ, et al.: Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992;70:937-948.
33. Hu TH, Huang CC, Lin PR, et al.: Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma. Cancer 2003;97:1929-1940.
34. Dameron KM, Volpert OV, Tainsky MA, et al.: Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 1994;265:1582-1584.
35. Mukhopadhyay D, Tsiokas L, Sukhatme VP: Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res 1995;55:6161-6165.
36. Kieser A, Weich HA, Brandner G, et al.: Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 1994;9:963-969.
37. Kang SM, Maeda K, Onoda N, et al.: Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis. Int J Cancer 1997;74:502-507.
38. Strohmeyer D, Rossing C, Bauerfeind A, et al.: Vascular endothelial growth factor and its correlation with angiogenesis and p53 expression in prostate cancer. Prostate 2000;45:216-224.
39. Koide N, Nishio A, Hiraguri M, et al.: Coexpression of vascular endothelial growth factor and p53 protein in squamous cell carcinoma of the esophagus. Am J Gastroenterol 2001;96:1733-1740.
40. Linderholm BK, Lindahl T, Holmberg L, et al.: The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer. Cancer Res 2001;61:2256-2260.