Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone + salt-induced cardiac fibrosis in vivo

Journal of Molecular and Cellular Cardiology

Volumn 98, Issue , 2016, Pages 95-102

  Mummidi, Srinivas ^a   Das, Nitin A ^a   Carpenter, Andrea J ^a   Kandikattu, Hemanthkumar ^b   Krenz, Maike ^b   Siebenlist, Ulrich ^c   Valente, Anthony J ^a   Chandrasekar, Bysani ^b,d  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b University of Missouri   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aldosterone; AMPK activators; Cardiac fibrosis; Metformin; TRAF3IP2

Indexed keywords

ALDOSTERONE; COLLAGEN; CYTOKINE; HYDROGEN PEROXIDE; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN PPM1A; PROTEIN TRAF3IP2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SODIUM CHLORIDE; SPIRONOLACTONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; AUTACOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PPM1A PROTEIN, MOUSE; PROTEIN PHOSPHATASE 2C; REACTIVE OXYGEN METABOLITE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRAF3IP2 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME INHIBITION; HEART FIBROBLAST; HEART MUSCLE FIBROSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SYSTOLIC BLOOD PRESSURE; WILD TYPE MOUSE; ANIMAL; CARDIAC MUSCLE; CARDIOMEGALY; CELL MOTION; DRUG EFFECTS; FIBROSIS; LIPID PEROXIDATION; METABOLISM; MYOFIBROBLAST; PATHOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALDOSTERONE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARDIOMEGALY; CELL MOVEMENT; CELL PROLIFERATION; COLLAGEN; CYTOKINES; FIBROSIS; HYDROGEN PEROXIDE; INFLAMMATION MEDIATORS; LIPID PEROXIDATION; MALE; METFORMIN; MICE; MYOCARDIUM; MYOFIBROBLASTS; PROTEIN PHOSPHATASE 2C; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84979609999     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2016.07.006     Document Type: Article

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