Antimalarial benzoxaboroles target Plasmodium falciparum leucyl-tRNA synthetase

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 8, 2016, Pages 4886-4895

  Sonoiki, Ebere ^a,b   Palencia, Andres ^c   Guo, Denghui ^a   Ahyong, Vida ^a   Dong, Chen ^d   Li, Xianfeng ^d   Hernandez, Vincent S ^d   Zhang, Yong Kang ^d   Choi, Wai ^d   Gut, Jiri ^a   Legac, Jennifer ^a   Cooper, Roland ^e   Alley, M R K ^d   Freund, Yvonne R ^d   DeRisi, Joseph ^a   Cusack, Stephen ^c   Rosenthal, Philip J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^d PFIZER INC   (United States)

^e DOMINICAN UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AN 6426; AN 8432; ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; LEUCINE; LEUCINE TRANSFER RNA LIGASE; NORVALINE; UNCLASSIFIED DRUG; AN6426; BORON DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; CLONE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTALLIZATION; DNA POLYMORPHISM; DRUG MECHANISM; DRUG POTENCY; GENE SEQUENCE; HUMAN; HUMAN CELL; IC50; MOUSE; NONHUMAN; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RODENT MALARIA; STRUCTURE ACTIVITY RELATION; WILD TYPE; DRUG EFFECTS; DRUG RESISTANCE; MALARIA, FALCIPARUM; METABOLISM; PARASITOLOGY;

ANTIMALARIALS; BORON COMPOUNDS; DRUG RESISTANCE; INHIBITORY CONCENTRATION 50; LEUCINE-TRNA LIGASE; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM;

EID: 84979623010     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00820-16     Document Type: Article

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