Combination of angiotensin ii and L-Ng-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 310, Issue 6, 2016, Pages H667-H680

  Hamilton, Dale J ^a   Zhang, Aijun ^a   Li, Shumin ^a   Cao, Tram N ^a   Smith, Jessie A ^a   Vedula, Indira ^a   Cordero Reyes, Andrea M ^a   Youker, Keith A ^a   Torre Amione, Guillermo ^a,b   Gupte, Anisha A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

Author keywords

Angiotensin II; Heart failure; Mitochondria; Nitric oxide; Oxidative stress

Indexed keywords

ADENOSINE DIPHOSPHATE; ANGIOTENSIN II; ATP2A2 PROTEIN; CAMK2B PROTEIN; CARBONYL DERIVATIVE; HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; N(G) NITROARGININE METHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITRIC OXIDE; NPPA PROTEIN; NPPB PROTEIN; OLIGOMYCIN; PROTEIN; PYRUVATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; ATP2A2 PROTEIN, MOUSE; BRAIN NATRIURETIC PEPTIDE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CAMK2B PROTEIN, MOUSE; ENZYME INHIBITOR; NATRIURETIC PEPTIDE TYPE C; NPPA PROTEIN, MOUSE; PROTEIN PRECURSOR; PYRUVATE DEHYDROGENASE COMPLEX; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELEVATED BLOOD PRESSURE; FATTY ACID METABOLISM; GENE EXPRESSION; GENERAL CONDITION DETERIORATION; HEART CONTRACTION; HEART EDEMA; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; MICROARRAY ANALYSIS; MOUSE; MUSCLE FIBRIL; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATION CONTROL; RESPIRATORY FUNCTION; ANIMAL; CARDIAC MUSCLE; CARDIOMEGALY; DRUG EFFECTS; GENETICS; HEART; HEART MITOCHONDRION; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANGIOTENSIN II; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CARDIOMEGALY; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ENZYME INHIBITORS; GENE EXPRESSION; HEART; HEART FAILURE; HYDROGEN PEROXIDE; MICE; MITOCHONDRIA, HEART; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; NATRIURETIC PEPTIDE, C-TYPE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXIDATIVE STRESS; PROTEIN PRECURSORS; PYRUVATE DEHYDROGENASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; VASOCONSTRICTOR AGENTS;

EID: 84979641476     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00746.2015     Document Type: Article

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