Disposition and metabolism of GSK2251052 in humans: A novel boron-containing antibiotics

Drug Metabolism and Disposition

Volumn 41, Issue 5, 2013, Pages 1070-1081

  Bowers, Gary D ^a   Tenero, David ^a   Patel, Parul ^b   Huynh, Phuong ^a   Sigafoos, James ^a   O'Mara, Kathryn ^a   Young, Graeme C ^c   Dumont, Etienne ^b   Cunningham, Elizabeth ^a   Kurtinecz, Milena ^b   Stump, Patrick ^a   Conde, J J ^d   Chism, John P ^a   Reese, Melinda J ^a   Yueh, Yun Lan ^a   Tomayko, John F ^b  

^a Department of Drug Metabolism and Pharmacokinetics ^*  (United States)

^b GLAXOSMITHKLINE   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d API Chemistry and Analysis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CARBOXYLIC ACID; DRUG METABOLITE; GSK 2251052; PROPANOL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL COMPONENT; CONTROLLED STUDY; DIARRHEA; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FATALITY; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG METABOLISM; DRUG OXIDATION; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG URINE LEVEL; FEMALE; HAPLORHINI; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; INSOMNIA; INTESTINAL DYSMOTILITY; LIQUID SCINTILLATION COUNTING; MALE; MASS SPECTROMETRY; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RADIOACTIVITY; SINGLE DRUG DOSE; TISSUE DISTRIBUTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BORON; BORON COMPOUNDS; HUMANS; MACACA FASCICULARIS; MALE; MASS SPECTROMETRY;

BACTERIA (MICROORGANISMS);

EID: 84876780110     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.050153     Document Type: Article

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